|
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Expression of the nonstructural protein (NS)3/4A protease in cells infected with hepatitis C virus (HCV) results in cleavage of the mitochondrial antiviral-signaling protein (MAVS) and disruption of signaling pathways that lead to viral activation of interferon regulatory factor 3 (IRF-3) and synthesis of type 1 interferons (IFN-alpha/beta).
|
18725224 |
2008 |
|
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A dominant active mutant of interferon (IFN) regulatory factor 7 (IRF7) and a negative regulator of HCV replication, VAP-C (Vesicle-associated membrane protein-associated protein subtype C), were fused with the C-terminal region of IPS-1 (IFNβ promoter stimulator-1), which includes an HCV protease cleavage site that was modified to be localized on the ER membrane, and designated cIRF7 and cVAP-C, respectively.
|
21253612 |
2011 |
|
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Relatively weak inducible IFN-β production in HBV infected patients with IPS-1 rs7269320 SNP or wild-type may contribute to chronic virus infection.
|
30930359 |
2019 |
|
MRSA - Methicillin resistant Staphylococcus aureus infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, agar dilution (MTT) helps to investigate outbreaks of methicillin-resistant Staphylococcus aureus (MRSA), VISA or VRSA.
|
31206950 |
2019 |
|
MRSA - Methicillin resistant Staphylococcus aureus infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Traditionally, it has been used as a drug of last resort; however, clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) strains with decreased susceptibility to vancomycin (vancomycin intermediate-resistant S. aureus [VISA]) and more recently with high-level vancomycin resistance (vancomycin-resistant S. aureus [VRSA]) have been described in the clinical literature.
|
24983424 |
2014 |
|
MRSA - Methicillin resistant Staphylococcus aureus infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
An isolate of the methicillin-resistant Staphylococcus aureus (MRSA) clone USA300 with reduced susceptibility to vancomycin (SG-R) (i.e, vancomycin-intermediate S. aureus, VISA) and its susceptible "parental" strain (SG-S) were recovered from a patient at the end and at the beginning of an unsuccessful vancomycin therapy.
|
22319446 |
2012 |
|
MRSA - Methicillin resistant Staphylococcus aureus infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MRSA with reduced susceptibility to glycopeptide antibiotics such as vancomycin (vancomycin intermediate S. aureus, VISA) have also emerged in the ocular infections, and there has been a rise in S. aureus resistance to new and old generation fluoroquinolones that are commonly used for prophylaxis after intravitreal injections and intraocular surgeries.
|
26679534 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Hence, this is the first demonstration that an uncommon genetic variant in the MAVS gene has a functional impact upon the anti-viral IFN pathway in vivo in humans and is associated with a novel sub-phenotype in SLE.
|
21268286 |
2011 |
|
Autoimmune Diseases
|
0.050 |
GeneticVariation
|
group |
BEFREE |
Persistent MAVS aggregates may lead to increased type I IFN production and result in unmitigated signals leading to autoimmunity.
|
27110677 |
2016 |
|
Hepatitis B
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Interferon β promoter stimulator 1 polymorphisms (IPS-1) regulate interferon (IFN) mediated viral clearance in hepatitis B virus (HBV) infection.
|
30930359 |
2019 |
|
West Nile viral infection
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Conversely, a B cell-specific deletion of MAVS had no effect on immune responses to WNV-MAD compared to WT controls.
|
31242236 |
2019 |
|
West Nile viral infection
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Here, we determined the role of mitochondrial antiviral-signaling protein (MAVS), the adaptor protein for RIG-I like receptor in regulating host immunity against the live attenuated West Nile virus (WNV) vaccine strain, the nonstructural (NS) 4B-P38G mutant.
|
28077630 |
2017 |
|
Vesicular Stomatitis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We previously demonstrated that the serine/threonine kinase IKKε is recruited to the C-terminal region of MAVS following Sendai or vesicular stomatitis virus (VSV) infection, mediated by Lys63-linked polyubiquitination of MAVS at Lys500, resulting in inhibition of downstream IFN signaling (Paz et al, Mol Cell Biol, 2009).
|
21200404 |
2011 |
|
Hepatitis B, Chronic
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Association of IPS1 polymorphisms with peginterferon efficacy in chronic hepatitis B with HBeAg-positive in the Chinese population.
|
25640825 |
2015 |
|
Leprosy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We hypothesized that the mitochondrial-related antimicrobial/antiviral immune genes MAVS (mitochondrial antiviral signaling protein), MITA (mediator of IRF3 activation) and MFN2 (mitofusin 2) would confer a risk to leprosy.
|
27553710 |
2016 |
|
Multiple Sclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Evaluation of 18 single nucleotide polymorphisms (SNPs) in the four genes did not reveal significant single-SNP associations with MS risk, but two VISA polymorphisms were modestly associated with age of onset.
|
25288302 |
2014 |
|
Respiratory Syncytial Virus Infections
|
0.010 |
GeneticVariation
|
group |
BEFREE |
To conclude, we could not replicate the previously reported association with SNPs in the IL4 and IL4R genes in our independent cohort, nor did we find that common SNPs in genes encoding for RLRs and the downstream adapter MAVS were associated with susceptibility to severe RSV infections.
|
24949794 |
2014 |
|
Complete atrioventricular block
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in IPS1 are independently associated with treatment response to PEG-IFN among Chinese HBeAg-positive CHB patients.
|
25640825 |
2015 |
|
Thyroid associated opthalmopathies
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These include the NO SPECS Classification, the European Group on Graves Orbitopathy severity scale, the Clinical Activity Score of Mourits, and the VISA Classification as outlined here.
|
29952931 |
2018 |
|
Sex Differentiation Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
It is also known that the adaptor proteins including apoptosis-associated speck-like protein containing CARD (ASC) and the mitochondrial antiviral signaling protein (MAVS) are necessary for NLRP3-dependent inflammasome function.
|
25149528 |
2014 |
|
Disorder of Achilles tendon
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study is to translate, culturally adapt, and validate the VISA-A questionnaire for Chilean Spanish speakers with Achilles tendinopathy (AT), which has been originally developed for English-speaking population.
|
30005676 |
2018 |
|
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
HCV-encoded NS3/4A protease plays an important role in HCV immune evasion by cleaving key adapter proteins VISA and TRIF of the RIG-I-like receptors and Toll-like receptors mediated interferon (IFN) induction pathways.
|
23137809 |
2013 |
|
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
HCV infection is supported by viral strategies to evade the innate antiviral response wherein the viral NS3.4A protease complex targets and cleaves the interferon promoter stimulator-1 (IPS-1) adaptor protein to ablate signaling of interferon alpha/beta immune defenses.
|
17289677 |
2007 |
|
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
Detailed studies revealed that HCV infection activates MAVS that in turn recruits TRAF6 via TRAF-interacting-motifs (TIMs), and TRAF6 subsequently directly recruits GP73 to MAVS via coiled-coil domain.
|
28394926 |
2017 |
|
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
The activity of asunaprevir-regulated innate immunity signal pathway was assessed with IFN-β promoter or IFN-stimulated responsive element (ISRE) reporter assays and immunoblotting of key signal proteins. siRNA-mediated MAVS and TRIF knockdown of cells was performed to assess the effect of asunaprevir-regulated innate immunity against HCV and DENV.
|
28473813 |
2017 |