|
Adenocarcinoma of rectum
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The regulatory role of SLP-2 gene on CCBE1 expression in RC tumor and adjacent lymphatic tube tissues, however, has not been studied.
|
29364474 |
2018 |
|
Adenoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
SLP-2 immunohistochemical expression was not detected in benign adenomas and was absent/weak in follicular and anaplastic carcinomas.
|
26750533 |
2016 |
|
Adult Liver Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We further measured the several types of the malignant transformation of SK-Hep1 cells to assess the effects of SLP-2 silencing on the cell migration and invasion, proliferation and angiogenesis of liver cancer in vitro.
|
31571899 |
2019 |
|
Anaplastic carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SLP-2 immunohistochemical expression was not detected in benign adenomas and was absent/weak in follicular and anaplastic carcinomas.
|
26750533 |
2016 |
|
Angioedema
|
0.100 |
CausalMutation
|
phenotype |
CLINVAR |
|
|
|
|
Benign Neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The results of immunohistochemistry showed that the positive expression rate of SLP-2 protein in the malignant tumor group was significantly higher than that in the benign tumor and control groups (P<0.001).
|
30944651 |
2019 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Evaluation and application of summary statistic imputation to discover new height-associated loci.
|
29782485 |
2018 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Cell growth changes with the sense and antisense transfection revealed that SLP-2 might be important in endometrial tumorigenesis.
|
17342323 |
2007 |
|
Carcinogenesis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
In the present study, we aimed to explore the diagnostic value of SLP-2 in patients with PTC and to investigate whether SLP-2 expression is regulated by transforming growth factor-β (TGF-β), a cytokine which plays an important role in PTC tumorigenesis.
|
24190591 |
2014 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Results from tissue microarray in this study and our previous reports revealed that stomatin-like protein 2 (SLP-2) is notably associated with tumorigenesis and metastasis.
|
19597348 |
2009 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Decreased cell growth, cell adhesion, and tumorigenesis in the antisense transfectants revealed that SLP-2 may be important in tumorigenesis.
|
16533792 |
2006 |
|
Carcinoma of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
We show here the involvement of SLP-2 in human esophageal squamous cell carcinoma (ESCC), lung cancer, laryngeal cancer, and endometrial adenocarcinoma and the effects of SLP-2 on ESCC cells.
|
16533792 |
2006 |
|
Carcinoma of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
SLP-2 was overexpressed in lung cancer compared with normal lung tissue (p <0.001).
|
19839737 |
2010 |
|
Carcinoma, Ovarian Epithelial
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
SLP-2 expression was investigated in eight matched-pair samples of epithelial ovarian cancer and adjacent noncancerous tissues from the same patients.
|
26487491 |
2015 |
|
Carcinoma, Ovarian Epithelial
|
0.030 |
Biomarker
|
disease |
BEFREE |
Synaptotagmin-like protein 2 gene promotes the metastatic potential in ovarian cancer.
|
27220283 |
2016 |
|
Carcinoma, Ovarian Epithelial
|
0.030 |
Biomarker
|
disease |
BEFREE |
SLP-2 may be involved in the occurrence and development of ovarian cancer and related to the clinical stage, pathological differentiation and lymph node metastasis of the patients with ovarian cancer, which may also play a role in promoting the invasion and metastasis processes of ovarian cancer.
|
30944651 |
2019 |
|
cervical cancer
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Stomatin-like protein 2 (STOML2 or SLP-2) is an oncogenic anti-apoptotic protein that is upregulated in several types of cancer, including cervical cancer.
|
29516570 |
2018 |
|
cervical cancer
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The results indicated that SLP-2 expression in cervical cancer was significantly upregulated at the mRNA and protein levels, compared with that in normal cervical tissues.
|
29181097 |
2017 |
|
Cervix carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The results indicated that SLP-2 expression in cervical cancer was significantly upregulated at the mRNA and protein levels, compared with that in normal cervical tissues.
|
29181097 |
2017 |
|
Cervix carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Stomatin-like protein 2 (STOML2 or SLP-2) is an oncogenic anti-apoptotic protein that is upregulated in several types of cancer, including cervical cancer.
|
29516570 |
2018 |
|
Chemical and Drug Induced Liver Injury
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study.
|
28043905 |
2017 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present study identified that SLP-2 may predict a poor prognosis in CRC patients as a novel marker, and SLP-2 may facilitate the migration and invasion of CRC via regulating Wnt/β-catenin pathway activities.
|
30389319 |
2019 |
|
Cystic Fibrosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Thus, the objective of this study was to evaluate the respiratory dynamics of healthy control subjects and those with cystic fibrosis in a submaximal exercise protocol for six minutes on the treadmill, using volumetric capnography parameters (slope 3 [Slp3], Slp3/tidal volume [Slp3/TV], and slope 2 [Slp2]).
|
29195083 |
2019 |
|
Deciduoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Mice with artificially induced deciduoma showed significantly higher expression of Slp-2 compared with uninduced controls (P < 0.005).
|
27986413 |
2017 |
|
Endometrial adenocarcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
SLP-2 was overexpressed in endometrial adenocarcinoma compared with their normal counterparts (P<or=0.05).
|
17342323 |
2007 |