BAD, BCL2 associated agonist of cell death, 572

N. diseases: 125; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.320 Biomarker disease CTD_human Combination of proliferative and apoptotic properties prompts prostate cancer cells to be "addicted" to increased levels of phosphorylated BAD. 19593445 2009
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.320 PosttranslationalModification disease BEFREE Using pharmacological inhibitors and dominant-negative proteins, we showed that VIP-induced cytoprotection and BAD phosphorylation are mediated via both Ras/MAPK and PKA pathways in CSCs of prostate cancer LNCaP and C4-2 cells, but only PKA signaling was involved in CSCs of DUVIPR (DU145 prostate cancer cells ectopically expressing VIP receptor) and breast cancer MCF7 cells. 28569785 2017
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.320 Biomarker disease CTD_human Bad expression influences time to androgen escape in prostate cancer. 17542986 2007
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.320 AlteredExpression disease BEFREE Combination of proliferative and apoptotic properties prompts prostate cancer cells to be "addicted" to increased levels of phosphorylated BAD. 19593445 2009
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack 		0.300 Biomarker disease CTD_human Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway. 12629175 2003
CUI: C0023418
Disease: leukemia
leukemia 		0.300 Biomarker disease CTD_human A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells. 12970779 2003
CUI: C0472381
Disease: Posterior Circulation Transient Ischemic Attack
Posterior Circulation Transient Ischemic Attack 		0.300 Biomarker disease CTD_human Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway. 12629175 2003
CUI: C0751019
Disease: Carotid Circulation Transient Ischemic Attack
Carotid Circulation Transient Ischemic Attack 		0.300 Biomarker disease CTD_human Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway. 12629175 2003
CUI: C0751020
Disease: Transient Ischemic Attack, Vertebrobasilar Circulation
Transient Ischemic Attack, Vertebrobasilar Circulation 		0.300 Biomarker disease CTD_human Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway. 12629175 2003
CUI: C0751021
Disease: Crescendo Transient Ischemic Attacks
Crescendo Transient Ischemic Attacks 		0.300 Biomarker disease CTD_human Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway. 12629175 2003
CUI: C0751022
Disease: Brain Stem Ischemia, Transient
Brain Stem Ischemia, Transient 		0.300 Biomarker disease CTD_human Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway. 12629175 2003
CUI: C0917805
Disease: Transient Cerebral Ischemia
Transient Cerebral Ischemia 		0.300 Biomarker disease CTD_human Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway. 12629175 2003
CUI: C1527335
Disease: Transient Ischemic Attack, Anterior Circulation
Transient Ischemic Attack, Anterior Circulation 		0.300 Biomarker disease CTD_human Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway. 12629175 2003
CUI: C0017638
Disease: Glioma
Glioma 		0.240 Biomarker disease BEFREE Thus, our data suggest that glioma cell survival occurs through a novel PI (3)-kinase/PDK1/PKC-ι/BAD mediated pathway. 21419810 2011
CUI: C0017638
Disease: Glioma
Glioma 		0.240 Biomarker disease RGD pERK, pAkt and pBad: a possible role in cell proliferation and sustained cellular survival during tumorigenesis and tumor progression in ENU induced transplacental glioma rat model. 16944316 2006
CUI: C0017638
Disease: Glioma
Glioma 		0.240 Biomarker disease BEFREE Surprisingly, although siRNA-mediated depletion of BAD in glioma cells abrogates cytotoxic- and chemotherapy-induced apoptosis, TWEAK still displays a strong protective effect, suggesting that BAD serine 136 phosphorylation plays a minor role in TWEAK-Akt2-induced glioma cell survival. 19861406 2009
CUI: C0017638
Disease: Glioma
Glioma 		0.240 AlteredExpression disease BEFREE The apoptotic death in the glioma cell lines treated with PPARgamma agonists was correlated with the transient up-regulation of Bax and Bad protein levels. 12065618 2002
CUI: C0017638
Disease: Glioma
Glioma 		0.240 Biomarker disease BEFREE Inhibition of either PPARgamma or MEK1/2 blocked the Troglitazone-mediated phosphorylation of BAD and further increased the synergistic induction of glioma cell death by TRAIL and Troglitazone. 19158480 2008
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.220 Therapeutic disease RGD High energy shock waves and 5-aminolevulinic for sonodynamic therapy: effects in a syngeneic model of colon cancer. 21214291 2011
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.220 GeneticVariation disease BEFREE Using principal component analysis to derive a numeric score representing pathway expression, we evaluated clinico-genomic datasets (n=427) from corresponding normal, pre-invasive and invasive cancers of different types, such as ovarian, endometrial, breast and colon cancers in order to determine the associations between the BAD-mediated apoptotic pathway and cancer development. 25653146 2015
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.220 GeneticVariation disease BEFREE This is the first report on Bad gene mutation in human malignancies, and our data suggest that Bad gene is occasionally mutated in colon cancers and that somatic mutation of Bad may contribute to the development of colon cancers. 15033904 2004
CUI: C0028754
Disease: Obesity
Obesity 		0.210 GeneticVariation disease BEFREE Common BAD and SERPINA6 variants were associated (p<0.05) with obesity and insulin resistance, respectively. 29126409 2017
CUI: C0028754
Disease: Obesity
Obesity 		0.210 Biomarker disease RGD More activated cardiac mitochondrial-dependent apoptotic pathway in obese Zucker rats. 18070754 2007
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia 		0.200 Biomarker disease RGD Melatonin attenuates the focal cerebral ischemic injury by inhibiting the dissociation of pBad from 14-3-3. 18078455 2008
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia 		0.200 Biomarker disease RGD Cluster analysis of mRNA expression levels identifies multiple sequential patterns following focal cerebral ischemia. 22843461 2012