POMC, proopiomelanocortin, 5443

N. diseases: 873; N. variants: 39
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group CTD_human Arachidonic acid metabolism in glucocorticoid-induced hypertension. 18067589 2008
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group CTD_human Antioxidant vitamins and adrenocorticotrophic hormone-induced hypertension in rats. 17994356 2007
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group BEFREE The correlation between excretion of aldosterone and cortisol metabolites and suggests that, in TT subjects, ACTH exerts an important common regulatory influence on adrenal corticosteroid production in subjects with hypertension. 17651452 2007
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic group CTD_human The aim of the present study was to investigate the effects of aspirin, a potent antioxidant, on adrenocorticotropic hormone (ACTH) and dexamethasone (Dex)-induced hypertension. 17954371 2007
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group CTD_human The aim of the present study was to investigate the effects of aspirin, a potent antioxidant, on adrenocorticotropic hormone (ACTH) and dexamethasone (Dex)-induced hypertension. 17954371 2007
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic group CTD_human Antioxidant vitamins and adrenocorticotrophic hormone-induced hypertension in rats. 17994356 2007
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic group CTD_human The ACTH and Dex hypertension were partially reversed by folic acid. 17324744 2007
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group CTD_human The ACTH and Dex hypertension were partially reversed by folic acid. 17324744 2007
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic group CTD_human Thus, NAC partially prevented but did not reverse ACTH-induced hypertension. 16546835 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group CTD_human Thus, NAC partially prevented but did not reverse ACTH-induced hypertension. 16546835 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group CTD_human Atorvastatin prevented and partially reversed adrenocorticotropic hormone-induced hypertension in the rat. 16620303 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic group CTD_human Atorvastatin prevented and partially reversed adrenocorticotropic hormone-induced hypertension in the rat. 16620303 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic group CTD_human This result indicates that the cardiac glycoside binding site of the alpha1 isoform can also mediate ACTH-induced hypertension. 16243970 2005
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group CTD_human This result indicates that the cardiac glycoside binding site of the alpha1 isoform can also mediate ACTH-induced hypertension. 16243970 2005
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group CTD_human Apocynin (but not allopurinol) co-treatment prevented (142+/-3 ACTH, 120+/-4 mm Hg apocynin+ACTH, P'<0.001) and reversed ACTH-induced hypertension (133+/-4 to 118+/-5 mm Hg, P<.05). 16053986 2005
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic group CTD_human Apocynin (but not allopurinol) co-treatment prevented (142+/-3 ACTH, 120+/-4 mm Hg apocynin+ACTH, P'<0.001) and reversed ACTH-induced hypertension (133+/-4 to 118+/-5 mm Hg, P<.05). 16053986 2005
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic group CTD_human We hypothesized that ACTH-induced hypertension in the rat is characterized by increased EPO production. 15110907 2004
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic group CTD_human Nitric oxide donation lowers blood pressure in adrenocorticotrophic hormone-induced hypertensive rats. 15554453 2004
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group BEFREE PNAH was associated with cushingoid features, virilization and hypertension with a lack of cortisol suppression on high DST, undetectable plasma ACTH and absent cortisol and ACTH responses to CRH. 15521956 2004
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group CTD_human Nitric oxide donation lowers blood pressure in adrenocorticotrophic hormone-induced hypertensive rats. 15554453 2004
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group CTD_human Accordingly we hypothesized that ACTH-induced hypertension would be reversed by BH4 supplementation. 15132301 2004
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group CTD_human We hypothesized that ACTH-induced hypertension in the rat is characterized by increased EPO production. 15110907 2004
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic group CTD_human Accordingly we hypothesized that ACTH-induced hypertension would be reversed by BH4 supplementation. 15132301 2004
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic group CTD_human The anti-oxidant Tempol reverses and partially prevents adrenocorticotrophic hormone-induced hypertension in the rat. 12872045 2003
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic group CTD_human Lipopolysaccharide reverses adrenocorticotrophic hormone-induced hypertension in the rat. 12887135 2003