|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Elevated concentrations of M-HDL particles and elevated levels of HDL-associated PON1 may contribute to long-term protection from the vascular complications of diabetes by pathways that are independent of total cholesterol and HDL cholesterol.
|
31597668 |
2020 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Oxidation has been implicated in the onset of diabetes, and it can be hypothesized that PON1 may have a protective effect on diabetes.
|
18290860 |
2008 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
There was neither statistically significant association of PON1 polymorphisms with tumour stages nor with diabetes mellitus connected with PC.
|
23438848 |
2012 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
We quantified MDA levels and measured PON1 (paraoxonase/arylesterase) enzymatic activities in subjects suffering from cataract due to aging and diabetes.
|
19439227 |
2009 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
The increase percent of serum PON3 protein was higher than that of serum PON1 protein and the increase percent of serum lactonase activity was higher than that of serum paraoxonase and arylesterase activities in diabetes+lipoic acid group.We can report that, like PON1 protein, PON3 protein and actually its lactonase activity may also have a role as an antioxidant in diabetes mellitus and lipoic acid treatment may be useful for the prevention of the atherosclerotic complications of diabetes by increasing serum PON1 and PON3 protein levels and serum enzyme activities.
|
26849669 |
2019 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
We have compared the ability of HDL from people with type 2 diabetes (n = 36) with no coronary heart disease (CHD) to metabolize oxidized palmitoyl arachidonyl phosphatidylcholine (ox-PAPC), a major product of LDL oxidation and a PON1 substrate, with that of HDL isolated from healthy control subjects (n = 19) and people with CHD but no diabetes (n = 37).
|
17065348 |
2006 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We found that PON1 Arg 192 and ACE D alleles act synergistically to increase the risk of CAD in CAD patients and CAD subjects without diabetes from west of Iran, who have high frequency of three-vessel disease.
|
21681430 |
2012 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Low PON1 activities have been found in familial hypercholesterolemia (FH) and diabetes mellitus.
|
10978257 |
2000 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
There was a significant association between polymorphism C-108>T of PON1 and type2 diabetes mellitus, with 24.4% of control group subjects and 15.5% of patients having CC genotype; p<0.05.
|
28866115 |
2017 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
In this study, we evaluated the effect of boron (B) as boric acid (BA) on body weight (b.w.); blood glucose; plasma insulin; lipase and paraoxonase (PON1) activities; and serum triglyceride, total cholesterol, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, lipid peroxidation (MDA), and total antioxidant capacity (TAC) in streptozotocin (STZ)-induced experimental diabetes in rats.
|
29019104 |
2018 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
There were no differences in either the PON1 polymorphisms, PON1 activity and concentration in people with type 1 diabetes in the presence or absence of micro and macro vascular complications of diabetes.
|
11952811 |
2002 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
PON1 A(-162)G and PON2 Ala148Gly genotypes, cystatin C, HbA1c, high density lipoprotein cholesterol (HDLC), waist circumference (waist), and duration of diabetes were included in the regression analysis with log(e) (ln) of PON1 mass as the dependent variable.
|
19151417 |
2009 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In conclusion, we have shown that the Q192R polymorphism is a determinant of both PON1 concentration and activity and this association appeared to be enhanced in subjects with diabetes.
|
25477710 |
2014 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In the present study, the potential alterations in trace elements in morbidly obese women were assessed in relation to serum PON1 activity and concentration, as well as to other obesity-related comorbidities such as diabetes mellitus and fatty liver.
|
29773198 |
2018 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The observed interaction with type 2 diabetes, however, is supporting the hypothesis that the effect of the PON1 192 Arg allele on atherosclerosis is modulated by other risk factors like diabetes.
|
11409295 |
2001 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In multivariate analysis, PON1 paraoxonase activity was independently of confounding factors associated with diabetes (OR = 0.985; <i>p =</i> 0.024) and premature CHD in family history (OR = 0.983; <i>p =</i> 0.027).
|
30935088 |
2019 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Low serum paraoxonase1 (PON1) activity determined by paraoxon substrate is associated with coronary heart disease (CHD), diabetes and systemic lupus erythematosus (SLE) risk.
|
17900266 |
2008 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Genotyping of 156 Caucasian adolescents with diabetes for seven PON 1 polymorphisms was performed, including that of a novel PON 1 promoter polymorphism A(-1074)G. PON genotypes were related to paraoxonase and arylesterase activities and diabetes complication status.
|
16949520 |
2006 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The association of PON1 polymorphisms, lower PON1 activity and poorer diabetes control found in patients with macroangiopathy further support the idea of genetic factors contributing to the development of vascular disorders in diabetes.
|
17949258 |
2008 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The current data question the importance of PON-1 activity for the development of diabetes.
|
28732570 |
2017 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
PON activity was significantly decreased in Type 2 DM group compared to the control group.
|
19003935 |
2008 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The PON1 Q/R polymorphism was found to have significant association with hypertension (p=0.046) and chronic constipation (p=0.028) whereas, the L/M polymorphism, with diabetes (p=0.036), arteritis (trend p=0.022) and hemorrhoids (trend p=0.027).
|
19022366 |
2009 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our data suggest that PON1 Q192R polymorphism was not independently associated with MI but further increased the risk of MI among the subjects with DM, obesity, or both, the conditions associated with high oxidative stress.
|
15654230 |
2005 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Triglyceride levels (P = 0.0042), diabetes (P = 7.28 × 10(-5)), paraoxonase 1 (PON1) activity (P = 0.019), statin use (P = 0.026), PLTP SNP rs4810479 (P = 6.38 × 10(-7)), and PCIF1 SNP rs181914932 (P = 0.041) were all significantly associated with PLTPa.
|
26009633 |
2015 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
It has been reported that human serum paraoxonase (PON1) gene is associated with coronary heart disease (CHD) and diabetes mellitus (DM).
|
16808888 |
2006 |