Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
With Multicycle, in addition to debris and aggregate determination, an index that included background, aggregates and debris (%BAD) occurring between the boundaries of the tumor G1 and G2 region was evaluated.
|
7817950 |
1995 |
Uveal melanoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Bilateral primary uveal melanoma. Bad luck or bad genes?
|
8594511 |
1996 |
Prostatic Neoplasms
|
0.350 |
PosttranslationalModification
|
group |
LHGDN |
Protein kinase A RIalpha antisense inhibition of PC3M prostate cancer cell growth: Bcl-2 hyperphosphorylation, Bax up-regulation, and Bad-hypophosphorylation.
|
11839683 |
2002 |
Glioma
|
0.240 |
AlteredExpression
|
disease |
BEFREE |
The apoptotic death in the glioma cell lines treated with PPARgamma agonists was correlated with the transient up-regulation of Bax and Bad protein levels.
|
12065618 |
2002 |
ovarian neoplasm
|
0.020 |
PosttranslationalModification
|
disease |
LHGDN |
Our findings suggest that paclitaxel induces the phosphorylation of BAD Ser-112 via the ERK cascade, and the phosphorylation of both BAD Ser-136 and Raf-1 Ser-259 via the PI-3K-Akt cascade, and that inhibition of either of these cascades sensitizes ovarian cancer cells to paclitaxel.
|
12087097 |
2002 |
Heart failure
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Consistent with a role for apoptosis in heart failure, we also observed a significant decrease in phosphorylation of BAD at Ser-112.
|
12388275 |
2003 |
Congestive heart failure
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Consistent with a role for apoptosis in heart failure, we also observed a significant decrease in phosphorylation of BAD at Ser-112.
|
12388275 |
2003 |
Transient Ischemic Attack
|
0.300 |
Biomarker
|
disease |
CTD_human |
Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway.
|
12629175 |
2003 |
Posterior Circulation Transient Ischemic Attack
|
0.300 |
Biomarker
|
disease |
CTD_human |
Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway.
|
12629175 |
2003 |
Carotid Circulation Transient Ischemic Attack
|
0.300 |
Biomarker
|
disease |
CTD_human |
Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway.
|
12629175 |
2003 |
Transient Ischemic Attack, Vertebrobasilar Circulation
|
0.300 |
Biomarker
|
disease |
CTD_human |
Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway.
|
12629175 |
2003 |
Crescendo Transient Ischemic Attacks
|
0.300 |
Biomarker
|
disease |
CTD_human |
Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway.
|
12629175 |
2003 |
Brain Stem Ischemia, Transient
|
0.300 |
Biomarker
|
disease |
CTD_human |
Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway.
|
12629175 |
2003 |
Transient Cerebral Ischemia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway.
|
12629175 |
2003 |
Transient Ischemic Attack, Anterior Circulation
|
0.300 |
Biomarker
|
disease |
CTD_human |
Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway.
|
12629175 |
2003 |
leukemia
|
0.300 |
Biomarker
|
disease |
CTD_human |
A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells.
|
12970779 |
2003 |
Malignant tumor of colon
|
0.220 |
GeneticVariation
|
disease |
BEFREE |
This is the first report on Bad gene mutation in human malignancies, and our data suggest that Bad gene is occasionally mutated in colon cancers and that somatic mutation of Bad may contribute to the development of colon cancers.
|
15033904 |
2004 |
Malignant Neoplasms
|
0.080 |
GeneticVariation
|
group |
BEFREE |
This is the first report on Bad gene mutation in human malignancies, and our data suggest that Bad gene is occasionally mutated in colon cancers and that somatic mutation of Bad may contribute to the development of colon cancers.
|
15033904 |
2004 |
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Co-immunoprecipitation assay revealed that binding of one of the tumor-derived Bad mutants with Bcl-2 and Bcl-XL is reduced.
|
15033904 |
2004 |
Colonic Neoplasms
|
0.030 |
GeneticVariation
|
group |
LHGDN |
Inactivating mutations of proapoptotic Bad gene in human colon cancers.
|
15033904 |
2004 |
Adenocarcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
To explore the possibility that the genetic alterations of Bad might be involved in the development of human cancers, we analyzed the entire coding region and all splice sites of human Bad gene in 47 colon adenocarcinomas.
|
15033904 |
2004 |
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In this study, the expression of phosphorylated Akt at Thr308 and Ser473, BCL-2-antagonist of cell death (BAD) at Ser136 and glycogen synthase kinase-3beta (GSK-3beta) at Ser9 in 47 paraffin-embedded human colorectal carcinoma (CRC) tissues were determined by immunohistochemical staining in order to dissect the alterations in the signal transduction pathways in CRC.
|
15183529 |
2004 |
Myocardial Reperfusion Injury
|
0.200 |
Biomarker
|
phenotype |
RGD |
Protein kinase Cdelta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria.
|
15339931 |
2004 |
Shock, Hemorrhagic
|
0.200 |
Biomarker
|
phenotype |
RGD |
D-lactate increases pulmonary apoptosis by restricting phosphorylation of bad and eNOS in a rat model of hemorrhagic shock.
|
15345971 |
2004 |
Infection
|
0.010 |
Biomarker
|
group |
LHGDN |
Broad degradation of proapoptotic proteins with the conserved Bcl-2 homology domain 3 during infection with Chlamydia trachomatis.
|
15731037 |
2005 |