|
Malignant neoplasm of breast
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Here, we investigate the prognostic significance of CCND1 and EMSY amplification in a large series of breast carcinomas and in BRCA1 and BRCA2 mutation positive breast cancers.
|
19636701 |
2010 |
|
Dermatitis, Atopic
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, the IL1RL1, HLA, IL13 and C11orf30 regions are overlapping susceptibility loci among atopic dermatitis and asthma or allergic rhinitis.
|
23439055 |
2013 |
|
Dermatitis, Atopic
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Variants in a locus near chromosome 11 open reading frame 30 (C11orf30) and leucine-rich repeat containing 32 (LRRC32), which was previously associated with atopic dermatitis and eczema, were also strongly associated with both phenotypes (rs2155219; P(grass) = 9.4 × 10(-9); P(AR) = 3.8 × 10(-8)).
|
22036096 |
2011 |
|
Mammary Neoplasms
|
0.320 |
GeneticVariation
|
group |
BEFREE |
We hypothesized that breast tumors from BRCA2 mutation carriers would be less likely than other familial breast cancers to exhibit EMSY amplification.
|
21327470 |
2011 |
|
Prostate carcinoma
|
0.130 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to screen EMSY for sequence variants and to evaluate its association with the risk of prostate cancer.
|
21064104 |
2011 |
|
Prostate carcinoma
|
0.130 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
|
29892016 |
2018 |
|
Prostate carcinoma
|
0.130 |
GeneticVariation
|
disease |
BEFREE |
Correlated intronic SNPs rs10899221 and rs72944758 formed with other EMSY variants common and rare haplotypes that were associated with increased risk (P=4.0 × 10(-4)) and decreased risk (P=0.01) of PrCa, respectively.
|
23830236 |
2013 |
|
Prostate carcinoma
|
0.130 |
GeneticVariation
|
disease |
BEFREE |
A total of nine non-coding variants on 11q13.5 predispose men to prostate cancer (PrCa). rs200331695 within the EMSY intron is associated with aggressive PrCa and two high linkage disequilibrium (LD) groups of single-nucleotide polymorphisms (SNPs) in the intergenic region are associated with PrCa death.
|
27113481 |
2016 |
|
Asthma
|
0.120 |
GeneticVariation
|
disease |
GWASCAT |
Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.
|
31036433 |
2019 |
|
Asthma
|
0.120 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, the IL1RL1, HLA, IL13 and C11orf30 regions are overlapping susceptibility loci among atopic dermatitis and asthma or allergic rhinitis.
|
23439055 |
2013 |
|
Childhood asthma
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
Variants of C11orf30 were associated with the risk of childhood asthma in the Chinese population.
|
31812328 |
2019 |
|
Childhood asthma
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.
|
31036433 |
2019 |
|
Eosinophilic esophagitis
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
GWAS identifies four novel eosinophilic esophagitis loci.
|
25407941 |
2014 |
|
Eosinophil count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Malignant neoplasm of ovary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We analysed the role of germline EMSY variation in breast/ovarian cancer predisposition.
|
28738860 |
2017 |
|
Malignant neoplasm of ovary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Amplification of the EMSY gene in sporadic breast and ovarian cancers is a poor prognostic indicator.
|
24582497 |
2014 |
|
Malignant neoplasm of ovary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found no association between common genetic variation in EMSY and risk of breast or ovarian cancer in two large study sets of white British women.
|
16029503 |
2005 |
|
Malignant neoplasm of ovary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The EMSY (c11orf30) gene has been proposed as the possible driver of the fourth core of the 11q13 amplicon and its amplification has been associated with breast and ovarian cancers.
|
28824300 |
2017 |
|
Malignant neoplasm of ovary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The remarkable clinical overlap between sporadic EMSY amplification and familial BRCA2 deletion implicates a BRCA2 pathway in sporadic breast and ovarian cancer.
|
14651845 |
2003 |
|
Allergic Reaction
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
|
23817569 |
2013 |
|
Carcinoma, Ovarian Epithelial
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
We analysed the role of germline EMSY variation in breast/ovarian cancer predisposition.
|
28738860 |
2017 |
|
Carcinoma, Ovarian Epithelial
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
The remarkable clinical overlap between sporadic EMSY amplification and familial BRCA2 deletion implicates a BRCA2 pathway in sporadic breast and ovarian cancer.
|
14651845 |
2003 |
|
Carcinoma, Ovarian Epithelial
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
We found no association between common genetic variation in EMSY and risk of breast or ovarian cancer in two large study sets of white British women.
|
16029503 |
2005 |
|
ovarian neoplasm
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
We found no association between common genetic variation in EMSY and risk of breast or ovarian cancer in two large study sets of white British women.
|
16029503 |
2005 |
|
ovarian neoplasm
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
The remarkable clinical overlap between sporadic EMSY amplification and familial BRCA2 deletion implicates a BRCA2 pathway in sporadic breast and ovarian cancer.
|
14651845 |
2003 |