|
Chronic Kidney Diseases
|
0.020 |
GeneticVariation
|
group |
BEFREE |
We have recently reported that a polymorphism (rs734553) in a major urate transporter gene (GLUT9) is a strong predictor of incident renal events in stage 2-5 CKD patients implying that life-time exposure to high uric acid levels may be causally implicated in CKD progression.
|
25435339 |
2015 |
|
Chronic Kidney Diseases
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Known genetic variants in SLC2A9 and ABCG2 were associated with urate and gout in a CKD cohort, with effect sizes for ABCG2 significantly greater in CKD compared to the general population.
|
30181573 |
2018 |
|
Cleft Palate
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although further replication studies are critical to confirming these findings, these results illustrate how genetic associations for nonsyndromic CP can be missed if potential GxE interaction is not taken into account, and this study suggest SLC2A9 and WDR1 should be considered as candidate genes for CP.
|
24516586 |
2014 |
|
Cleft palate, isolated
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although further replication studies are critical to confirming these findings, these results illustrate how genetic associations for nonsyndromic CP can be missed if potential GxE interaction is not taken into account, and this study suggest SLC2A9 and WDR1 should be considered as candidate genes for CP.
|
24516586 |
2014 |
|
Coronary Arteriosclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Associations of the uric acid related genetic variants in SLC2A9 and ABCG2 loci with coronary heart disease risk.
|
25634581 |
2015 |
|
Coronary Arteriosclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study.
|
18398472 |
2008 |
|
Coronary Artery Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
However, a Mendelian randomization approach using the lead SUA-associated SNPs (SLC2A9 and ABCG2) did not support a causal role of elevated SUA levels for premature CAD.
|
30305239 |
2019 |
|
Coronary Artery Disease
|
0.030 |
GeneticVariation
|
disease |
LHGDN |
The aim of the present study was to further elucidate the association of polymorphisms in GLUT9 with gout and coronary artery disease (CAD) or myocardial infarction (MI).
|
18398472 |
2008 |
|
Coronary Artery Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Associations of the uric acid related genetic variants in SLC2A9 and ABCG2 loci with coronary heart disease risk.
|
25634581 |
2015 |
|
Coronary Artery Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to further elucidate the association of polymorphisms in GLUT9 with gout and coronary artery disease (CAD) or myocardial infarction (MI).
|
18398472 |
2008 |
|
Coronary heart disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study.
|
18398472 |
2008 |
|
Coronary heart disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Association analysis between two uric acid related variants (SNP rs11722228 in SLC2A9 and rs4148152 in ABCG2) and CHD risk was performed by logistic regression model.
|
25634581 |
2015 |
|
Creatinine measurement, serum (procedure)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population.
|
29124443 |
2018 |
|
Dementia, familial Danish
|
0.010 |
Biomarker
|
disease |
BEFREE |
Notably, ITM2B variants linked to familial Danish dementia and retinal dystrophy significantly attenuated the inhibition of GLUT9-mediated urate influx.
|
31695625 |
2019 |
|
Diabetes
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Results of the present study suggest that the exon 9 of SLC2A9 gene 109C/T polymorphism is not associated with HUA and diabetes in population living in the coastal area of Shandong province, China.
|
25476142 |
2015 |
|
Diabetes Mellitus
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Five gout susceptibility loci were identified at the genome-wide significance level (p<5.0×10(-8)), which contained well-known urate transporter genes (ABCG2 and SLC2A9) and additional genes: rs1260326 (p=1.9×10(-12); OR=1.36) of GCKR (a gene for glucose and lipid metabolism), rs2188380 (p=1.6×10(-23); OR=1.75) of MYL2-CUX2 (genes associated with cholesterol and diabetes mellitus) and rs4073582 (p=6.4×10(-9); OR=1.66) of CNIH-2 (a gene for regulation of glutamate signalling).
|
25646370 |
2016 |
|
Diabetes Mellitus
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Results of the present study suggest that the exon 9 of SLC2A9 gene 109C/T polymorphism is not associated with HUA and diabetes in population living in the coastal area of Shandong province, China.
|
25476142 |
2015 |
|
Diabetes Mellitus
|
0.030 |
Biomarker
|
group |
BEFREE |
Analysis of correlations between the placental expression of glucose transporters GLUT-1, GLUT-4 and GLUT-9 and selected maternal and fetal parameters in pregnancies complicated by diabetes mellitus.
|
28969476 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Morphometric analysis revealed a significant increase in the expression of GLUT-4 and GLUT-9 in insulin-dependent diabetic women (GDMG2 + PGDM) as compared to both, control and GDMG1 groups (p < .05).
|
27981520 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Our study indicated that the uric acid related alleles of SLC2A9 rs11722228, SLC2A9 rs3775948, ABCG2 rs2231142 might affect DKD susceptibility and possibly through non-uric acid pathway in the Chinese people with type 2 diabetes.
|
26993665 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The SLC2A9 mutation increases the risk for T2DM complicated HUA in Chinese population, which suggested that intron variants between two relatively conserved exons could also be associated with diseases.
|
30087870 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Association of an Exon SNP of SLC2A9 Gene with Hyperuricemia Complicated with Type 2 Diabetes Mellitus in the Chinese Male Han Population.
|
25476142 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.040 |
Biomarker
|
disease |
BEFREE |
More recently, transporters have become important as drug targets (e.g., urate transporter inhibitors as treatment for gout and sodium/glucose cotransporter-2 inhibitors for treating type 2 diabetes).
|
30270426 |
2018 |
|
elevated blood glucose level
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Human metabolic individuality in biomedical and pharmaceutical research.
|
21886157 |
2011 |
|
Endothelial dysfunction
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
These results suggested that the anti-hyperuricaemic and renal protective actions of curcumin might be the result of renal NO-mediated JAK2-STAT3 signalling and TGF-β1 normality, which ameliorated renal endothelial dysfunction to improve renal urate transporter system in this model.
|
23442673 |
2012 |