PYY, peptide YY, 5697

N. diseases: 88; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2267227
Disease: Bulimia Nervosa
Bulimia Nervosa 		0.030 Biomarker disease BEFREE <b>Approach:</b> To test the hypothesis that treatment with OLB together with exercise vs. exercise alone would induce feedback action of GH, pancreatic polypeptide (PP), peptide tyrosine tyrosine (PYY), and leptin on ghrelin in Czech women with BN and in healthy-weight Czech women (HW). 30915029 2019
CUI: C0003123
Disease: Anorexia
Anorexia 		0.340 Biomarker disease BEFREE 52 μg/kg) in mice, suggesting the biologic potential of short-length PYY<sub>3-36</sub> analogues with a potent anorectic effect. 30023658 2017
CUI: C0426576
Disease: Gastrointestinal symptom
Gastrointestinal symptom 		0.010 AlteredExpression phenotype BEFREE Gastrointestinal symptoms and circulating levels of peptide YY (PYY) were also measured. 30413932 2019
CUI: C0007095
Disease: Carcinoid Tumor
Carcinoid Tumor 		0.030 Biomarker phenotype BEFREE PYY has been identified in several carcinoid tumors and a decreased expression of PYY may be relevant to the development and progression of colon adenocarcinoma. 11825654 2002
CUI: C0338106
Disease: Adenocarcinoma of colon
Adenocarcinoma of colon 		0.010 AlteredExpression disease BEFREE PYY has been identified in several carcinoid tumors and a decreased expression of PYY may be relevant to the development and progression of colon adenocarcinoma. 11825654 2002
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.010 Biomarker group BEFREE PYY plays a significant role in multiple aspects of cancer from regulation of cell growth to potential therapeutic applications. 11825654 2002
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.010 Biomarker group BEFREE PYY plays a significant role in multiple aspects of cancer from regulation of cell growth to potential therapeutic applications. 11825654 2002
CUI: C0027794
Disease: Neural Tube Defects
Neural Tube Defects 		0.300 Biomarker group CTD_human PYY Y1 receptor antagonist prevented the occurrence of NTD induced not only by PYY but also by vitamin A, a well-known teratogen in humans and animals. 17400914 2007
CUI: C0028754
Disease: Obesity
Obesity 		0.400 Biomarker disease BEFREE PYY, along with few other gut hormones, has been suggested as a potential therapeutic agent for obesity. 18441153 2008
CUI: C0020175
Disease: Hunger
Hunger 		0.100 AlteredExpression phenotype BEFREE Peptide YY (PYY), glucagon-like peptide 1 and ghrelin levels, as well as feelings of hunger and satiety, were determined pre- and postprandially in 62 women and 41 men (age 31+/-14 years; body mass index 25.0+/-3.1 kg/m(2)). 18957934 2008
CUI: C0028754
Disease: Obesity
Obesity 		0.400 Biomarker disease BEFREE PYY and GLP-1 are implicated in regulation of gut motility, food intake and insulin secretion, and are of great interest regarding obesity and type 2 diabetes. 27405092 2017
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.100 Biomarker disease BEFREE PYY and GLP-1 are implicated in regulation of gut motility, food intake and insulin secretion, and are of great interest regarding obesity and type 2 diabetes. 27405092 2017
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis 		0.020 Biomarker disease BEFREE Peptide YY and PP are associated with circulating innate pro-inflammatory cytokines in patients after AP and cumulatively contribute to nearly half of the variance of IL-6, MCP-1, and TNFα. 27918953 2017
CUI: C0028754
Disease: Obesity
Obesity 		0.400 Biomarker disease BEFREE Peptide-YY (PYY) and Glucagon-Like Peptide-1 (GLP-1) play important roles in the regulation of food intake and insulin secretion, and are of translational interest in the field of obesity and diabetes. 29311617 2018
CUI: C0011847
Disease: Diabetes
Diabetes 		0.070 Biomarker disease BEFREE Peptide-YY (PYY) and Glucagon-Like Peptide-1 (GLP-1) play important roles in the regulation of food intake and insulin secretion, and are of translational interest in the field of obesity and diabetes. 29311617 2018
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.070 Biomarker group BEFREE Peptide-YY (PYY) and Glucagon-Like Peptide-1 (GLP-1) play important roles in the regulation of food intake and insulin secretion, and are of translational interest in the field of obesity and diabetes. 29311617 2018
CUI: C0011847
Disease: Diabetes
Diabetes 		0.070 Biomarker disease BEFREE PYY plays a key role in the resolution of diabetes following bariatric surgery in humans. 30639417 2019
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.070 Biomarker group BEFREE PYY plays a key role in the resolution of diabetes following bariatric surgery in humans. 30639417 2019
CUI: C0028754
Disease: Obesity
Obesity 		0.400 Biomarker disease CTD_human A PYY Q62P variant linked to human obesity. 16368708 2006
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.050 Biomarker disease BEFREE A randomized controlled trial of intermittent bolus versus continuous enteral nutrition in healthy humans found that intermittent bolus feeding increased mesenteric arterial blood flow, increased insulin and peptide YY and reduced blood glucose concentration. 29232262 2018
CUI: C0270971
Disease: Floppy infant syndrome
Floppy infant syndrome 		0.010 AlteredExpression disease BEFREE Abnormal plasma ghrelin and PYY levels compared with controls have been reported for subjects with Prader-Willi syndrome (PWS) which is characterized by infantile hypotonia, poor suck reflex and failure to thrive followed by hyperphagia and marked obesity in early childhood. 15754036 2005
CUI: C0015544
Disease: Failure to Thrive
Failure to Thrive 		0.010 AlteredExpression disease BEFREE Abnormal plasma ghrelin and PYY levels compared with controls have been reported for subjects with Prader-Willi syndrome (PWS) which is characterized by infantile hypotonia, poor suck reflex and failure to thrive followed by hyperphagia and marked obesity in early childhood. 15754036 2005
CUI: C2315100
Disease: Pediatric failure to thrive
Pediatric failure to thrive 		0.010 AlteredExpression disease BEFREE Abnormal plasma ghrelin and PYY levels compared with controls have been reported for subjects with Prader-Willi syndrome (PWS) which is characterized by infantile hypotonia, poor suck reflex and failure to thrive followed by hyperphagia and marked obesity in early childhood. 15754036 2005
CUI: C3887638
Disease: Failure to thrive in infant
Failure to thrive in infant 		0.010 AlteredExpression disease BEFREE Abnormal plasma ghrelin and PYY levels compared with controls have been reported for subjects with Prader-Willi syndrome (PWS) which is characterized by infantile hypotonia, poor suck reflex and failure to thrive followed by hyperphagia and marked obesity in early childhood. 15754036 2005
CUI: C0028754
Disease: Obesity
Obesity 		0.400 AlteredExpression disease BEFREE Abnormal plasma ghrelin and PYY levels compared with controls have been reported for subjects with Prader-Willi syndrome (PWS) which is characterized by infantile hypotonia, poor suck reflex and failure to thrive followed by hyperphagia and marked obesity in early childhood. 15754036 2005