|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
It is concluded that CYP2W1 represents a tumor-specific P450 isoform with potential importance as a drug target in cancer therapy.
|
16426568 |
2006 |
|
Primary malignant neoplasm
|
0.060 |
AlteredExpression
|
group |
BEFREE |
CYP2W1 is a novel enzyme shown to be selectively expressed in rat fetal colon and in human colon cancer and has previously been suggested as a potential drug target for cancer therapy.
|
17979506 |
2007 |
|
Primary malignant neoplasm
|
0.060 |
AlteredExpression
|
group |
BEFREE |
The analysis of colorectal normal and cancer tissues and CYP2W1 overexpressing human embryonic kidney (HEK) 293 cells showed that a fraction of CYP2W1 is modified by N-glycosylation.
|
20805301 |
2010 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
The selective expression in some forms of cancers and the low expression in normal tissues render CYP2W1 as a possible drug target during cancer therapy.
|
17150034 |
2007 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
Cytochrome P450 2W1 (CYP2W1) is a colon tumor-specific enzyme, suggested as a potential target for cancer therapy.
|
26787547 |
2016 |
|
Malignant tumor of colon
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
CYP2W1 is a novel enzyme shown to be selectively expressed in rat fetal colon and in human colon cancer and has previously been suggested as a potential drug target for cancer therapy.
|
17979506 |
2007 |
|
Malignant tumor of colon
|
0.050 |
Biomarker
|
disease |
BEFREE |
Membrane topology and search for potential redox partners of colon cancer-specific cytochrome P450 2W1.
|
26787547 |
2016 |
|
Malignant tumor of colon
|
0.050 |
Biomarker
|
disease |
BEFREE |
This information thus underline the colon cancer specificity of CYP2W1 enzyme expression and has implications for the development of anti-colon cancer therapies based on CYP2W1 as a drug target, since 2W1-dependent bioactivation of prodrugs for CYP2W1 will not take place in normal adrenal tissue or other non-transformed tissues.
|
27598485 |
2016 |
|
Malignant tumor of colon
|
0.050 |
Biomarker
|
disease |
BEFREE |
Together, these results suggest the possibility of using CYP2W1 as a drug target in the treatment of colon cancer using antibodies and/or specific CYP2W1 activated prodrugs.
|
20805301 |
2010 |
|
Malignant tumor of colon
|
0.050 |
Biomarker
|
disease |
BEFREE |
Cells expressing CYP2W1 suffer rapid loss of viability following treatment with ICT2705 and ICT2706, whereas the CYP2W1-positive human colon cancer xenografts display arrested growth in the mice treated with ICT2706.
|
23589180 |
2013 |
|
Colon Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Membrane topology and search for potential redox partners of colon cancer-specific cytochrome P450 2W1.
|
26787547 |
2016 |
|
Colon Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Cells expressing CYP2W1 suffer rapid loss of viability following treatment with ICT2705 and ICT2706, whereas the CYP2W1-positive human colon cancer xenografts display arrested growth in the mice treated with ICT2706.
|
23589180 |
2013 |
|
Colon Carcinoma
|
0.050 |
PosttranslationalModification
|
disease |
BEFREE |
Here, the expression and gene methylation of CYP2W1 were analyzed in human colon carcinoma cell lines, colon tumors and in corresponding normal colon tissue.
|
17979506 |
2007 |
|
Colon Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
This information thus underline the colon cancer specificity of CYP2W1 enzyme expression and has implications for the development of anti-colon cancer therapies based on CYP2W1 as a drug target, since 2W1-dependent bioactivation of prodrugs for CYP2W1 will not take place in normal adrenal tissue or other non-transformed tissues.
|
27598485 |
2016 |
|
Colon Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Together, these results suggest the possibility of using CYP2W1 as a drug target in the treatment of colon cancer using antibodies and/or specific CYP2W1 activated prodrugs.
|
20805301 |
2010 |
|
Malignant neoplasm of colon and/or rectum
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
CYP2W1 variant alleles in Caucasians and association of the CYP2W1 G541A (Ala181Thr) polymorphism with increased colorectal cancer risk.
|
20602611 |
2010 |
|
Malignant neoplasm of colon and/or rectum
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
CYP2W1 polymorphism: functional aspects and relation to risk for colorectal cancer.
|
24088132 |
2013 |
|
Malignant neoplasm of colon and/or rectum
|
0.040 |
Biomarker
|
disease |
BEFREE |
Colorectal cancer-specific cytochrome P450 2W1: intracellular localization, glycosylation, and catalytic activity.
|
20805301 |
2010 |
|
Malignant neoplasm of colon and/or rectum
|
0.040 |
Biomarker
|
disease |
BEFREE |
CYP2W1 expression level was suggested to serve as an independent prognostic biomarker in colorectal cancer and hepatocellular carcinoma.
|
27690753 |
2017 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to determine the mRNA expression patterns of four cytochrome P450 genes (CYP2W1, 3A5, 4F11 and 8A1) in Mexican women with breast cancer.
|
22938436 |
2012 |
|
Malignant neoplasm of breast
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Expression of CYP2S1 and CYP2W1 in breast cancer epithelial cells and modulation of their expression by synthetic methoxy stilbenes.
|
31561186 |
2019 |
|
Malignant neoplasm of breast
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
In this report, and for the first time in the literature, we analyzed the rs3735684 (7021 G>A), rs11553651 (15016 G>T) and rs56195291 (60020 C>G) polymorphisms in the CYP2W1, 4F11 and 8A1 genes in patients with BCa and in healthy Mexican women to identify a potential association between these polymorphisms and BCa risk.
|
22631658 |
2012 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Expression of CYP2S1 and CYP2W1 in breast cancer epithelial cells and modulation of their expression by synthetic methoxy stilbenes.
|
31561186 |
2019 |
|
Breast Carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
In this report, and for the first time in the literature, we analyzed the rs3735684 (7021 G>A), rs11553651 (15016 G>T) and rs56195291 (60020 C>G) polymorphisms in the CYP2W1, 4F11 and 8A1 genes in patients with BCa and in healthy Mexican women to identify a potential association between these polymorphisms and BCa risk.
|
22631658 |
2012 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to determine the mRNA expression patterns of four cytochrome P450 genes (CYP2W1, 3A5, 4F11 and 8A1) in Mexican women with breast cancer.
|
22938436 |
2012 |