CIP2A, cellular inhibitor of PP2A, 57650

N. diseases: 141; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression group BEFREE 863 consecutive colorectal cancer patients treated at Helsinki University Central Hospital in 1983–2001 were collected with 752 scored successfully for CIP2A immunohistochemical expression from tumor tissue microarrays. 22310977 2012
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. 15342917 2004
Clear-cell metastatic renal cell carcinoma
0.010 AlteredExpression disease BEFREE Clear cell RCC showed an even higher-CIP2A expression level than papillary or chromophobe RCC did. 22075943 2011
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
0.020 AlteredExpression disease BEFREE Helicobacter pylori enhances CIP2A expression and cell proliferation via JNK2/ATF2 signaling in human gastric cancer cells. 24398514 2014
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression group BEFREE CIP2A expression (mRNA and protein) was measured in three different sets of human mammary tumors and compared with clinicopathologic variables. 19671842 2009
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute
0.030 GeneticVariation disease BEFREE KIAA1524: A novel MLL translocation partner in acute myeloid leukemia. 20943269 2011
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.050 AlteredExpression disease BEFREE CIP2A expression and localization in oral carcinoma and dysplasia. 21068540 2010
CUI: C0151546
Disease: Oral Cavity Carcinoma
Oral Cavity Carcinoma
0.020 AlteredExpression disease BEFREE CIP2A expression and localization in oral carcinoma and dysplasia. 21068540 2010
CUI: C1608408
Disease: Malignant transformation
Malignant transformation
0.020 Biomarker phenotype BEFREE CIP2A may play a significant role in oral malignant transformation and therefore, it may be a potential target for chemotherapy of OSCC. 21068540 2010
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.020 AlteredExpression disease BEFREE CIP2A mRNA expression was higher in RA FLS compared with those in OA FLS, but did not reach statistical significance (P = 0.076). 21479604 2012
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.070 Biomarker disease BEFREE Cancerous inhibitor of PP2A (CIP2A) is a recently described inhibitor of PP2A in breast and gastric cancer. 21490338 2011
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.070 Biomarker disease BEFREE Cancerous inhibitor of PP2A (CIP2A) is a recently described inhibitor of PP2A in breast and gastric cancer. 21490338 2011
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 AlteredExpression group BEFREE CIP2A is overexpressed in cervical cancer and promotes the malignant growth of cervical cancer cells. 21575984 2011
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.040 Biomarker disease BEFREE CIP2A protein was detected in 52.8% of cervical cancer (n=72) and 12.5% of CIN III tissues (n=24) but not in normal (n=15), CIN I (n=21) or CIN II samples (n=25). 21575984 2011
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.040 Biomarker disease BEFREE CIP2A protein was detected in 52.8% of cervical cancer (n=72) and 12.5% of CIN III tissues (n=24) but not in normal (n=15), CIN I (n=21) or CIN II samples (n=25). 21575984 2011
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.040 Biomarker disease BEFREE CIP2A protein was detected in 52.8% of cervical cancer (n=72) and 12.5% of CIN III tissues (n=24) but not in normal (n=15), CIN I (n=21) or CIN II samples (n=25). 21575984 2011
CUI: C0851140
Disease: Carcinoma in situ of uterine cervix
Carcinoma in situ of uterine cervix
0.010 Biomarker disease BEFREE CIP2A protein was detected in 52.8% of cervical cancer (n=72) and 12.5% of CIN III tissues (n=24) but not in normal (n=15), CIN I (n=21) or CIN II samples (n=25). 21575984 2011
Cervical intraepithelial neoplasia grade 1
0.010 Biomarker disease BEFREE CIP2A protein was detected in 52.8% of cervical cancer (n=72) and 12.5% of CIN III tissues (n=24) but not in normal (n=15), CIN I (n=21) or CIN II samples (n=25). 21575984 2011
Cervical intraepithelial neoplasia grade 2
0.010 Biomarker disease BEFREE CIP2A protein was detected in 52.8% of cervical cancer (n=72) and 12.5% of CIN III tissues (n=24) but not in normal (n=15), CIN I (n=21) or CIN II samples (n=25). 21575984 2011
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker group BEFREE Cancerous inhibitor of PP2A (CIP2A) is a human oncoprotein inhibiting PP2A in many human malignancies. 21655278 2011
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker phenotype BEFREE Cancerous inhibitor of protein phosphatase 2A may be a novel target for prevention and treatment of RCC metastasis and recurrence. 22075943 2011
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.060 Biomarker disease BEFREE CIP2A was an independent prognostic factor in colon cancer after controlling for other clinical confounding factors, such as stage and lymphovascular invasion, particularly in stages III and IV (hazard ratio = 2.974, P < 0.001). 22328001 2012
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.060 Biomarker disease BEFREE CIP2A was an independent prognostic factor in colon cancer after controlling for other clinical confounding factors, such as stage and lymphovascular invasion, particularly in stages III and IV (hazard ratio = 2.974, P < 0.001). 22328001 2012
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker phenotype BEFREE CIP2A was an independent prognostic factor in colon cancer after controlling for other clinical confounding factors, such as stage and lymphovascular invasion, particularly in stages III and IV (hazard ratio = 2.974, P < 0.001). 22328001 2012
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression group BEFREE Cancerous inhibitor of protein phosphatase 2A (CIP2A) is highly expressed in hepatocellular carcinoma (HCC) and promotes cell proliferation, cell invasion, and aggressive tumor behavior. 22847158 2012