Atrial Fibrillation
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PSMB10 expression and trypsin-like activity were increased in atrial tissues and serum from Ang II-treated mice or serum from patients with AF.
|
29507100 |
2018 |
Autoimmune Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Under systemic inflammatory conditions the proteasome subunits LMP2 (beta1i), LMP7 (beta5i), MECL1 (beta2i), and PA28alpha were expressed abundantly at the protein level in the vast majority of systemic autoimmune disorders.
|
16414974 |
2006 |
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
There was a different expression pattern among cancer cell lines for HLA class I heavy chain (HLA-HC), β2 microglobulin, Tapasin, TAP-1, TAP-2, LMP-7 and LMP-10.
|
22134332 |
2012 |
Malignant tumor of cervix
|
0.010 |
Biomarker
|
disease |
BEFREE |
A set of key risk factors anaerococcus, hydrogenophilaceae, eubacterium, PSMB10, KCNIP1 and KRT13 have been identified, which are thought to be involved in the regulation of viral response, cell cycle and epithelial cell differentiation in cervical cancer.
|
29745858 |
2018 |
Crohn Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
High expression of the immunoproteasome subunits beta1i and beta2i is characteristic of the inflamed mucosa of CD.
|
17124531 |
2006 |
Lymphocytic Choriomeningitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Infection with lymphocytic choriomeningitis virus (LCMV) elicited a markedly reduced cytotoxic T cell (CTL) response to the LCMV epitopes GP276-286/Db and NP205-212/Kb in MECL-1-/- mice.
|
16709825 |
2006 |
Multiple Myeloma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MGUS progression correlated directly with calnexin, calreticulin, and tapasin and indirectly with delta, LMP2, and LMP10 expression levels; MM disease status did not correlate with APM levels.
|
20008301 |
2010 |
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
However, LMP-10 showed a significant selective downmodulation in the metastases as well.
|
15547699 |
2004 |
Retinal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Therefore, this study provided novel evidence demonstrating that LMP10 is a positive regulator of NF-kB signaling, which contributes to Ang II-induced retinopathy.
|
29499566 |
2018 |
Vitiligo
|
0.010 |
Biomarker
|
disease |
BEFREE |
No association with vitiligo was found for the MECL1 gene, which encodes a third immunoproteasome subunit and is unlinked to the MHC class II region.
|
14551602 |
2003 |
Hypertensive Retinopathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results showed that immunoproteasome subunit LMP10 expression and its trypsin-like activity were significantly upregulated in the retinas and serum of Ang II-infused mice and in the serum from patients with hypertensive retinopathy.
|
29499566 |
2018 |
Non-arthropod borne lymphocytic choriomeningitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Infection with lymphocytic choriomeningitis virus (LCMV) elicited a markedly reduced cytotoxic T cell (CTL) response to the LCMV epitopes GP276-286/Db and NP205-212/Kb in MECL-1-/- mice.
|
16709825 |
2006 |
Inclusion Body Myositis (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Since the ubiquitin-proteasome system plays a crucial role in non-lysosomal protein degradation, the present study has examined by immunohistochemistry the expression of components of the catalytic core of 20S proteasomes and its regulators: 19S and PA28alpha/beta, and the expression of immunoproteasome subunits LMP2, LMP7, and MECL1 in 8 patients with MM and 10 patients with IBM.
|
15198127 |
2004 |
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
A set of key risk factors anaerococcus, hydrogenophilaceae, eubacterium, PSMB10, KCNIP1 and KRT13 have been identified, which are thought to be involved in the regulation of viral response, cell cycle and epithelial cell differentiation in cervical cancer.
|
29745858 |
2018 |
Inflammatory disorder
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Utilizing these and our previously disclosed low molecular mass polypeptide-2 (LMP2) inhibitor, we demonstrate a requirement of dual LMP7/LMP2 or LMP7/MECL-1 subunit inhibition profiles for potent cytokine expression inhibition and in vivo efficacy in an inflammatory disease model.
|
30380863 |
2018 |
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
There was a different expression pattern among cancer cell lines for HLA class I heavy chain (HLA-HC), β2 microglobulin, Tapasin, TAP-1, TAP-2, LMP-7 and LMP-10.
|
22134332 |
2012 |
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)
|
0.010 |
Biomarker
|
disease |
BEFREE |
No association with vitiligo was found for the MECL1 gene, which encodes a third immunoproteasome subunit and is unlinked to the MHC class II region.
|
14551602 |
2003 |
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
However, LMP-10 showed a significant selective downmodulation in the metastases as well.
|
15547699 |
2004 |
cervical cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
A set of key risk factors anaerococcus, hydrogenophilaceae, eubacterium, PSMB10, KCNIP1 and KRT13 have been identified, which are thought to be involved in the regulation of viral response, cell cycle and epithelial cell differentiation in cervical cancer.
|
29745858 |
2018 |
HIV Infections
|
0.300 |
Biomarker
|
group |
CTD_human |
Host cell gene expression during human immunodeficiency virus type 1 latency and reactivation and effects of targeting genes that are differentially expressed in viral latency.
|
15308739 |
2004 |
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
HIV Coinfection
|
0.300 |
Biomarker
|
disease |
CTD_human |
Host cell gene expression during human immunodeficiency virus type 1 latency and reactivation and effects of targeting genes that are differentially expressed in viral latency.
|
15308739 |
2004 |
Colonic Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Impaired expression of proteasome subunits and human leukocyte antigens class I in human colon cancer cells.
|
12519221 |
2003 |
Low density lipoprotein cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
High density lipoprotein measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |