Disease: leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023418
Disease: leukemia
leukemia 		0.400 GeneticVariation disease BEFREE Activating mutations of SHP2 have been associated with developmental pathologies such as Noonan syndrome and are found in multiple cancer types, including leukaemia, lung and breast cancer and neuroblastoma. 27362227 2016
CUI: C0023418
Disease: leukemia
leukemia 		0.400 Biomarker disease BEFREE SHP2 has been shown to contribute to the progression of a number of cancer types including leukemia, gastric, and breast cancers. 29155585 2017
CUI: C0023418
Disease: leukemia
leukemia 		0.400 GeneticVariation disease BEFREE Here we show that the interaction between leukemia-associated mutant Shp2 and Gab2, a scaffolding protein important for cytokine-induced PI3K/Akt signaling, was enhanced, and that the mTOR pathway was elevated in Ptpn11<sup>E76K/+</sup> leukemic cells. 27840422 2017
CUI: C0023418
Disease: leukemia
leukemia 		0.400 Biomarker disease BEFREE CD244 maintains the proliferation ability of leukemia initiating cells through SHP-2/p27<sup>kip1</sup> signaling. 28126968 2017
CUI: C0023418
Disease: leukemia
leukemia 		0.400 GeneticVariation disease BEFREE Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia. 30018082 2018
CUI: C0023418
Disease: leukemia
leukemia 		0.400 GeneticVariation disease BEFREE Genetic mutations in the phosphatase PTPN11 (SHP2) are associated with childhood leukemias. 30457860 2019