|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Our research has confirmed an association between the pro12ala allele and reduced incidence of obesity in pre-pubertal children and there are strong associations between genetic variation at the PPARG locus and percentage body fat.
|
16777151 |
2006 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The Pro12Ala Single Nucleotide Polymorphism (SNP) of the Peroxisome Proliferator-Activated Receptor gamma 2 (PPAR-gamma 2) has been associated with insulin resistance and type 2 diabetes (T2D) and also inconsistently with obesity.
|
15784141 |
2005 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The PPARG rs1801282 (G/C) polymorphism has been associated with OSA in obese Indian subjects, whereas no such association has been reported in Chinese Han subjects.
|
31044373 |
2019 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The PPARgamma Pro12Ala polymorphism has been associated in several studies with a decreased risk of obesity, type 2 diabetes and insulin resistance.
|
17408525 |
2007 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPARgamma-2) gene has been variably associated with insulin resistance, obesity and type 2 diabetes in several populations.
|
17439324 |
2007 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The association of the C1431T silent mutation and the Pro12Ala missense transversion within the PPARgamma gene with the development of T2DM or obesity has often yielded contradictory results.
|
18250615 |
2007 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Interaction between peroxisome proliferator-activated receptor gamma polymorphism and obesity on type 2 diabetes in a Chinese Han population.
|
28123453 |
2017 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Characterisation of non-obese diabetic patients with marked insulin resistance identifies a novel familial partial lipodystrophy-associated PPARγ mutation (Y151C).
|
21479595 |
2011 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The measured parameters for mothers and their newborns were risk percentage for child obesity, anthropometric characteristics (mid-upper arm circumference [MUAC], tricipital skinfold thickness [TST] of mother and newborn), genetic polymorphisms (human peroxisome proliferator-activated receptor γ [PPARγ2] 34 C > G and transforming growth factor-beta 1 [TGF-β1] 869 T > C gene polymorphisms in both mothers and newborns), and mother's bioimpedance characteristics (fat mass [FM] %).The obesity risk score according to standard predictable Northern Finland Birth Cohort equation was in our study 4.07%.
|
27442659 |
2016 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The peroxisome proliferator-activated receptor gamma 2 (PPARγ2) genotypes are related to obesity and the metabolic syndrome (MetS).
|
21156835 |
2011 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The association of 17 candidate single nucleotide polymorphisms (SNPs) in IL10 and other immune response genes (CRP, TLR4, IL6, IL1B, IL8, TNF, RNASEL) and genes related to obesity (PPARG, TCF7L2, ADIPOQ, LEP) with colorectal cancer was investigated.
|
19760027 |
2009 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Beta3AR Trp64Arg and PPARgamma2 Pro12Ala polymorphisms might be associated with insulin resistance and obesity, and there might be slight synergistic effects between this two gene loci, and further studies are necessary to confirm this finding.
|
17624182 |
2007 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
PPAR-γ gene polymorphism is associated with and increased the risk of psoriasis and its associated obesity in Egyptian patients.
|
31148857 |
2020 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of the peroxisome proliferator-activated receptor-γ (rs1801282) and its coactivator-1 (rs8192673) are associated with obesity indexes in subjects with type 2 diabetes mellitus.
|
25928419 |
2015 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
ACDC/adiponectin and PPAR-gamma gene polymorphisms: implications for features of obesity.
|
16421345 |
2005 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The PPARG proline for alanine substitution at position 12 (Pro12Ala polymorphism) has been related with obesity directly and via interaction with PUFA.
|
17898990 |
2007 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the peroxisome proliferator-activated receptor-gamma 2 (PPAR-gamma 2) gene may cause obesity and insulin resistance.
|
12746759 |
2003 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor-α (TNF-α), peroxisome proliferator-activated receptor-γ (PPARγ), and insulin receptor substrate-1 (IRS-1) are associated with obesity, insulin resistance, and inflammation.
|
29256014 |
2018 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The PPARG rs1801282 SNP did not exhibit any significant association with obesity among the complete sample population.
|
25182148 |
2015 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Screening for mutations in the entire coding region of the PPAR gamma gene (both gamma 1 and gamma 2 isoforms) was performed with DNA of 26 diabetic Caucasians with or without obesity.
|
9425261 |
1997 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
In a Mexican population characterized by high-fat consumption, we hypothesized that the Pro12Ala PPARγ genotype is related to obesity and this relationship is modulated by intake of saturated fatty acids (SFAs) and trans-fatty acids (TFAs).
|
30122193 |
2018 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The peroxisome proliferator-activated receptor gamma 2 (PPARG2) gene has been intensively studied with relation to obesity and metabolic disorders.
|
23666678 |
2013 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The 482Ser of PPARGC1A and 12Pro of PPARG2 Alleles Are Associated with Reduction of Metabolic Risk Factors Even Obesity in a Mexican-Mestizo Population.
|
26185753 |
2015 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Effect of the peroxisome proliferator-activated receptor-gamma 2 pro(12)ala variant on obesity, glucose homeostasis, and blood pressure in members of familial type 2 diabetic kindreds.
|
11158005 |
2001 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-gamma 2 is associated with combined hyperlipidaemia in obesity.
|
11248748 |
2001 |