|
Endometriosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Cyclooxygenase-2 ( COX -2) gene-765G/C polymorphism and advanced-stage endometriosis in Korean women.
|
22587873 |
2012 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
LHGDN |
Cyclooxygenase-2 and VEGF were closely correlated with each other, and both of them appear to play a role in the angiogenesis of ovarian endometriosis.
|
18053993 |
2008 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The amount of indoleamine 2,3-dioxygenase-1 (IDO1) and cyclooxygenase-2 (COX-2) in E-MenSCs co-cultured with allogenic peripheral blood mononuclear cells (PBMCs) was shown to be higher both at the gene and protein levels, and higher IDO1 activity was detected in the endometriosis group.
|
24939730 |
2014 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
CTD_human |
Higher expression of PLA2G2A, PTGS2, AKR1B1, AKR1C3 and ABCC4 was seen in 22-B endometriosis cells compared to HIESC control cells.
|
25446850 |
2015 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The GnRH agonist reduced aromatase P450 and COX-2 by direct action on the eutopic endometrium of patients with endometriosis and ovarian endometrioma.
|
19401614 |
2009 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
By contrast, the cyclic stretch mimicking physiological peristalsis (3% elongation at 2 cycles/min) did not induce significant COX-2, mPGES-1 or PGE(2) production within 12 h. Both COX-2 and mPEGS-1 are PGE(2) synthases, and the aberrant COX-2 and PGE(2) production play important roles in the pathogenesis of endometriosis.
|
23239446 |
2012 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we identified ursolic acid (UA) as a natural inhibitor of COX-2 and investigated its effects on endometriosis progression.
|
31527378 |
2020 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In the endometriotic lesions, prostaglandin E2 (PGE2) produced by cyclooxygenase-2 (COX-2), binds to its EP4 receptor (EP4), and via c-Src kinase induces MMPs activation, promoting endometriosis.
|
27038655 |
2016 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
LHGDN |
In patients with severe endometriosis who underwent fertility-sparing complete ablation, COX-2 overexpression characterizes a subgroup of patients with lower risk of relapse and longer relapse-free survival.
|
15979990 |
2005 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The elevation of IL-18 in the peritoneal fluid of endometriosis patients and the induction of COX-II in peritoneal monocytes by IL-18 suggest that IL-18 plays a pathogenic role in endometriosis.
|
14998974 |
2004 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Case-control study to investigate the association between endometriosis and four inflammation-related genes: interleukin (IL)-6, IL-10, IL-1 beta, and cyclooxygenase-2.
|
18930197 |
2009 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Overall, the results of the study reveal the efficacy of 6-shogaol against endometriosis via effectively suppressing proliferation of the lesions and modulating angiogenesis and COX-2/NF-κB-mediated inflammatory cascades.
|
30402023 |
2018 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
These findings indicate that Cox-2 may be involved in the pathogenesis and progression of endometriosis.
|
20068324 |
2010 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
RGD |
A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat model.
|
20056215 |
2010 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Herein, we report that macrophage migration inhibitory factor (MIF), a potent proinflammatory and growth-promoting factor found at elevated concentrations in the peritoneal fluid of women with endometriosis and active endometriosis lesions, acts directly on ectopic endometrial cells to stimulate the synthesis of COX-2, the inducible form of COX, and the release of PGE(2).
|
19299454 |
2009 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
LHGDN |
Interleukin (IL)-17A stimulates IL-8 secretion, cyclooxygensase-2 expression, and cell proliferation of endometriotic stromal cells.
|
18079209 |
2008 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The prevalence and immunohistologic study (Ki-67, BAF250a, COX-2) of cases of cellular and architectural atypia in endometriosis were analyzed.
|
31074246 |
2019 |
|
Endometriosis
|
0.600 |
Therapeutic
|
disease |
RGD |
[Effect of letrozole on endometrosis and apoptosis of ectopic endometrial cells in rats].
|
23406865 |
2013 |
|
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Additionally, endometriotic stromal cells (ESCs; n = 3) from ectopic endometriosis lesions were cultured and incubated with/without NGF and/or Trk inhibitor K252a, followed by expression analysis of prostaglandin-endoperoxide synthase 2 (PTGS-2)/cyclooxygenase 2 (COX-2; reverse transcription quantitative real-time polymerase chain reaction and Western blot) and prostaglandin E2 (PGE2) secretion (enzyme-linked immunosorbent assay).
|
28673205 |
2018 |
|
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
COX-2 mRNA level in unmethylated endometrium of the endometriosis group or the control group was 2.39-fold and 2.66-fold, respectively, higher than that in the methylated endometrium of the same group (P < 0.01).
|
22608095 |
2012 |
|
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Because overexpression of COX-2 has been demonstrated to be a master regulator in endometriosis progression, our data demonstrate the critical function of proinflammatory cytokines and the COUP-TFII regulatory gene network in the progression of endometriosis.
|
24423359 |
2014 |
|
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
PGE(2) production in endometriosis is up-regulated by increased levels of the enzyme cyclo-oxygenase-2 (COX-2) in this tissue.
|
16123052 |
2006 |
|
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Comparatively, expression of COX-2 protein is higher in eutopic endometria from women with endometriosis compared with women without endometriosis.
|
18039779 |
2008 |
|
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that the SHP and CDX1 expression increased by hypoxia play an active role in inducing inflammatory COX-2 expression in the pathogenesis of endometriosis.
|
21613300 |
2011 |
|
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
For the first time, decreased expression of PTGS2 was found in cumulus cells of infertile women with endometriosis compared with controls (7.2 ± 10.5 versus 12.4 ± 15.7), which might be related to reduced levels of COX-2 in the cumulus cells of women with the disease.
|
28734688 |
2017 |