Glioblastoma Multiforme
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We have identified SKIP3, a novel human kinase-like gene, which is overexpressed in multiple human tumors and is regulated by hypoxia.
|
12743605 |
2003 |
Mammary Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
We show that the normal tissue expression of SKIP3 is confined to human liver, while multiple primary human lung, colon, and breast tumors express high levels of SKIP3 transcript.
|
12743605 |
2003 |
Anoxia
|
0.010 |
AlteredExpression
|
phenotype |
LHGDN |
We have identified SKIP3, a novel human kinase-like gene, which is overexpressed in multiple human tumors and is regulated by hypoxia.
|
12743605 |
2003 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest that, by interfering with Akt activation, TRB3 contributes to insulin resistance in individuals with susceptibility to type II diabetes.
|
12791994 |
2003 |
Hyperglycemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Hepatic overexpression of TRB3 in amounts comparable to those in db/db mice promoted hyperglycemia and glucose intolerance.
|
12791994 |
2003 |
Impaired glucose tolerance
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Hepatic overexpression of TRB3 in amounts comparable to those in db/db mice promoted hyperglycemia and glucose intolerance.
|
12791994 |
2003 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate a link between nuclear hormone receptor and insulin signaling pathways, and suggest a potential role for TRB-3 inhibitors in the treatment of type 2 diabetes.
|
15107844 |
2004 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker
|
disease |
BEFREE |
TRB3, a mammalian tribbles homolog, whose chromosomal region 20p13-p12 has been linked to human type 2 diabetes, impairs insulin signaling through the inhibition of Akt phosphorylation and is overexpressed in murine models of insulin resistance.
|
16123373 |
2005 |
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
To test the functional role of TRB3 variants, either Q84 or R84 TRB3 full-length cDNAs were transfected in human HepG2 hepatoma cell lines.
|
16123373 |
2005 |
Liver neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
To test the functional role of TRB3 variants, either Q84 or R84 TRB3 full-length cDNAs were transfected in human HepG2 hepatoma cell lines.
|
16123373 |
2005 |
Coronary Arteriosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
This finding provides a plausible biological background for the deleterious role of TRIB3 R84 on genetic susceptibility to coronary artery disease.
|
18436806 |
2008 |
Coronary heart disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
This finding provides a plausible biological background for the deleterious role of TRIB3 R84 on genetic susceptibility to coronary artery disease.
|
18436806 |
2008 |
Coronary Artery Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
This finding provides a plausible biological background for the deleterious role of TRIB3 R84 on genetic susceptibility to coronary artery disease.
|
18436806 |
2008 |
Myocardial Infarction
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We have recently described a Q84R gain-of-function polymorphism of TRIB3 with the R84 variant being associated with insulin resistance and an earlier age at myocardial infarction.
|
18436806 |
2008 |
Metabolic Syndrome X
|
0.330 |
Biomarker
|
disease |
CTD_human |
Our investigation aims at exploring the relationship between metabolic syndrome and TRB3 mRNA expression in adipose tissue of rats.
|
18497449 |
2008 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The objective of the study was to verify the association of TRIB3 Q84R with: 1) T2D, either subtyped or not according to age at diagnosis (early-onset, <45 yr, or >or= 45 yr); 2) insulin secretion and sensitivity in nondiabetic individuals; or 3) in vitro insulin secretion from isolated human islets.
|
18984671 |
2009 |
Degenerative polyarthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TRB3 protein levels were low in cells from normal cartilage but significantly increased in cells from OA cartilage.
|
19180501 |
2009 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of TRB3 gene Q84R polymorphism with type 2 diabetes mellitus in Chinese population.
|
19291425 |
2009 |
Metabolic Syndrome X
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Individuals with the functional TRIB3 Q84R polymorphism are at risk for MetS.
|
19389818 |
2009 |
Obesity
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The TRIB3 R84 allele especially predisposes to carotid atherosclerosis in part through the effects of abdominal obesity, hypertriglyceridemia, and insulin resistance.
|
19389818 |
2009 |
Carotid Atherosclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The TRIB3 R84 allele especially predisposes to carotid atherosclerosis in part through the effects of abdominal obesity, hypertriglyceridemia, and insulin resistance.
|
19389818 |
2009 |
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A total of 20 cancer cell lines (90.9%) expressed the TRIB3 gene.
|
19904274 |
2009 |
Primary malignant neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A total of 20 cancer cell lines (90.9%) expressed the TRIB3 gene.
|
19904274 |
2009 |
Colorectal Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Previous studies have shown that TRIB3 controls the cell growth through ubiquitination-dependent degradation of other proteins, whereas its significance in the prognosis of colorectal cancer (CRC) is not yet fully understood.
|
19904274 |
2009 |