Cleft upper lip
|
0.300 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Mutations in the Epithelial Cadherin-p120-Catenin Complex Cause Mendelian Non-Syndromic Cleft Lip with or without Cleft Palate.
|
29805042 |
2018 |
melanoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
PLEKHA5 expression in melanoma tumors was associated with early development of brain metastases.
|
25316811 |
2015 |
melanoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The impact of PLEKHA5 on proliferation and tumor growth was examined in vitro and in melanoma xenograft models, including brain-tropic melanomas (melanomas tending to disseminate to the brain).
|
31769872 |
2020 |
melanoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
PLEKHA5 functions as a regulator of brain metastasis in melanoma, and further investigation is warranted to explore the use of PLEKHA5 as a potential therapeutic target.
|
25779946 |
2015 |
Metastatic malignant neoplasm to brain
|
0.030 |
Biomarker
|
disease |
BEFREE |
At the protein level, by quantitative immunofluorescence, PLEKHA5 was associated with decreased brain metastasis-free survival.
|
25316811 |
2015 |
Metastatic malignant neoplasm to brain
|
0.030 |
Biomarker
|
disease |
BEFREE |
PLEKHA5 functions as a regulator of brain metastasis in melanoma, and further investigation is warranted to explore the use of PLEKHA5 as a potential therapeutic target.
|
25779946 |
2015 |
Metastatic malignant neoplasm to brain
|
0.030 |
Biomarker
|
disease |
BEFREE |
PLEKHA5 has previously been identified as a novel molecule implicated in melanoma brain metastasis, a disease that continues to portend a poor prognosis.
|
31769872 |
2020 |
Metastatic melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
PLEKHA5 regulates tumor growth in metastatic melanoma.
|
31769872 |
2020 |
Smoking
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.
|
26053186 |
2015 |
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Smoking Behaviors
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.
|
26053186 |
2015 |
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Knockdown of PLEKHA5 decreases the viability of A375Br cells, inhibits BBB transmigration and invasion in vitro.
|
25316811 |
2015 |
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Extensive search of the literature revealed a potential key role of genes at the identified porcine loci in tumor invasion (<i>DST</i>, PLEKHA5, <i>CBY1</i>, <i>LIMK2</i> and <i>ETV5</i>) and immune response modulation (<i>ETV5</i>, <i>HERC3</i> and <i>DICER1</i>) of the progression phenotypes.
|
29963229 |
2018 |
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The clinical relevance of PLEKHA5 dysregulation was further investigated in a cohort of matched cranial and extracranial melanoma metastases.
|
31769872 |
2020 |
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
PLEKHA5 expression in melanoma tumors was associated with early development of brain metastases.
|
25316811 |
2015 |
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
PLEKHA5 knockdown significantly inhibited tumor growth, whereas its overexpression upregulated the growth of tumors, which was induced by cranial and subcutaneous inoculation of cells in nude mice.
|
31769872 |
2020 |
Hematologic Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In this study, we revealed that PEPP2 gene was highly expressed in myeloid leukemia cells and some other hematological malignancies.
|
26784514 |
2016 |
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
The clinical relevance of PLEKHA5 dysregulation was further investigated in a cohort of matched cranial and extracranial melanoma metastases.
|
31769872 |
2020 |