|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results indicated that obesity is not associated with alteration in PPAR gene expression in abdominal subcutaneous adipose tissue in humans.
|
9231657 |
1997 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The objectives of the present investigation were to examine: 1) whether a Pro115Gln variant in the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) is associated with juvenile-onset obesity among Danish Caucasianmen and 2) whether the relation of a Pro12Ala polymorphism in PPAR-gamma2 with BMI and long-term weight regulation differ between lean and obese subjects within the same cohort.
|
10440134 |
1999 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
CTD_human |
Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice.
|
11089532 |
2000 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The peroxisome proliferator-activated receptor-gamma2 (PPAR(gamma2)) represents the transcriptional master regulator of adipocyte differentiation and therefore has been suggested as candidate gene for the pathogenesis of obesity, type 2 diabetes and related metabolic disorders.
|
11928067 |
2002 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Several polymorphisms have been associated with lipid metabolism and obesity: PPAR-gamma2-Pro115Gln, PPARgamma2-Pro12Ala, beta3AR-Trp64Arg and SR-BI IVS5 C > T. We examined the frequency of these polymorphisms in patients with a BMI > 40 and compared them to individuals with a BMI < 30.
|
12568179 |
2002 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Aims of this study were to estimate the allele frequency of the Pro12Ala polymorphism of PPAR gamma2 gene among native Javanese in Indonesia and to investigate the relationship between this polymorphism and obesity or diabetes.
|
15739197 |
2005 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
PPARalpha deficiency did not influence the growth curves of the obese mice but surprisingly resulted in a severe, age-dependent hyperglycemia.
|
16731822 |
2006 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, in a relative large-scale study of middle-aged whites we found no evidence of association between the PPARalpha Leu162Val polymorphism and obesity or type 2 diabetes.
|
17129741 |
2007 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
While candidate gene approaches have not been tremendously successful in identifying relevant genetic contributors to obesity, except PPAR , the advent of genome-wide strategies has recently revealed novel and unexpected genetic factors with strong associations with obesity and/or diabetes, i.e.
|
18230892 |
2008 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, whether PPARalpha agonism is an effective form of therapy for obesity-related insulin resistance associated with lipid abnormalities is unclear.
|
18212024 |
2008 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Studies on the association of the Pro12Ala and C1431T polymorphisms of PPAR? with diabetes and obesity have revealed extensive population-dependent variations.
|
19805902 |
2009 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We conclude that despite the high frequency of the Ala allele at the PPAR-gamma2 gene in our population of Polish men, the Ala12 allele does not appear to improve insulin sensitivity or have an influence on the occurrence of obesity.
|
18777501 |
2009 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Estrogen inhibits the actions of PPARalpha on obesity and lipid metabolism through its effects on PPARalpha-dependent regulation of target genes.
|
19646654 |
2009 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The increased insulin sensitivity in the VLCAD(-/-) mice were protected from diet-induced obesity and insulin resistance due to chronic activation of AMPK and PPARalpha, resulting in increased fatty acid oxidation and decreased intramyocellular and hepatocellular diacylglycerol content.
|
20444420 |
2010 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Because PPARA plays a central role in fatty acid homeostasis, and in the transcriptional regulation of genes that are necessary for maintenance of the redox balance during the oxidative catabolism of fatty acids, we suggest that PPARA loss and miR-519d overexpression could be associated with metabolic imbalance and subsequent adipocyte hypertrophy in SAT during obesity.
|
20057369 |
2010 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To investigate the differences in cultivable gut bacteria and peroxisome proliferator-activated receptor γ2 (PPAR-γ2) gene Pro12Ala variation in obese and normal-weight Chinese people.
|
21448362 |
2011 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The association between PPAR-gamma2 Prol2Ala polymorphism and glucose metabolism is already present in children and adolescents with obesity who might be at the very beginning of the natural course of type 2 diabetes.
|
21528816 |
2011 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
These associations showed that high expression levels of CPT1A, SLC27A2, INSR, FASN, or PPARα may be indicative of a lower risk for the insulin-resistant or dyslipidemic state associated with obesity, whereas low LEPR mRNA levels appear as a marker of high low-density lipoprotein cholesterol, independently of body mass index.
|
22278432 |
2012 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Association of peroxisome proliferator-activated receptor α/δ/γ with obesity, and gene-gene interaction, in the Chinese Han population.
|
23545576 |
2013 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results show that Amerindians do not have association of PPAR-γ2 Ala12 and obesity; the latter was measured by waist circumference values after taken specific Amerindian normal waist parameters.
|
23096090 |
2013 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The high-fat lard diet induces obesity and fatty liver in C57BL/6J mice and suppresses expression of the PPAR-target gene, FA elongase 5 (Elovl5).
|
24814977 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Effect of obesity on the association between common variations in the PPAR gene and C-reactive protein level in Chinese Han population.
|
24599720 |
2015 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This study aimed to evaluate the differences in the expression of PPARα target genes in human peripheral blood mononuclear cells (PBMCs) and free fatty acids (FFA) in obese and non-obese individuals after 24 h of fasting.
|
25500634 |
2015 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this meta-analysis was to acquire a more accurate assessment of the association between PPAR-γ2 Pro12Ala polymorphism and obesity.
|
25502405 |
2015 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Oleoylethanolamine (OEA), an endogenous high-affinity agonist of peroxisome proliferator-activated receptor alpha (PPAR-α), has revealed the pharmacological properties in the treatment of obesity, atherosclerosis and other diseases through the modulation of lipid metabolism.
|
25837920 |
2015 |