Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
A proprotein convertase/MMP-14 proteolytic cascade releases a novel 40 kDa vasculostatin from tumor suppressor BAI1.
|
22330140 |
2012 |
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Immunohistochemical analysis of tumour samples confirmed a reduction in the microvessel density index in brain-specific angiogenesis inhibitor 1-overexpressing tumours.
|
11875720 |
2002 |
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Although BAI1 was named for the ability of its extracellular region to inhibit angiogenesis in tumor models, its function in physiological contexts was elusive and remained an orphan receptor until recently.
|
21618836 |
2010 |
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Knockout of Adgrb1 in mice augments proliferation of cerebellar granule neuron precursors, and leads to accelerated tumor growth in the Ptch1<sup>+/-</sup> transgenic MB mouse model.
|
29894688 |
2018 |
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
In conclusion, BAI-1 is suggested to be a potential novel therapautic target for the inhibition of tumor neovascularization.
|
27356780 |
2016 |
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
In particular, recent findings suggest emerging roles for BAI1 in the regulation of phenomena including phagocytosis, synaptogenesis, and the inhibition of tumor growth and angiogenesis via the processing of its extracellular domain into secreted vasculostatins.
|
21509575 |
2011 |
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
The aim of the present study was to investigate the expression levels of brain‑specific angiogenesis inhibitor‑1 (BAI‑1) in bladder transitional cell carcinoma (BTCC) at different stages and the mechanism by which it inhibits tumor endothelial cell proliferation.
|
26129954 |
2015 |
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Our results indicate that BAI1 and TIMP-2 expressions in the extraneoplastic mucosa and non-metastatic lymph nodes were not suppressed in the patients with good prognosis, but increased expressions of angiopoietin 2, thrombospondin 2, TIMP-2, nm23 and E-cadherin in the tumor tissue did not lead to a long survival after operation.
|
11172604 |
2001 |
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
These findings significantly augment our knowledge of BAI1 by showing a novel post-translational mechanism regulating BAI1 activity through cancer-associated proteases, have important implications for BAI1 function and regulation, and present novel opportunities for therapy of cancer and other vascular diseases.
|
22330140 |
2012 |
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Furthermore, brain-specific angiogenesis inhibitor 1 expression that was lost in a selection of human cancer cell lines could be restored by wild-type p53 adenoviral transfection.
|
11875720 |
2002 |
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
BAI1 expression was slightly decreased in the cancer tissue.
|
10568831 |
1999 |
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
The emerging knowledge on cell- and site-specific function of BAI1 makes it both versatile and promising candidate for studies relating to cancer and host immune response.
|
28259299 |
2017 |
Glioblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Taken together, these data strongly indicate that BAI1 may be an excellent gene therapy candidate for the treatment of brain tumors, especially human glioblastomas.
|
16244591 |
2006 |
Glioblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
The expression of this gene, designated BAI1 (brain-specific angiogenesis inhibitor 1) was absent or significantly reduced in eight of nine glioblastoma cell lines, suggesting BAI1 plays a significant role in angiogenesis inhibition, as a mediator of p53.
|
9393972 |
1997 |
Glioblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
We have identified two novel human genes homologous to BAI1 (brain-specific angiogenesis inhibitor 1), an angiogenesis inhibitor that is a candidate for involvement in development of glioblastoma.
|
9533023 |
1997 |
Glioblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We generated an anti-BAI1 antibody and showed that BAI1 was widely expressed in normal brain but was absent in 28 glioma cell lines and in the majority of human glioblastoma investigated.
|
12507886 |
2003 |
Adult Glioblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Glioblastoma cells were transduced with an adenoviral vector encoding BAI1 (AdBAI1), and Northern and Western blot analyses, respectively, demonstrated BAI1 mRNA and protein expression in the transduced tumor cells.
|
16244591 |
2006 |
Adult Glioblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We generated an anti-BAI1 antibody and showed that BAI1 was widely expressed in normal brain but was absent in 28 glioma cell lines and in the majority of human glioblastoma investigated.
|
12507886 |
2003 |
Adult Glioblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
The expression of this gene, designated BAI1 (brain-specific angiogenesis inhibitor 1) was absent or significantly reduced in eight of nine glioblastoma cell lines, suggesting BAI1 plays a significant role in angiogenesis inhibition, as a mediator of p53.
|
9393972 |
1997 |
Adult Glioblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
We have identified two novel human genes homologous to BAI1 (brain-specific angiogenesis inhibitor 1), an angiogenesis inhibitor that is a candidate for involvement in development of glioblastoma.
|
9533023 |
1997 |
Childhood Glioblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Glioblastoma cells were transduced with an adenoviral vector encoding BAI1 (AdBAI1), and Northern and Western blot analyses, respectively, demonstrated BAI1 mRNA and protein expression in the transduced tumor cells.
|
16244591 |
2006 |
Childhood Glioblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We generated an anti-BAI1 antibody and showed that BAI1 was widely expressed in normal brain but was absent in 28 glioma cell lines and in the majority of human glioblastoma investigated.
|
12507886 |
2003 |
Childhood Glioblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
We have identified two novel human genes homologous to BAI1 (brain-specific angiogenesis inhibitor 1), an angiogenesis inhibitor that is a candidate for involvement in development of glioblastoma.
|
9533023 |
1997 |
Childhood Glioblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
The expression of this gene, designated BAI1 (brain-specific angiogenesis inhibitor 1) was absent or significantly reduced in eight of nine glioblastoma cell lines, suggesting BAI1 plays a significant role in angiogenesis inhibition, as a mediator of p53.
|
9393972 |
1997 |
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
These findings significantly augment our knowledge of BAI1 by showing a novel post-translational mechanism regulating BAI1 activity through cancer-associated proteases, have important implications for BAI1 function and regulation, and present novel opportunities for therapy of cancer and other vascular diseases.
|
22330140 |
2012 |