|
Adult Liver Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Taken together, impaired phosphorylation and ubiquitination by p70S6K and Smurf1 increase the protein stability of TRIB2 in liver cancer and thus may be helpful in the development of diagnosis and treatment strategies against this malignant disease.
|
24089522 |
2013 |
|
Adult Liver Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Moreover, a positive correlation between βTrCP and Smurf1 was also revealed by tissue microarray analysis, indicating that this relationship might be important in liver cancer.
|
28063214 |
2017 |
|
B-Cell Lymphomas
|
0.010 |
AlteredExpression
|
group |
BEFREE |
As a result, we observed higher level of XIST and Smurf1, but lower level of miR-27a in SCI rats and lipopolysaccharide (LPS)-induced primary microglial cells. in vitro, LPS induced SCI microglia cells as described by decreased cell viability and B cell lymphoma 2 (Bcl-2) expression, and increased cell apoptosis rate, Bax and cleaved caspase 3 levels, and tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) secretions. in vivo, a T10 laminectomy caused SCI rats as evidenced by decreased Basso-Beattie-Bresnahan Locomotor Rating Scale (BBB) score and induced expression of Bax, cleaved caspase 3, TNF-α and IL-6.
|
31778769 |
2020 |
|
Bone Diseases
|
0.020 |
AlteredExpression
|
group |
BEFREE |
These findings provide a novel strategy through targeting Smurf1 ligase activity to potentially treat bone disorders such as osteoporosis.
|
28881580 |
2017 |
|
Bone Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Our findings first establish a link between p97 and Smurf1, providing an in-depth understanding of how Smurf1 is regulated, as well as the mechanism of p97-related bone diseases.-Li, H., Cui, Y., Wei, J., Liu, C., Chen, Y., Cui, C.-P., Li, L., Zhang, X., Zhang, L. VCP/p97 increases BMP signaling by accelerating ubiquitin ligase Smurf1 degradation.
|
30335548 |
2019 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Our study reveals a novel positive feedback between SMURF1 and ER alpha signaling in supporting breast cancer growth.
|
29433542 |
2018 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
These results suggest that EGFinduced SMURF1 plays a role in breast cancer cell migration and invasion through the downregulation of RhoA.
|
24241683 |
2013 |
|
Breast Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Knockdown of Smurf2 in human breast cancer MDA-MB-231 cells resulted in increases in the levels of Smurf1 protein, and enhancement of cell migration in vitro and bone metastasis in vivo.
|
18927080 |
2008 |
|
Breast Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
USF2 inhibits the transcriptional activity of Smurf1 and Smurf2 to promote breast cancer tumorigenesis.
|
30244169 |
2019 |
|
Breast Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Finally, we provide scattered clues of regulation of SMURF2 by oncogenic miRNAs, specifically considering longstanding questions related to regulation of SMURF1 and WWPs by miRNAs in BCa.
|
31456194 |
2019 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
The HECT-type ubiquitin ligase Smurf1 (Smad ubiquitination regulatory factor-1) plays the prominent role in regulation of bone formation, embryonic development, and tumorigenesis by directing the ubiquitin-proteasomal degradation of specific targets.
|
28881580 |
2017 |
|
Carcinogenesis
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis.
|
24821572 |
2014 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Thus, we propose that the PKA-Smurf1-PIPKIγ pathway has an important role in pulmonary tumorigenesis and imposes substantial clinical impact on development of novel diagnostic markers and therapeutic targets for lung cancer treatment.
|
28581524 |
2017 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Using this method, we screened for small-molecule modulators of SMAD ubiquitin regulatory factor 1 (SMURF1), which belongs to the NEDD4 family of E3 ubiquitin ligases and is an attractive therapeutic target because of its roles in tumorigenesis.
|
30587574 |
2019 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Smad ubiquitylation regulatory factor 1 (Smurf1) has been identified to play a critical role in bone homeostasis, development, cell cycle regulation and tumorigenesis.
|
29550577 |
2018 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Smurf1 controls S phase progression and tumorigenesis through Wee1 degradation.
|
28294307 |
2017 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
RASSF1A Directly Antagonizes RhoA Activity through the Assembly of a Smurf1-Mediated Destruction Complex to Suppress Tumorigenesis.
|
26825171 |
2016 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Together with its closely related homolog Smurf1, Smurf2 was initially recognized as a negative regulator of transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) signaling, but subsequent studies have expanded its function to regulate many different signaling pathways and play important roles in genomic stability, cell polarity, tissue homeostasis and carcinogenesis.
|
29805305 |
2018 |
|
Carcinoma of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Here we show that the homologous to E6AP carboxyl terminus (HECT)-type ubiquitin ligase Smad ubiquitination regulatory factor 1 (Smurf1) interacts with and targets KLF2 for poly-ubiquitination and proteasomal degradation specifically in lung cancer H1299 cells.
|
21382345 |
2011 |
|
Carcinoma of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Moreover, PKA-Smurf1-PIPKIγ signal transduction takes a significant part in lung cancer cell growth and in vivo tumorigenesis.
|
28581524 |
2017 |
|
Carcinoma, Ovarian Epithelial
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The inhibition of SMURF1 expression may be a promising strategy for the treatment of patients with OC.
|
30542716 |
2019 |
|
Carcinoma, Ovarian Epithelial
|
0.020 |
Biomarker
|
disease |
BEFREE |
Taken all data together, these findings demonstrated that the absence of SMURF1 repressed cell proliferation, invasive capability, and EMT process in ovarian cancer through DAB2IP/AKT/Skp2 signaling loops, suggesting that SMURF1 may serve as a new potential therapeutic agent for ovarian cancer.
|
30672020 |
2019 |
|
Cocaine Abuse
|
0.300 |
Biomarker
|
disease |
CTD_human |
E3 Ubiquitin-Protein Ligase SMURF1 in the Nucleus Accumbens Mediates Cocaine Seeking.
|
30158054 |
2018 |
|
Cocaine Dependence
|
0.300 |
Biomarker
|
disease |
CTD_human |
E3 Ubiquitin-Protein Ligase SMURF1 in the Nucleus Accumbens Mediates Cocaine Seeking.
|
30158054 |
2018 |
|
Cocaine-Related Disorders
|
0.300 |
Biomarker
|
group |
CTD_human |
E3 Ubiquitin-Protein Ligase SMURF1 in the Nucleus Accumbens Mediates Cocaine Seeking.
|
30158054 |
2018 |