Lupus Erythematosus, Systemic
|
0.050 |
Biomarker
|
disease |
BEFREE |
Recently, we reported that in SLE T cells, the residual TCR zeta protein is predominantly derived from an alternatively spliced form that undergoes splice deletion of 562 nt (from 672 to 1233 bases) within the 3' untranslated region (UTR) of TCR zeta mRNA.
|
17114503 |
2006 |
Astrocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression of the rPTP beta/zeta protein in oligodendrogliomas and astrocytomas was further validated by immunohistochemistry in an independent set of tumors.
|
18003890 |
2008 |
Carcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Immunoreactivity for both OGF and the zeta receptor were associated with the cytoplasm but not the nucleus in cells of each of these carcinomas.
|
9121309 |
1997 |
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We have demonstrated that primary mouse CD8(+) T lymphocytes expressing the single-chain Fv (scFv)-CD28-zeta receptor have a greater capacity to secrete Tc1 cytokines, induce T-cell proliferation, and inhibit established tumor growth and metastases in vivo.
|
12384413 |
2002 |
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
The expression of the rPTP beta/zeta protein in oligodendrogliomas and astrocytomas was further validated by immunohistochemistry in an independent set of tumors.
|
18003890 |
2008 |
oligodendroglioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression of the rPTP beta/zeta protein in oligodendrogliomas and astrocytomas was further validated by immunohistochemistry in an independent set of tumors.
|
18003890 |
2008 |
Exfoliation Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
On the other hand, increased ubiquitin B mRNA expression followed by significant downregulation of proteasome subunits; 26 S proteasome non-ATPase regulatory subunit 1, and proteasome subunit alpha-type 5 was found in pseudoexfoliation syndrome (PEXS) individuals.
|
30738879 |
2019 |
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results show, for the first time, that PSMA5 promotes the tumorigenic process of PCa and is linked to bortezomib resistance.
|
30807553 |
2019 |
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results show, for the first time, that PSMA5 promotes the tumorigenic process of PCa and is linked to bortezomib resistance.
|
30807553 |
2019 |
Well Differentiated Oligodendroglioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression of the rPTP beta/zeta protein in oligodendrogliomas and astrocytomas was further validated by immunohistochemistry in an independent set of tumors.
|
18003890 |
2008 |
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our observations indicated that LRRC4 may be a negative regulator of the RPTP-zeta receptor, and contribute to suppressing the invasion ability of gliomas cells.
|
16941076 |
2006 |
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
We have demonstrated that primary mouse CD8(+) T lymphocytes expressing the single-chain Fv (scFv)-CD28-zeta receptor have a greater capacity to secrete Tc1 cytokines, induce T-cell proliferation, and inhibit established tumor growth and metastases in vivo.
|
12384413 |
2002 |
Lupus Erythematosus, Systemic
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
It is also shown that in the majority of patients with systemic lupus erythematosus (SLE), who are known to express decreased levels of T cell receptor (TCR) zeta chain and mRNA, the 80-kDa Elf-1 protein does not undergo proper post-transcriptional modification, which results in low levels of the 98-kDa protein, lack of Elf-binding to the TCR zeta promoter, and decreased gene transcription.
|
12727645 |
2003 |
Lupus Erythematosus, Systemic
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Mutations found in six of these patients corresponded to those of the third immunoreceptor tyrosine-based activation motif (ITAM) domain or the GTP/GDP binding site in TCR zetaThus, these mutations in TCR zeta mRNA could be responsible for the decreased expression of the TCR zeta protein in SLE T cells.
|
9802920 |
1998 |
Down Syndrome
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Proteasome zeta chain, an alpha subunit of the 20S proteasome (P < 0.05) and ubiquitin carboxy-terminal hydrolase T (Isopeptidase T), a deubiquitinating enzyme (P < 0.001) were significantly increased in fetal DS compared to controls.
|
11771738 |
2001 |
Malignant neoplasm of kidney
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, only PSMA6 and PSMA5 were not overexpressed in colorectal and kidney cancer, respectively.
|
27966459 |
2017 |
Renal carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, only PSMA6 and PSMA5 were not overexpressed in colorectal and kidney cancer, respectively.
|
27966459 |
2017 |