|
Amyotrophic Lateral Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data also imply that restoring Rab1-mediated ER-Golgi transport is a novel therapeutic target in ALS.
|
26298469 |
2015 |
|
Aspirin exacerbated respiratory disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
The RAB1A gene may play a role in the development of AERD in asthmatics and the genetic polymorphisms of the gene have the potential to be used as an indicator of this disease.
|
24555545 |
2014 |
|
aspirin intolerance
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Thus, functional alterations of the RAB1A gene may contribute to aspirin intolerance in asthmatic sufferers.
|
24555545 |
2014 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The RAB1A gene may play a role in the development of AERD in asthmatics and the genetic polymorphisms of the gene have the potential to be used as an indicator of this disease.
|
24555545 |
2014 |
|
Ataxia Telangiectasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To investigate the relationship between single-nucleotide polymorphisms (SNPs) in the RAB1A gene and aspirin-exacerbated respiratory disease (AERD), asthmatics (n=1197) were categorized into AERD and aspirin-tolerant asthma (ATA).
|
24555545 |
2014 |
|
Bladder Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, MNX1-AS1 functions as a sponge to miR-218-5p to modulate RAB1A expression in bladder cancer, which suggests that MNX1-AS1 might serve as a novel therapeutic target and a novel biomarker for metastasis and prognosis in bladder cancer.
|
31843814 |
2020 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Emerging evidence has verified that Rab1A plays an oncogenic role in several human malignancies including breast cancer, lung cancer, and hepatocellular carcinomas.
|
30058685 |
2018 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Taken together, these data suggest that miR‑139‑3p plays a tumor suppressive role in breast cancer by targeting RAB1A and may serve as a potential new biomarker for breast cancer prognosis.
|
31485677 |
2019 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Then, MTT cell proliferation, colony formation, cell invasion and wound healing assays were performed to characterize the function of RAB1A in the breast cancer cell lines.
|
28184936 |
2017 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Thus, our results suggest that rapid characterisation of the target gene(s) for TSCCs can be accomplished using our in-house cDNA microarray analysis combined with the qRT-PCR and immunohistochemistry, and that the Rab1A is a potential biomarker of tongue carcinogenesis.
|
15870709 |
2005 |
|
Carcinoma
|
0.020 |
Biomarker
|
group |
BEFREE |
Residual LNM (ypN+) were found in 6%, 20.8% and 21.4% of patients with ypT0, ypT1 and ypT2 carcinomas, respectively.
|
29929861 |
2018 |
|
Carcinoma
|
0.020 |
Biomarker
|
group |
BEFREE |
Expression of the ADS31/YPT1, ADS39 and TRPM-2 genes was sensitive to androgen withdrawal and replacement both in the parent androgen-dependent and the recurrent androgen-independent carcinomas.
|
8049130 |
1994 |
|
Carcinoma of bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, MNX1-AS1 functions as a sponge to miR-218-5p to modulate RAB1A expression in bladder cancer, which suggests that MNX1-AS1 might serve as a novel therapeutic target and a novel biomarker for metastasis and prognosis in bladder cancer.
|
31843814 |
2020 |
|
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data suggested that Rab1A may be involved in the pathogenesis of human lung cancer in an mTOR- and MAPK-independent manner.
|
27902464 |
2016 |
|
Cardiomyopathies
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Moreover, deregulation of RAB1 expression has been linked to a myriad of human diseases such as cancer, cardiomyopathy and Parkinson's disease.
|
27041585 |
2016 |
|
Cardiomyopathy, Dilated
|
0.200 |
Biomarker
|
group |
MGD |
|
|
|
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Coimmunoprecipitation assay showed that OPTN interacted with Rab1, the mammalian homolog of yeast Ypt1, in N2a mouse neuroblastoma cell line.
|
28843006 |
2018 |
|
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Coimmunoprecipitation assay showed that OPTN interacted with Rab1, the mammalian homolog of yeast Ypt1, in N2a mouse neuroblastoma cell line.
|
28843006 |
2018 |
|
Colorectal Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
RAB1A acts as an oncogene in various cancers, and emerging evidence has verified that RAB1A is an mTORC1 activator in hepatocellular and colorectal cancer, but the role of RAB1A in breast cancer remains unclear.
|
28184936 |
2017 |
|
Colorectal Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
The level of p‑S6K1 was markedly high in CRC tissues and Rab1A expression level had a positive association with p‑S6K1 level.
|
30896866 |
2019 |
|
Colorectal Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry and western blot were conducted to determine the RAB1A expression in CRC tissues and cells, respectively.
|
31598673 |
2020 |
|
Colorectal Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Previous studies have reported an oncogenic function of Rab1A in colorectal cancer and hepatocellular carcinomas via the mTOR pathway.
|
31527621 |
2019 |
|
Colorectal Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Moreover, Kaplan-Meier survival analysis showed that patients with high Rab1A expression had a significantly worse survival time than those with low Rab1A expression, which especially affected the survival in CRC patients with advanced stage.
|
30058685 |
2018 |
|
Congenital Disorders of Glycosylation
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We demonstrate that the COG complex cooperates with Rab1 and Golgi phosphoprotein 3 to regulate Golgi trafficking and that overexpression of Rab1 can rescue the cytokinesis and locomotor defects associated with loss of Cog7<i>.</i> Our results suggest that the <i>Drosophila</i> COG7-CDG model can be used to test novel potential therapeutic strategies by modulating trafficking pathways.
|
28883096 |
2017 |
|
Congestive heart failure
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In multiple independent mouse lines, Rab1a overexpression caused cardiac hypertrophy that progressed in a time- and transgene dose-dependent manner to heart failure.
|
11739277 |
2001 |