|
Arthritis, Psoriatic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Using the independent patient and control cohort, we validated the association between ADAMTS9-MAGI1 deletion and PsA risk (p=0.032).
|
25990289 |
2015 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study in Spanish identifies ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9), as a novel asthma susceptibility gene.
|
26620591 |
2016 |
|
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The increase in ADAMTS9 expression can be a useful factor in the prevention of possible metastasis in breast cancer and for the occurrence of a tumor suppressive effect.
|
23690187 |
2013 |
|
Breast Carcinoma
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
In this report, ADAMTS9 expression and methylation was analysed in breast cancer cell lines and tissue samples.
|
29193730 |
2018 |
|
Cancer of Nasopharynx
|
0.010 |
Biomarker
|
disease |
BEFREE |
The metalloprotease ADAMTS9 participates in melanoblast development and is a tumor suppressor in esophageal and nasopharyngeal cancer.
|
20093484 |
2010 |
|
Carcinogenesis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The present study is novel in evaluating the prevalence of ADAMTS9 methylation based on a large number of tumor samples and showing that epigenetic regulation of ADAMTS9 was associated with carcinogenesis.
|
19963134 |
2010 |
|
Carcinoma
|
0.010 |
PosttranslationalModification
|
group |
BEFREE |
ADAMTS9, a member of the metalloprotease large family, has been identified as a candidate 3p14.2 TSG inactivated by aberrant promoter CpG methylation in several carcinomas, but little known about its expression and function in breast cancer.
|
29193730 |
2018 |
|
Chronic central serous chorioretinopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
The SNPs at 3 other AMD loci (CFH, TNFRSF10A, ADAMTS9) showed a trend toward association with typical cCSC.
|
25439433 |
2015 |
|
Ciliopathies
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockdown of adamts9 in zebrafish recapitulated NPHP-RC phenotypes, including renal cysts and hydrocephalus.
|
30609407 |
2019 |
|
Cleft Palate
|
0.010 |
Biomarker
|
disease |
BEFREE |
We provide strong genetic and biochemical evidence that hydrocephaly and white spotting in B3glct mutants resulted from loss of ADAMTS20, eye abnormalities from partial reduction of ADAMTS9, and cleft palate from loss of ADAMTS20 and partially reduced ADAMTS9 function.
|
31600785 |
2019 |
|
Cleft palate, isolated
|
0.010 |
Biomarker
|
disease |
BEFREE |
We provide strong genetic and biochemical evidence that hydrocephaly and white spotting in B3glct mutants resulted from loss of ADAMTS20, eye abnormalities from partial reduction of ADAMTS9, and cleft palate from loss of ADAMTS20 and partially reduced ADAMTS9 function.
|
31600785 |
2019 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We also explored the functions of ADAMTS9 in colorectal cancer cell lines through in vitro experiments.
|
29186710 |
2017 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, little is known about the underlying mechanism of ADAM metallopeptidase with thrombospondin type 1 motif, 9 antisense RNA 2 (ADAMTS9-AS2) in ccRCC.
|
31400752 |
2019 |
|
Corneal Neovascularization
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, when congenic with the C57Bl/6 strain, 80% of ADAMTS9+/- mice developed spontaneous corneal neovascularization. beta-Galactosidase staining enabled by a lacZ cassette targeted to the ADAMTS9 locus showed that capillary endothelial cells (ECs) in embryonic and adult tissues and in capillaries growing into heterotopic tumors expressed ADAMTS9.
|
20093484 |
2010 |
|
Degenerative polyarthritis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
ADAMTS9 gene CA repeat polymorphism may be used to determine the prognosis for OA radiologic progression.
|
27230574 |
2018 |
|
Degenerative polyarthritis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Genes with decreased expression in OA were MMP1, MMP3, and ADAMTS1 (all at P < 0.001), MMP10, TIMP1, and ADAMTS9 (all at P < 0.01), and TIMP4, ADAMTS5, and ADAMTS15 (all at P < 0.05).
|
14730609 |
2004 |
|
Degenerative polyarthritis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Among them, ADAMTS9, FKBP5, and PFKBF3 were identified as valuable methylation-based biomarkers for OA.
|
30317616 |
2019 |
|
Diabetes
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Assuming an additive genetic model the diabetes-associated major C-allele of rs4607103 near ADAMTS9 associated with reduced insulin-stimulated glucose uptake (p = 0.002) during a hyperinsulinemic euglycemic clamp.
|
19789630 |
2009 |
|
Diabetes Mellitus
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Assuming an additive genetic model the diabetes-associated major C-allele of rs4607103 near ADAMTS9 associated with reduced insulin-stimulated glucose uptake (p = 0.002) during a hyperinsulinemic euglycemic clamp.
|
19789630 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.370 |
Biomarker
|
disease |
CTD_human |
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
|
18372903 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.370 |
Biomarker
|
disease |
BEFREE |
Several genetic loci (JAZF1, CDC123/CAMK1D, TSPAN8/LGR5, ADAMTS9, VEGFA and HHEX-IDE) were identified to be significantly related to the risk of type 2 diabetes and quantitative metabolic traits in European populations.
|
20927120 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.370 |
Biomarker
|
disease |
BEFREE |
Our findings contribute to the understanding of the molecular mechanisms underlying insulin resistance and type 2 diabetes and point to inhibition of ADAMTS9 as a potential novel mode of treating insulin resistance.
|
30626608 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Three SNPs in ADAMTS9 were nominally associated with increased risk of T2DM (rs17070905, Odds Ratio (OR) = 2.30, 95% confidence interval (CI) 1.17-4.50; rs17070967, OR = 2.02, 95%CI 1.00-4.06; rs6766801, OR = 2.33, 95%CI 1.18-4.60), but these associations did not reach the statistical significance after adjusting for multiple comparisons.
|
23967108 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.370 |
Biomarker
|
disease |
CTD_human |
Three SNPs in ADAMTS9 were nominally associated with increased risk of T2DM (rs17070905, Odds Ratio (OR) = 2.30, 95% confidence interval (CI) 1.17-4.50; rs17070967, OR = 2.02, 95%CI 1.00-4.06; rs6766801, OR = 2.33, 95%CI 1.18-4.60), but these associations did not reach the statistical significance after adjusting for multiple comparisons.
|
23967108 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
We evaluated the impact on diabetes-related intermediary traits of common novel type 2 diabetes-associated variants in the JAZF1 (rs864745), CDC123/CAMK1D (rs12779790), TSPAN8 (rs7961581), THADA (rs7578597), ADAMTS9 (rs4607103), and NOTCH2 (rs10923931) loci, which were recently identified by meta-analysis of genome-wide association data.
|
18567820 |
2008 |