|
Hyperparathyroidism, Primary
|
0.200 |
Biomarker
|
disease |
BEFREE |
Primary hyperparathyroidism is excluded by the immunoradiometric assay for parathyroid hormone, which is suppressed.
|
8060769 |
1994 |
|
Hyperparathyroidism, Primary
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The present study is the first to indicate that the polymorphism of PTH/PTHrP receptor gene is closely related to the extent of bone mass reduction in pHPT and that this polymorphism would be one of the genetic factors responsible for the severity of the pathological state of pHPT.
|
11014383 |
2000 |
|
Hyperparathyroidism, Primary
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Individuals with PHPT and nephrolithiasis frequently have elevated baseline PTH and calcium levels.
|
29124877 |
2018 |
|
Hyperparathyroidism, Primary
|
0.200 |
Biomarker
|
disease |
BEFREE |
We suggest that sustained stimulation of PTH receptors present in brain, muscle, and hematopoietic cells have to be considered as one independent, important cause of molecular disease in PHPT leading to profound alterations in gene expression that may help explain symptoms like muscle fatigue, cardiovascular pathology, and precipitation of psychiatric illness.
|
17227961 |
2007 |
|
Hyperparathyroidism, Primary
|
0.200 |
Biomarker
|
disease |
BEFREE |
Only in pHPT was a negative correlation of borderline significance between serum parathormone (PTH) and number of aberrated chromosomes noticed (tau=-0.258, p=0.07).
|
17514620 |
2007 |
|
Hyperparathyroidism, Primary
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Primary hyperparathyroidism (HPT), most commonly due to parathyroid adenoma, is a disorder characterized by excessive secretion of PTH.
|
10704427 |
2000 |
|
Hyperparathyroidism, Primary
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study was designed to evaluate the results of a series of patients with PHPT who underwent minimally invasive radioguided parathyroidectomy (MIRP) using very low dose (1 mCi) of TC-99m sestamibi (MIBI) without application of intraoperative parathyroid hormone (PTH) assay or frozen section analysis.
|
28192245 |
2017 |
|
Hyperparathyroidism, Primary
|
0.200 |
Biomarker
|
disease |
BEFREE |
Primary hyperparathyroidism (PHPT) is characterised by increased production of parathyroid hormone (PTH) resulting in elevated serum calcium levels.
|
21698093 |
2011 |
|
Hyperparathyroidism, Primary
|
0.200 |
Biomarker
|
disease |
BEFREE |
The set point for parathyroid hormone (PTH) secretion is increased in patients with primary hyperparathyroidism, possibly because of receptor defect(s).
|
9854589 |
1998 |
|
Hyperparathyroidism, Primary
|
0.200 |
Biomarker
|
disease |
BEFREE |
Primary hyperparathyroidism (pHPT) is a common endocrine disease characterized by excessive secretion of parathyroid hormone and an increased level of serum calcium.
|
27071708 |
2016 |
|
Hyperparathyroidism, Primary
|
0.200 |
Biomarker
|
disease |
BEFREE |
Primary hyperparathyroidism is commonly caused by excess production of parathyroid hormone from sporadic parathyroid adenomas.
|
29982334 |
2018 |
|
Hyperparathyroidism, Primary
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Cure rate was 88% in the normal PTH group, compared to 96% in classic PHPT (p = 0.02).
|
29134314 |
2018 |
|
Hyperparathyroidism, Primary
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this short pilot investigation, 1 week of maximally titrated ACEi did not impact PTH in participants without P-HPT, but resulted in a modest and marginally significant reduction of PTH but not calcium, among participants with P-HPT.
|
28808443 |
2017 |
|
Hyperparathyroidism, Primary
|
0.200 |
Biomarker
|
disease |
BEFREE |
Thus, we studied 29 patients with FBH from 11 families, 29 age- and sex-matched controls, and 42 patients with primary hyperparathyroidism (1 degree HPT), measuring PTH with a highly sensitive two-site immunochemiluminometric assay and the hypercalcemic tumor factor PTH-related peptide (PTHrP) with an extraction/concentration RIA.
|
1997510 |
1991 |
|
Hyperparathyroidism, Primary
|
0.200 |
Biomarker
|
disease |
BEFREE |
Primary hyperparathyroidism (PHPT) is a common endocrine disorder, resulting from the autonomous production of parathyroid hormone from 1 or more abnormal parathyroid glands.
|
31255197 |
2019 |
|
Hyperparathyroidism, Primary
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Additional HPT diagnosis is acknowledged by serum ionized calcium and parathormone levels.
|
24969991 |
2014 |
|
Hyperparathyroidism, Primary
|
0.200 |
Biomarker
|
disease |
BEFREE |
Original articles reporting complications and diagnostic performance of FNA-PTH in biochemically and histopathologically diagnosed PHPT were selected.
|
31311003 |
2019 |
|
Hyperparathyroidism, Primary
|
0.200 |
Biomarker
|
disease |
BEFREE |
Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterised by hypercalcaemia and parathormone increase.
|
30459009 |
2020 |
|
Hyperparathyroidism, Primary
|
0.200 |
Biomarker
|
disease |
BEFREE |
Recently, another variant of PHPT (normocalcaemic PHPT) has been described in which the serum calcium is normal but the serum PTH is elevated, in the absence of any secondary cause for PTH elevation.
|
15606372 |
2005 |
|
Hyperparathyroidism, Primary
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
We assessed if cerebrovascular function is impaired in PHPT, improves post-parathyroidectomy and is associated with PTH level and cognitive dysfunction.
|
31621051 |
2020 |
|
Hyperparathyroidism, Primary
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Mean calcium-induced decreases of intact and bioPTH were indistinguishable from normal in FBH, but PTH levels generally remained elevated at 5 minutes in primary HPT.
|
2028833 |
1991 |
|
Hyperparathyroidism, Primary
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, combination Cl/PO4 with ALP might be a low-cost, simple, available predictive marker of PHPT in Chinese individuals, particularly Chinese remote region where the method used to measure PTH cannot be done.
|
28687737 |
2017 |
|
Hyperparathyroidism, Primary
|
0.200 |
Biomarker
|
disease |
BEFREE |
The primary cause of PHPT is a benign overgrowth of parathyroid tissue causing excessive secretion of parathyroid hormone.
|
30979723 |
2019 |
|
Hyperparathyroidism, Primary
|
0.200 |
Biomarker
|
disease |
BEFREE |
When administered intermittently, PTH increases bone mass, but when present continuously and in excess (e.g.PHPT), bone loss ensues.
|
29049872 |
2018 |
|
Hyperparathyroidism, Primary
|
0.200 |
Biomarker
|
disease |
BEFREE |
The increasing use of serum PTH assay in the set of the diagnostic workout in patients with osteoporosis has identified patients with features of surgically confirmed primary hyperparathyroidism (PHPT) associated with persistent normal serum calcium levels, which has been recognized as a distinct entity from hypercalcemic PHPT (HPHPT) by the last international consensus.
|
30641527 |
2019 |