|
Adenocarcinoma of lung (disorder)
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hepatitis C virus (HCV) E2 protein was recently reported to have a double-stranded RNA-activated protein kinase-eukaryotic initiation factor 2alpha (PKR-eIF2alpha) phosphorylation homology domain (PePHD); PKR is induced by interferon (IFN).
|
12818284 |
2003 |
|
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Serum hepatitis C viral (HCV) dynamics, double-stranded RNA-activated protein kinase (PKR) mRNA and MxA mRNA levels in peripheral blood mononuclear cells (PBMC) were analyzed serially in 140 patients who were randomly assigned to a twice daily (3 MU bid) or once daily (6 MU qd) administration group.
|
12927929 |
2003 |
|
Hepatitis B
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Serum hepatitis C viral (HCV) dynamics, double-stranded RNA-activated protein kinase (PKR) mRNA and MxA mRNA levels in peripheral blood mononuclear cells (PBMC) were analyzed serially in 140 patients who were randomly assigned to a twice daily (3 MU bid) or once daily (6 MU qd) administration group.
|
12927929 |
2003 |
|
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hepatitis C and evasion of the interferon system: a PKR paradigm.
|
20006836 |
2009 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
PKR, apoptosis and cancer.
|
10216948 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PKR was partially detected in atypical cells in non-invasive keratinocytic neoplasia but was completely absent from undifferentiated tumor cells of squamous cell carcinoma.
|
12928526 |
2003 |
|
Squamous cell carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
PKR was partially detected in atypical cells in non-invasive keratinocytic neoplasia but was completely absent from undifferentiated tumor cells of squamous cell carcinoma.
|
12928526 |
2003 |
|
nervous system disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
PKR activation is a component of stress-activated pathways that mobilize somatic cell death programs, but its roles in neurological disease largely remain to be defined.
|
13678666 |
2003 |
|
Hepatitis C
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
PKR protein levels were consistently increased in HCV-related HCC compared with NT (p=0.001); similar increases were seen in total eIF2alpha and the PKR inhibitor p58IPK in T compared with NT (p=0.022, p=0.048, respectively).
|
14638359 |
2003 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
LHGDN |
PKR protein levels were consistently increased in HCV-related HCC compared with NT (p=0.001); similar increases were seen in total eIF2alpha and the PKR inhibitor p58IPK in T compared with NT (p=0.022, p=0.048, respectively).
|
14638359 |
2003 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
PKR protein levels were consistently increased in HCV-related HCC compared with NT (p=0.001); similar increases were seen in total eIF2alpha and the PKR inhibitor p58IPK in T compared with NT (p=0.022, p=0.048, respectively).
|
14638359 |
2003 |
|
melanoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
PKR can either be up-regulated through direct induction by the transcription factor E2F-1, or it can be activated through direct protein-protein interactions with the melanoma differentiation-associated gene-7 (MDA7, IL-24).
|
15174900 |
2004 |
|
Hepatitis C, Chronic
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
PKR gene expression and response to pegylated interferon plus ribavirin therapy in chronic hepatitis C.
|
15535414 |
2004 |
|
Hepatitis C, Chronic
|
0.030 |
AlteredExpression
|
disease |
LHGDN |
PKR gene expression and response to pegylated interferon plus ribavirin therapy in chronic hepatitis C.
|
15535414 |
2004 |
|
Glioblastoma Multiforme
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
PKR can be selectively activated in glioblastoma cells by in situ generation of dsRNA following introduction of antisense RNA complementary to an RNA expressed specifically in these cells.
|
16084774 |
2005 |
|
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PKR can be selectively activated in glioblastoma cells by in situ generation of dsRNA following introduction of antisense RNA complementary to an RNA expressed specifically in these cells.
|
16084774 |
2005 |
|
Adult Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PKR can be selectively activated in glioblastoma cells by in situ generation of dsRNA following introduction of antisense RNA complementary to an RNA expressed specifically in these cells.
|
16084774 |
2005 |
|
Childhood Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PKR can be selectively activated in glioblastoma cells by in situ generation of dsRNA following introduction of antisense RNA complementary to an RNA expressed specifically in these cells.
|
16084774 |
2005 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PKR and its signaling pathway are not restricted to a given cell line; therefore, in principle, this dsRNA killing approach can be applied to any cancer that expresses unique RNA sequences.
|
16123598 |
2005 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
PKR and its signaling pathway are not restricted to a given cell line; therefore, in principle, this dsRNA killing approach can be applied to any cancer that expresses unique RNA sequences.
|
16123598 |
2005 |
|
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
Double-stranded RNA-activated protein kinase plays an important role in suppressing HCV replication in an innate state, but may not be essential in IFN therapy.
|
19840259 |
2010 |
|
Cytomegalovirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
PKR-like endoplasmic reticulum kinase is necessary for lipogenic activation during HCMV infection.
|
23592989 |
2013 |
|
Hepatitis C
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Double-stranded RNA-activated protein kinase R (PKR) is known to be upregulated by hepatitis C virus (HCV) and overexpressed in hepatocellular carcinoma (HCC).
|
23844083 |
2013 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Double-stranded RNA-activated protein kinase R (PKR) is known to be upregulated by hepatitis C virus (HCV) and overexpressed in hepatocellular carcinoma (HCC).
|
23844083 |
2013 |