|
Herpesviridae Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Zhangfei (ZF) is a basic region-leucine zipper protein that has been implicated in herpesvirus infection cycle and related cellular processes.
|
16343488 |
2006 |
|
Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
UW228, another medulloblastoma cell-line, was also susceptible to the suppressive effects of resveratrol and Zhangfei.
|
18719857 |
2009 |
|
Childhood Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
UW228, another medulloblastoma cell-line, was also susceptible to the suppressive effects of resveratrol and Zhangfei.
|
18719857 |
2009 |
|
Adult Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
UW228, another medulloblastoma cell-line, was also susceptible to the suppressive effects of resveratrol and Zhangfei.
|
18719857 |
2009 |
|
Nasal Type Extranodal NK/T-Cell Lymphoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The EBV-DNA amount in whole blood was useful for predicting tumor response, toxicity, and prognosis after SMILE chemotherapy for ENKL.
|
22675173 |
2012 |
|
Lymphoma
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Extranodal NK/T-cell lymphoma, nasal type (ENKL) is an Epstein-Barr virus (EBV)-associated lymphoma for which a new chemotherapeutic regimen called SMILE (steroid, methotrexate, ifosfamide, L-asparaginase, and etoposide) recently showed promising results.
|
22675173 |
2012 |
|
Leukopenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The incidence of grade 4 toxicity of SMILE other than leukopenia/neutropenia was significantly higher in patients with 10(5) copies/mL of EBV-DNA or more in whole blood (100% vs. 29%, P = 0.007) than that of others and in patients with 10(4) copies/mL or more in plasma (86% vs. 26%, P = 0.002).
|
22675173 |
2012 |
|
Neutropenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The incidence of grade 4 toxicity of SMILE other than leukopenia/neutropenia was significantly higher in patients with 10(5) copies/mL of EBV-DNA or more in whole blood (100% vs. 29%, P = 0.007) than that of others and in patients with 10(4) copies/mL or more in plasma (86% vs. 26%, P = 0.002).
|
22675173 |
2012 |
|
Adult Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Extranodal NK/T-cell lymphoma, nasal type (ENKL) is an Epstein-Barr virus (EBV)-associated lymphoma for which a new chemotherapeutic regimen called SMILE (steroid, methotrexate, ifosfamide, L-asparaginase, and etoposide) recently showed promising results.
|
22675173 |
2012 |
|
Childhood Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Extranodal NK/T-cell lymphoma, nasal type (ENKL) is an Epstein-Barr virus (EBV)-associated lymphoma for which a new chemotherapeutic regimen called SMILE (steroid, methotrexate, ifosfamide, L-asparaginase, and etoposide) recently showed promising results.
|
22675173 |
2012 |
|
Nasal Type Extranodal NK/T-Cell Lymphoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
P-glycoprotein is a product of the multidrug resistance (MDR1) gene, which is a major cause of the refractoriness of malignant lymphomas to conventional chemotherapeutic regimens containing anthracycline. l-asparaginase-containing regimens such as SMILE (steroid, methotrexate, ifosfamide, l-asparaginase, and etoposide) are effective for ENKL.
|
23768637 |
2013 |
|
Lymphoma
|
0.020 |
Biomarker
|
group |
BEFREE |
P-glycoprotein is a product of the multidrug resistance (MDR1) gene, which is a major cause of the refractoriness of malignant lymphomas to conventional chemotherapeutic regimens containing anthracycline. l-asparaginase-containing regimens such as SMILE (steroid, methotrexate, ifosfamide, l-asparaginase, and etoposide) are effective for ENKL.
|
23768637 |
2013 |
|
Acute myocardial infarction
|
0.020 |
Biomarker
|
disease |
BEFREE |
The four SMILE studies demonstrated that early administration of zofenopril following acute myocardial infarction is prognostically beneficial compared to placebo or other angiotensin-converting enzyme (ACE) inhibitors.
|
28155333 |
2017 |
|
Acute myocardial infarction
|
0.020 |
Biomarker
|
disease |
BEFREE |
The SMILE-4 study showed that in patients with left ventricular dysfunction (LVD) after acute myocardial infarction, early treatment with zofenopril plus acetyl salicylic acid is associated with an improved 1-year survival, free from death or hospitalization for cardiovascular (CV) causes, as compared to ramipril plus acetyl salicylic acid.
|
28195948 |
2017 |
|
Dental caries
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>Methods</i>: The SMILE-FFQ was designed to capture the leading dietary contributors to dental caries risk in toddlers aged 18-30 months via a proxy report.
|
29117133 |
2017 |
|
Myopia
|
0.030 |
Biomarker
|
disease |
BEFREE |
A retrospective case series was conducted at Eye subspecialty center, Cairo, Egypt on 9 eyes with myopia or myopic astigmatism (spherical equivalent - 8.0 and - 12.0D). undergoing SMILE procedure and needed second interference.
|
29454328 |
2018 |
|
Heart failure
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Efficacy and Safety of Zofenopril Versus Ramipril in the Treatment of Myocardial Infarction and Heart Failure: A Review of the Published and Unpublished Data of the Randomized Double-Blind SMILE-4 Study.
|
29667144 |
2018 |
|
Congestive heart failure
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Efficacy and Safety of Zofenopril Versus Ramipril in the Treatment of Myocardial Infarction and Heart Failure: A Review of the Published and Unpublished Data of the Randomized Double-Blind SMILE-4 Study.
|
29667144 |
2018 |
|
Adenoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Thus, we identified three miRNAs (hsa-miR-421, hsa-miR-29b-1-5p, and hsa-miR-27b-5p) with two mRNAs (FBXO11 and CREBZF) that might play an important role in the GC development from premalignant adenomas.
|
29725252 |
2018 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Smartphone problem-solving and behavioural activation therapy to reduce fear of recurrence among patients with breast cancer (SMartphone Intervention to LEssen fear of cancer recurrence: SMILE project): protocol for a randomised controlled trial.
|
30413519 |
2018 |
|
Dry Eye Syndromes
|
0.010 |
Biomarker
|
disease |
BEFREE |
A new type of corneal refractive surgery, SMILE, which has less impact on corneal nerves, induces less postoperative dry eye, supporting the association between corneal denervation and postoperative dry eye.
|
30481814 |
2018 |
|
Epilepsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
To determine the effectiveness and cost-effectiveness of Self-Management education for people with poorly controlled epILEpsy [SMILE (UK)].
|
29717699 |
2018 |
|
Fatty Liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Hepatic CREBZF couples insulin to lipogenesis by inhibiting insig activity and contributes to hepatic steatosis in diet-induced insulin-resistant mice.
|
29637572 |
2018 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, we identified three miRNAs (hsa-miR-421, hsa-miR-29b-1-5p, and hsa-miR-27b-5p) with two mRNAs (FBXO11 and CREBZF) that might play an important role in the GC development from premalignant adenomas.
|
29725252 |
2018 |
|
Myocardial Infarction
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Efficacy and Safety of Zofenopril Versus Ramipril in the Treatment of Myocardial Infarction and Heart Failure: A Review of the Published and Unpublished Data of the Randomized Double-Blind SMILE-4 Study.
|
29667144 |
2018 |