PRKCE, protein kinase C epsilon, 5581

N. diseases: 112; N. variants: 51
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.500 Biomarker disease CTD_human Expression of protein kinase C isoenzymes in colorectal cancer tissue and their differential activation by different bile acids. 7705931 1995
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.500 GeneticVariation disease UNIPROT
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.310 Therapeutic disease CTD_human Attenuated cardioprotection by ischemic preconditioning in coronary stenosed heart and its restoration by carvedilol. 16782078 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.310 AlteredExpression disease BEFREE We therefore studied platelet PKCε expression from 24 patients with myocardial infarction, 24 patients with stable coronary artery disease and 24 healthy subjects. 23071564 2012
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease 		0.310 Biomarker disease CTD_human Misregulation of membrane trafficking processes in human nonalcoholic steatohepatitis. 29341352 2018
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease 		0.310 AlteredExpression disease BEFREE NAFLD-specific expression and methylation differences were seen for nine genes coding for key enzymes in intermediate metabolism (including PC, ACLY, and PLCG1) and insulin/insulin-like signaling (including IGF1, IGFBP2, and PRKCE) and replicated by bisulfite pyrosequening (independent n = 39). 23931760 2013
CUI: C0002152
Disease: Alloxan Diabetes
Alloxan Diabetes 		0.300 Biomarker disease CTD_human Myocardial effects of ethanol consumption in the rat with streptozotocin-induced diabetes. 12198386 2002
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.300 Biomarker disease CTD_human Myocardial effects of ethanol consumption in the rat with streptozotocin-induced diabetes. 12198386 2002
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.300 Biomarker disease CTD_human Hepatic expression profiling shows involvement of PKC epsilon, DGK eta, Tnfaip, and Rho kinase in type 2 diabetic nephropathy rats. 20665664 2010
CUI: C0017667
Disease: Nodular glomerulosclerosis
Nodular glomerulosclerosis 		0.300 Biomarker disease CTD_human Hepatic expression profiling shows involvement of PKC epsilon, DGK eta, Tnfaip, and Rho kinase in type 2 diabetic nephropathy rats. 20665664 2010
CUI: C0029231
Disease: Organic Mental Disorders, Substance-Induced
Organic Mental Disorders, Substance-Induced 		0.300 Biomarker disease CTD_human Genome wide association for addiction: replicated results and comparisons of two analytic approaches. 20098672 2010
CUI: C0038433
Disease: Streptozotocin Diabetes
Streptozotocin Diabetes 		0.300 Biomarker disease CTD_human Myocardial effects of ethanol consumption in the rat with streptozotocin-induced diabetes. 12198386 2002
CUI: C0038580
Disease: Substance Dependence
Substance Dependence 		0.300 Biomarker disease CTD_human Genome wide association for addiction: replicated results and comparisons of two analytic approaches. 20098672 2010
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		0.300 Biomarker disease CTD_human Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study. 16214533 2005
CUI: C0242231
Disease: Coronary Stenosis
Coronary Stenosis 		0.300 Biomarker disease CTD_human Attenuated cardioprotection by ischemic preconditioning in coronary stenosed heart and its restoration by carvedilol. 16782078 2006
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.300 Biomarker disease CTD_human Multiple genes exhibit phenobarbital-induced constitutive active/androstane receptor-mediated DNA methylation changes during liver tumorigenesis and in liver tumors. 19233941 2009
CUI: C0740858
Disease: Substance abuse problem
Substance abuse problem 		0.300 Biomarker disease CTD_human Genome wide association for addiction: replicated results and comparisons of two analytic approaches. 20098672 2010
CUI: C3241937
Disease: Nonalcoholic Steatohepatitis
Nonalcoholic Steatohepatitis 		0.300 Biomarker disease CTD_human Misregulation of membrane trafficking processes in human nonalcoholic steatohepatitis. 29341352 2018
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.210 Biomarker disease RGD Expression of Protein Kinase C Isoforms in Pancreatic Islets and Liver of Male Goto-Kakizaki Rats, a Model of Type 2 Diabetes. 26398746 2015
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.210 Biomarker disease BEFREE These results identify an expanded set of proteins through which PKCε may drive high-fat diet-induced hepatic insulin resistance that may direct new therapeutic approaches for T2D. 30181290 2018
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.110 AlteredExpression disease BEFREE Indeed, platelets from myocardial infarction patients expressed PKCε with a significant frequency as compared to both stable coronary artery disease and healthy subjects. 23071564 2012
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.110 GeneticVariation disease GWASCAT Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease. 29212778 2018
CUI: C0004096
Disease: Asthma
Asthma 		0.100 GeneticVariation disease GWASCAT Genome-wide association study of leukotriene modifier response in asthma. 26031901 2016
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.020 Biomarker disease BEFREE Taken together, our findings offer the first genetic evidence of the role of PKCε in PCa development and metastasis. 21406403 2011
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.020 Biomarker disease BEFREE Our studies identified a molecular link between PKCε and NF-κB that controls key responses implicated in prostate cancer progression. 22955280 2012