|
Hypercholesterolemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Subjects from the MENA cohort (n=474) were categorized according to age (<45 vs 45>) and the presence of metabolic alterations: increased waist circumference, hypercholesterolemia, insulin resistance, and metabolic syndrome.
|
30926763 |
2019 |
|
IGA Glomerulonephritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The enabled homolog gene polymorphisms are associated with susceptibility and progression of childhood IgA nephropathy.
|
19641378 |
2009 |
|
Influenza
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Meeting participants concluded that influenza remains a significant threat especially in high-risk groups (children under-5, elderly, pregnant women and immunosuppressed individuals) in the MENA-ISN region.
|
30801995 |
2019 |
|
Leukemia, Myelocytic, Acute
|
0.300 |
Biomarker
|
disease |
CTD_human |
The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias.
|
26237430 |
2015 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The expression of Mena protein in 81 specimens of HCC tissues was determined by immunohistochemistry.
|
24683008 |
2014 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
A high MENA protein level was associated with high mRNA levels of MENA, CD133, cytokeratin 19 (CK19), and epithelial cell adhesion molecule (EpCAM) in human HCC tissues.
|
28781954 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.050 |
Biomarker
|
disease |
BEFREE |
The presence of anti-ENA and anti-dsDNA autoantibodies in SLE patients was associated with elevated levels of TLR7 and TLR9 respectively.
|
23564191 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.050 |
Biomarker
|
disease |
BEFREE |
Systemic lupus erythematosus (SLE) patients have anti-nuclear autoantibodies directed against dsDNA and RNA-associated antigens (extractable nuclear antigens; ENA).
|
24659206 |
2014 |
|
Lupus Erythematosus, Systemic
|
0.050 |
Biomarker
|
disease |
BEFREE |
These results might suggest that Italian patients with SLE are, at least in part, different from lupus patients living in other geographical areas and suggest the association of DQw2 with the autoantibody response to ENA in SLE.
|
1954698 |
1991 |
|
Lupus Erythematosus, Systemic
|
0.050 |
Biomarker
|
disease |
BEFREE |
ACA = anti-cardiolipin antibodies; ANF = anti-nuclear factor; anti-CCP = anti-cyclic citrullinated peptide; anti-dsDNA = anti-double-stranded DNA; anti-RNP = anti-ribonucleoprotein; anti-Scl70 = anti-topoisomerase I antibodies; anti-SM = anti-Smith antigen antibodies; anti-SS-A/Ro = anti-Sjögren syndrome-related antigen A (Ro); anti-SS-B/La = anti-Sjögren syndrome-related antigen B (La); anti-Tg = anti-thyroglobulin; anti-TPO = anti-thyroid peroxidase; ATD = autoimmune thyroid disease; ENA = extractable nuclear antigen; fT4 = free thyroxine; OR = odds ratio; RF = rheumatoid factor; SLE = systemic lupus erythematosus; SLEDAI = SLE Disease Activity Index; TD = thyroid dysfunction; TSH = thyroid-stimulating hormone; TT3 = total triiodothyronine.
|
28816533 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.050 |
Biomarker
|
disease |
BEFREE |
Anti-dsDNA antibodies were higher in SLE and ENA showed the highest titers in MCTD.
|
30807792 |
2019 |
|
Malignant neoplasm of breast
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The expression of ENAH isoform 11a has been shown to be elevated in breast cancers that express HER2.
|
26149387 |
2015 |
|
Malignant neoplasm of breast
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Loss of CLK2 in luminal breast cancer cells leads to the upregulation of epithelial-to-mesenchymal transition (EMT)-related genes and a switch to mesenchymal splice variants of several genes, including ENAH (MENA).
|
25670169 |
2015 |
|
Malignant neoplasm of breast
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
MENA(INV) and FN levels were correlated in two breast cancer cohorts, and high levels of MENA(INV) were significantly associated with increased tumor recurrence as well as decreased patient survival.
|
26811325 |
2016 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of genetic variants with colorectal cancer in the extended MENA region: A systematic review.
|
31612830 |
2020 |
|
Malignant neoplasm of stomach
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our research suggests that ENAH might play promoting functions in carcinogenesis and progression of gastric cancer, and may serve as a valuable prognostic marker for primary gastric adenocarcinoma patients.
|
29069803 |
2017 |
|
Malignant neoplasm of stomach
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
PPARγ might inhibit the proliferation and migration of GC cell lines through suppressing the expression of TERT and ENAH.
|
26956036 |
2016 |
|
Malignant neoplasm of stomach
|
0.030 |
Biomarker
|
disease |
BEFREE |
Gastric cancer in young vs old Romanian patients: immunoprofile with emphasis on maspin and mena protein reactivity.
|
25556597 |
2015 |
|
Malignant Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Recent studies show overexpressed ENAH in several cancer types, and ENAH correlates with tumor invasiveness.
|
29069803 |
2017 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
This study aimed to investigate the oncogenic potential of MENA and its capacity to regulate cancer stem cell (CSC)-like phenotypes in HCC cells.
|
28781954 |
2017 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
A typical sequencing study can easily generate hundreds of gigabytes of FASTQ files, while public archives such as ENA and NCBI and large international collaborations such as the Cancer Genome Atlas can accumulate many terabytes of data in this format.
|
24950811 |
2014 |
|
Mammary Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Compared with MENA, higher levels of the prometastatic MENA(INV) isoform associate with α5, which enables 3-D haptotaxis of tumor cells toward the high FN concentrations typically present in perivascular space and in the periphery of breast tumor tissue.
|
26811325 |
2016 |
|
Mammary Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors.
|
23129656 |
2012 |
|
Mammary Neoplasms
|
0.030 |
AlteredExpression
|
group |
LHGDN |
The cytoskeleton regulatory protein hMena (ENAH) is overexpressed in human benign breast lesions with high risk of transformation and human epidermal growth factor receptor-2-positive/hormonal receptor-negative tumors.
|
16533770 |
2006 |
|
Meningococcal Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Further studies of MenB protein vaccines and MenA protein-polysaccharide conjugate vaccines in particular are needed if vaccination in pregnancy is to be utilized as an approach to prevention of meningococcal disease in young infants.
|
29485347 |
2018 |