Malignant neoplasm of breast
|
0.070 |
Biomarker
|
disease |
BEFREE |
Brn-3b is elevated in >65% of breast cancer biopsies, but mechanisms controlling its expression in these cells are not known.
|
21241485 |
2011 |
Malignant neoplasm of breast
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
To our knowledge, this is the first time that a Brn-3b POU family transcription factor has been shown to regulate a member of the catenin family, which provides insight into the molecular mechanisms by which Brn-3b expression may favour breast cancer progression and tumor invasion.
|
16152597 |
2006 |
Malignant neoplasm of breast
|
0.070 |
Biomarker
|
disease |
BEFREE |
POU4F2/Brn-3b transcription factor (referred to as Brn-3b) is elevated in >60% of breast cancers and profoundly alters growth and behaviour of cancer cells by regulating distinct subsets of target genes.
|
21279488 |
2011 |
Malignant neoplasm of breast
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
These results thus further indicate a role for the Brn-3b transcription factor in regulating mammary cell growth and suggest that its elevation in breast cancer is of functional significance.
|
11526481 |
2001 |
Malignant neoplasm of breast
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter.
|
15833836 |
2005 |
Malignant neoplasm of breast
|
0.070 |
Biomarker
|
disease |
BEFREE |
This review discusses the effect of altering Brn-3b in these cancer cells and possible approaches to targeting Brn-3b as a strategy for therapy in treatment of breast cancers.
|
16441225 |
2006 |
Malignant neoplasm of breast
|
0.070 |
Biomarker
|
disease |
BEFREE |
Thus, Brn-3b may act to alter growth properties of breast cancer and NB cells by enhancing CD1 expression in these cells.
|
17637757 |
2008 |
Breast Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Brn-3b is elevated in >65% of breast cancer biopsies, but mechanisms controlling its expression in these cells are not known.
|
21241485 |
2011 |
Breast Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
These results thus further indicate a role for the Brn-3b transcription factor in regulating mammary cell growth and suggest that its elevation in breast cancer is of functional significance.
|
11526481 |
2001 |
Breast Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Targeting Brn-3b in breast cancer therapy.
|
16441225 |
2006 |
Breast Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
To our knowledge, this is the first time that a Brn-3b POU family transcription factor has been shown to regulate a member of the catenin family, which provides insight into the molecular mechanisms by which Brn-3b expression may favour breast cancer progression and tumor invasion.
|
16152597 |
2006 |
Breast Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter.
|
15833836 |
2005 |
Breast Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Thus, Brn-3b may act to alter growth properties of breast cancer and NB cells by enhancing CD1 expression in these cells.
|
17637757 |
2008 |
Neuroblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We show that the 3'UTR of the Brn-3b mRNA does indeed contain regulatory sequences that mediate mRNA degradation upon serum starvation-induced differentiation of ND7 neuroblastoma cells.
|
17490655 |
2007 |
Neuroblastoma
|
0.040 |
AlteredExpression
|
disease |
LHGDN |
Thus, Brn-3b may act to alter growth properties of breast cancer and NB cells by enhancing CD1 expression in these cells.
|
17637757 |
2008 |
Neuroblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The Brn-3b POU domain transcription factor is elevated in a significant proportion of breast cancers and in neuroblastoma tumours, where it is associated with increased proliferation, anchorage-independent growth, faster and larger tumour growth in xenograft models, resistance to growth inhibitory stimuli and increased migratory potential.
|
16441225 |
2006 |
Neuroblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
We show a significant correlation between Brn-3b and cyclin D1 (CD1) in breast cancers and NB tumours and cell lines.
|
17637757 |
2008 |
Neuroblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Moreover, the level of Brn-3a rises and that of Brn-3b falls when neuroblastoma cell lines are exposed to treatments which induce a cessation of proliferation.
|
8782654 |
1996 |
Central neuroblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Moreover, the level of Brn-3a rises and that of Brn-3b falls when neuroblastoma cell lines are exposed to treatments which induce a cessation of proliferation.
|
8782654 |
1996 |
Central neuroblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The Brn-3b POU domain transcription factor is elevated in a significant proportion of breast cancers and in neuroblastoma tumours, where it is associated with increased proliferation, anchorage-independent growth, faster and larger tumour growth in xenograft models, resistance to growth inhibitory stimuli and increased migratory potential.
|
16441225 |
2006 |
Central neuroblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We show that the 3'UTR of the Brn-3b mRNA does indeed contain regulatory sequences that mediate mRNA degradation upon serum starvation-induced differentiation of ND7 neuroblastoma cells.
|
17490655 |
2007 |
Central neuroblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
We show a significant correlation between Brn-3b and cyclin D1 (CD1) in breast cancers and NB tumours and cell lines.
|
17637757 |
2008 |
Childhood Neuroblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The Brn-3b POU domain transcription factor is elevated in a significant proportion of breast cancers and in neuroblastoma tumours, where it is associated with increased proliferation, anchorage-independent growth, faster and larger tumour growth in xenograft models, resistance to growth inhibitory stimuli and increased migratory potential.
|
16441225 |
2006 |
Childhood Neuroblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Moreover, the level of Brn-3a rises and that of Brn-3b falls when neuroblastoma cell lines are exposed to treatments which induce a cessation of proliferation.
|
8782654 |
1996 |
Childhood Neuroblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
We show a significant correlation between Brn-3b and cyclin D1 (CD1) in breast cancers and NB tumours and cell lines.
|
17637757 |
2008 |