Steatohepatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.
|
21459323 |
2011 |
Steatohepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, these results indicate that MIF is highly expressed in the liver during physical exercise and may prevent hepatic steatosis by activating the AMPK pathway.
|
23823021 |
2013 |
Steatohepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, fAd also showed suppression of palmitate-induced fetuin-A through the AMPK pathway and improvement of steatosis accompanied by restoration of SREBP-1c, PAPR-α and CD36.
|
23948064 |
2013 |
Steatohepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis.
|
24486702 |
2014 |
Steatohepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results provide new insights into the negative regulation of miR-451 in fatty acid-induced inflammation via the AMPK/AKT pathway and demonstrate potential therapeutic applications for miR-451 in preventing the progression from simple steatosis to severely advanced liver disease.
|
25957914 |
2015 |
Steatohepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results demonstrate that AS-IV attenuates FFA-induced ER stress and lipid accumulation in an AMPK-dependent manner in hepatocytes, which supports its use as promising therapeutics for hepatic steatosis.
|
28344322 |
2017 |
Steatohepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pectic Bee Pollen Polysaccharide from Rosa rugosa Alleviates Diet-Induced Hepatic Steatosis and Insulin Resistance via Induction of AMPK/mTOR-Mediated Autophagy.
|
28452943 |
2017 |
Steatohepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Apelin protects against liver X receptor-mediated steatosis through AMPK and PPARα in human and mouse hepatocytes.
|
28821440 |
2017 |
Steatohepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
AMPK activation caused by reduced liver lactate metabolism protects against hepatic steatosis in MCT1 haploinsufficient mice.
|
29092796 |
2017 |
Steatohepatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, DHA-induced activations of G<sub>q/11</sub> proteins, CaMKK, and AMPK were found to be signaling components of the steatosis protective pathway.
|
29126901 |
2018 |
Steatohepatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that serine supplementation could prevent HF diet-induced oxidative stress and steatosis by epigenetically modulating the expression of glutathione synthesis-related genes and through AMPK activation.
|
29158183 |
2018 |
Steatohepatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, activation of AMPK by metformin causes an augmentation of Insig stability and reduction of lipogenic gene expression, and leads to the attenuation of hepatic steatosis in HFHS diet-fed mice.
|
30733434 |
2019 |
Steatohepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The knockdown of LXR protected against steatosis but failed to change phosphorylated AMPK.
|
30972177 |
2019 |
Steatohepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data provided new evidence supporting the preventive role of 500 mg/(kg·bw·day) APE treatment in the HFD-induced hepatic steatosis in C57BL/6 mice via the LKB1/AMPK pathway.
|
31608624 |
2019 |
Steatohepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings revealed that diminished AMPK/TFEB-dependent autophagy is involved in the pathogenesis of liver steatosis in obesity, and that CAT might be a novel therapeutic candidate for treatment of this condition.
|
31697646 |
2019 |