PTHLH, parathyroid hormone like hormone, 5744

N. diseases: 321; N. variants: 5
Disease: Breast Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 AlteredExpression disease BEFREE In the breast cancer cell line MCF-7, PTHrP overexpression is associated with increased mitogenesis. 11796515 2002
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 AlteredExpression disease BEFREE Once formed, Smad2/3:Gli2 complexes stimulate the expression of parathyroid hormone-related protein necessary for breast cancer metastasis to bone. 26160166 2015
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 AlteredExpression disease BEFREE Parathyroid hormone-related protein (PTHrP) expression in breast cancer is enriched in bone metastases compared to primary tumors. 29867773 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 AlteredExpression disease BEFREE Amphiregulin-EGFR signaling regulates PTHrP gene expression in breast cancer cells. 17882547 2008
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 AlteredExpression disease BEFREE PTHrP plays a central role in humoral hypercalcemia, and its expression has been reported to be closely associated with bone metastasis of breast carcinoma. 23588777 2013
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 AlteredExpression disease BEFREE Because the stromal component of the breast produces factors implicated in proliferation and differentiation of mammary epithelial tissue and tumors, the aim of this study was to investigate the PTHrP expression by mammary fibroblasts from breast cancer tumors and normal breast. 12549623 2002
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 AlteredExpression disease BEFREE The gene expression signature associated with loss of PTHrP expression in vivo correlated with poorer outcome in human breast cancer. 19723659 2009
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 AlteredExpression disease BEFREE PTHrP inhibits BMP-6 expression through the PKA signaling pathway in breast cancer cells. 20401668 2011
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 AlteredExpression disease BEFREE Coexpression of parathyroid hormone related protein and its receptor in early breast cancer predicts poor patient survival. 12374685 2002
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 AlteredExpression disease BEFREE Integrated molecular analysis of both the EO771/EO771.LMB and 67NR/4T1.2 pairs indicated that upregulation of matrix metalloproteinase-3 (MMP-3), parathyroid hormone-like hormone (Pthlh) and S100 calcium binding protein A8 (S100a8) and downregulation of the thrombospondin receptor (Cd36) might be causally involved in metastatic dissemination of breast cancer. 25633981 2015