|
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
As a consequence of this, there is a low level of endogenous tumor suppressor protein SMAR1 in breast cancer-derived cell lines.
|
17726044 |
2007 |
|
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
As a consequence of this, there is a low level of endogenous tumor suppressor protein SMAR1 in breast cancer-derived cell lines.
|
17726044 |
2007 |
|
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we show that downmodulation of SMAR1 in high grade breast carcinoma is correlated with upregulated Cyclin D1 expression.
|
17668048 |
2007 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
SMAR1-downregulated CD8+T cells were injected into 4T1 tumor-bearing mice through the caudal vein, and the growth of tumor in mice was monitored.
|
30301506 |
2018 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Our study reveals for the first time, the molecular mechanism associated with lower levels of expression of the important tumor suppressor SMAR1 in higher grades of breast cancer.
|
28617439 |
2017 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
In this review, we focus on one of such nuclear protein known as tumor suppressor and scaffold matrix attachment region-binding protein 1 (SMAR1) in CD4<sup>+</sup> T cell differentiation.
|
28232831 |
2017 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Enhanced expression of SMAR1 in tumors will help to improve the clinical efficiency of radiation therapy.
|
26629941 |
2014 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
These results indicate a crucial role for SMAR1 in restraining breast cancer cell migration and suggest the candidature of this scaffold matrix-associated region-binding protein as a tumor suppressor.
|
25086032 |
2014 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Earlier, we have shown that tumor suppressor SMAR1 suppresses NF-κB transcriptional activity by modulating IκBα function.
|
25239884 |
2014 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Heat-shock protein 70 binds to a novel sequence in 5' UTR of tumor suppressor SMAR1 and regulates its mRNA stability upon Prostaglandin A2 treatment.
|
20153327 |
2010 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Therefore, the results presented here highlight the mechanism of Cytokeratin 8 gene regulation by interplay of tumor suppressor proteins SMAR1 and p53.
|
18822384 |
2009 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Direct interaction with and activation of p53 by SMAR1 retards cell-cycle progression at G2/M phase and delays tumor growth in mice.
|
12494467 |
2003 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
SMAR1 favors immunosurveillance of cancer cells by modulating calnexin and MHC I expression.
|
31422285 |
2019 |
|
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
SMAR1 favors immunosurveillance of cancer cells by modulating calnexin and MHC I expression.
|
31422285 |
2019 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Recently, circular RNAs (circRNAs) attract much attention due to their potential vital functions in multiple human diseases, including cancer. circ-BANP has been reported to modulate colorectal cancer growth.
|
29969631 |
2018 |
|
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
Recently, circular RNAs (circRNAs) attract much attention due to their potential vital functions in multiple human diseases, including cancer. circ-BANP has been reported to modulate colorectal cancer growth.
|
29969631 |
2018 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Interestingly, Cdc20-mediated degradation of SMAR1 promotes cell migration and invasion.The reciprocal relationship of the duo is evident in breast cancer cell lines as well as in patient samples, suggesting that Cdc20 functions as an important negative regulator of SMAR1 in higher grades of cancer.
|
28617439 |
2017 |
|
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
Interestingly, Cdc20-mediated degradation of SMAR1 promotes cell migration and invasion.The reciprocal relationship of the duo is evident in breast cancer cell lines as well as in patient samples, suggesting that Cdc20 functions as an important negative regulator of SMAR1 in higher grades of cancer.
|
28617439 |
2017 |
|
Malignant Neoplasms
|
0.070 |
GeneticVariation
|
group |
BEFREE |
SMAR1 gene is located on human chromosome 16q24.3 locus, the loss of heterozygosity (LOH) of which has been reported in several types of cancers.
|
20709157 |
2011 |
|
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
Gene regulation by SMAR1: Role in cellular homeostasis and cancer.
|
20709157 |
2011 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Evaluation of SMAR1 and Cytokeratin 8 proteins in different grades of cancer using tissue microarray point out at the inverse expression profiles of these genes (i.e. low levels of SMAR1 correlating with high expression of Cytokeratin 8) in higher grades of breast cancer.
|
18822384 |
2009 |
|
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
Evaluation of SMAR1 and Cytokeratin 8 proteins in different grades of cancer using tissue microarray point out at the inverse expression profiles of these genes (i.e. low levels of SMAR1 correlating with high expression of Cytokeratin 8) in higher grades of breast cancer.
|
18822384 |
2009 |
|
Malignant Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Our studies provide a mechanistic insight into the regulation of tumor suppressor protein SMAR1 by a cancer therapeutic PGA2, that leads to repression of Cyclin D1 gene.
|
17726044 |
2007 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
p53 target gene SMAR1 is dysregulated in breast cancer: its role in cancer cell migration and invasion.
|
17668048 |
2007 |
|
Primary malignant neoplasm
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Our studies provide a mechanistic insight into the regulation of tumor suppressor protein SMAR1 by a cancer therapeutic PGA2, that leads to repression of Cyclin D1 gene.
|
17726044 |
2007 |