|
Colon Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Mechanistically, PHD2 overexpression obviously suppressed NF-κB activity through decreasing phosphorylated IκB-α while increasing cytoplasmic NF-κB p65 levels in colon cancer.
|
31838134 |
2020 |
|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
In this issue of the JCI, Yamamoto, Hester, and colleagues show that temporal and reversible inhibition of PHD2 in vivo leads to systemic autoimmune disorder.
|
31355780 |
2019 |
|
Heart failure
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In contrast, higher levels of Cer-22 were associated with lower risk of heart failure in multivariable analyses further adjusted for Cer-16 (hazard ratio, 0.85 [0.78-0.92]); and higher levels of SM-20, SM-22 and SM-24 were associated with lower risk of heart failure in analyses further adjusted for SM-16 (hazard ratios, 0.83 [0.77-0.90], 0.81 [0.75-0.88], and 0.83 [0.77-0.90], respectively).
|
31296099 |
2019 |
|
Congestive heart failure
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In contrast, higher levels of Cer-22 were associated with lower risk of heart failure in multivariable analyses further adjusted for Cer-16 (hazard ratio, 0.85 [0.78-0.92]); and higher levels of SM-20, SM-22 and SM-24 were associated with lower risk of heart failure in analyses further adjusted for SM-16 (hazard ratios, 0.83 [0.77-0.90], 0.81 [0.75-0.88], and 0.83 [0.77-0.90], respectively).
|
31296099 |
2019 |
|
Inflammatory Bowel Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Hence, this necessitates the development of new compounds capable of selectively inhibiting PHD-1 and PHD-2 for effective treatment of IBD.
|
31377947 |
2019 |
|
leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ER-INP was efficiently expressed and bound to PHD2 in cells, significantly increased the levels of HIF-1α, and decreased hydroxylated HIF-1α in human embryonic kidney cell line (HEK293) cells and mouse mononuclear macrophage leukaemia cell line (RAW264.7) cells.
|
31413262 |
2019 |
|
ovarian neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
ERK Regulates HIF1α-Mediated Platinum Resistance by Directly Targeting PHD2 in Ovarian Cancer.
|
31285371 |
2019 |
|
Ischemic stroke
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we found out that hif-prolyl hydroxylase 2 (PHD2) silencing could enhance the migration and survival ability of EPCs which could improve the therapy efficacy for ischemic stroke.
|
30677555 |
2019 |
|
Platinum-Resistant Ovarian Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, a novel TGFβ1/ERK/PHD2-mediated pathway regulating HIF1α stability in PROC was discovered.
|
31285371 |
2019 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
ERK Regulates HIF1α-Mediated Platinum Resistance by Directly Targeting PHD2 in Ovarian Cancer.
|
31285371 |
2019 |
|
Diabetic wound
|
0.010 |
Biomarker
|
disease |
BEFREE |
Acceleration of Diabetic Wound Healing with PHD2- and miR-210-Targeting Oligonucleotides.
|
29644938 |
2019 |
|
Enteritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We found that deletion of PHD2 in IECs did not lead to spontaneous enteritis or colitis in mice.
|
29688249 |
2018 |
|
Fatty Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of the present study is to investigate the regulatory role of prolyl hydroxylase-2 (PHD2)-hypoxia-inducible factor-2a (HIF-2α) axis on nonalcoholic fatty liver disease (NAFLD) and to explore the potential mechanisms by which endothelial (EC)-specific PHD2 deficiency regulates hepatic steatosis and fibrosis.
|
30036883 |
2018 |
|
Osteopenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, genetic ablation of PHD2 in osteocytes blunts osteoporotic bone loss induced by oestrogen deficiency or mechanical unloading.
|
29967369 |
2018 |
|
Squamous cell carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Elevated PHD2 expression might only serve as a valuable biomarker of poor prognosis in LUAD, but no in LUSC.
|
30575913 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Elevated PHD2 expression might only serve as a valuable biomarker of poor prognosis in LUAD, but no in LUSC.
|
30575913 |
2018 |
|
Non-alcoholic Fatty Liver Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of the present study is to investigate the regulatory role of prolyl hydroxylase-2 (PHD2)-hypoxia-inducible factor-2a (HIF-2α) axis on nonalcoholic fatty liver disease (NAFLD) and to explore the potential mechanisms by which endothelial (EC)-specific PHD2 deficiency regulates hepatic steatosis and fibrosis.
|
30036883 |
2018 |
|
Tumor Initiation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These data indicate that PHD2 is capable of suppressing tumor initiation largely mediated through inhibiting of the Akt-mTOR signaling pathway in the melanocyte lineage.
|
30575721 |
2018 |
|
Oestrogen deficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, genetic ablation of PHD2 in osteocytes blunts osteoporotic bone loss induced by oestrogen deficiency or mechanical unloading.
|
29967369 |
2018 |
|
Increased Cellularity Present
|
0.010 |
Biomarker
|
disease |
BEFREE |
Histologic studies revealed increased blood vessel density and increased cellularity in the wounds treated with PHD-2 knockdown mesenchymal stromal cells (p < 0.05).
|
29280872 |
2018 |
|
Steatohepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of the present study is to investigate the regulatory role of prolyl hydroxylase-2 (PHD2)-hypoxia-inducible factor-2a (HIF-2α) axis on nonalcoholic fatty liver disease (NAFLD) and to explore the potential mechanisms by which endothelial (EC)-specific PHD2 deficiency regulates hepatic steatosis and fibrosis.
|
30036883 |
2018 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The mTOR and PP2A Pathways Regulate PHD2 Phosphorylation to Fine-Tune HIF1α Levels and Colorectal Cancer Cell Survival under Hypoxia.
|
28199842 |
2017 |
|
Fenestration (morphologic abnormality)
|
0.010 |
Biomarker
|
disease |
BEFREE |
A tissue-engineered compound was constructed using the composite collagen membrane of BMMSCs after PHD2 gene silencing to repair periodontal fenestration defects in SD rats.
|
29069818 |
2017 |
|
Hypernatremia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Our results demonstrated that inhibition of miR-429 remarkably increased the levels of PHD2, which disrupted PHD2-associated adaptive activation of HIF-1α-mediated gene expression in response to high salt in the renal medulla and consequently inhibited urinary sodium excretion, enhanced sodium retention in response to chronic sodium overloading, and as a result, produced a salt-sensitive hypertension.
|
28445205 |
2017 |
|
Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
We hypothesized that PHD2 inhibition would restore vigorous muscle regeneration in a murine model of obesity.
|
28725215 |
2017 |