|
Lymphoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Next-generation sequencing analysis of the tumorous and normal tissue detected a pathogenic germline mutation of the FAM175A gene and somatic mutations in BRCA2 and RAD51B (in both sarcoma and lymphoma specimens), and INPP4B and RICTOR (in lymphoma specimen only).
|
31361614 |
2020 |
|
Colon Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Rs1800734 (in MLH1 gene) was associated with colon cancer risk (p-value = 3.5 × 10<sup>-6</sup> ) and rs2189517 (in RAD51B) with rectal cancer risk (p-value = 5.7 × 10<sup>-6</sup> ).
|
31209889 |
2020 |
|
Sarcoma
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Next-generation sequencing analysis of the tumorous and normal tissue detected a pathogenic germline mutation of the FAM175A gene and somatic mutations in BRCA2 and RAD51B (in both sarcoma and lymphoma specimens), and INPP4B and RICTOR (in lymphoma specimen only).
|
31361614 |
2020 |
|
Adult Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Next-generation sequencing analysis of the tumorous and normal tissue detected a pathogenic germline mutation of the FAM175A gene and somatic mutations in BRCA2 and RAD51B (in both sarcoma and lymphoma specimens), and INPP4B and RICTOR (in lymphoma specimen only).
|
31361614 |
2020 |
|
Childhood Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Next-generation sequencing analysis of the tumorous and normal tissue detected a pathogenic germline mutation of the FAM175A gene and somatic mutations in BRCA2 and RAD51B (in both sarcoma and lymphoma specimens), and INPP4B and RICTOR (in lymphoma specimen only).
|
31361614 |
2020 |
|
Malignant neoplasm of soft tissue
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Next-generation sequencing analysis of the tumorous and normal tissue detected a pathogenic germline mutation of the FAM175A gene and somatic mutations in BRCA2 and RAD51B (in both sarcoma and lymphoma specimens), and INPP4B and RICTOR (in lymphoma specimen only).
|
31361614 |
2020 |
|
Fanconi Anemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Deficiency in several of the classical human RAD51 paralogs [RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3] is associated with cancer predisposition and Fanconi anemia.
|
31584931 |
2019 |
|
Myopia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Guinea pigs in the REC groups also wore the facemask for 21 days to induce myopia; then, the facemask was removed, and the eye was re-exposed to the normal environment for 12 hours (REC ½ group), 1 day (REC 1 group), 2 days (REC 2 group), and 7 days (REC 7 group).
|
31697570 |
2019 |
|
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Deficiency in several of the classical human RAD51 paralogs [RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3] is associated with cancer predisposition and Fanconi anemia.
|
31584931 |
2019 |
|
Glycogen storage disease type II
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among genetic variables, SNPs of CFH, ARMS2, IL-8, TIMP3, SLC16A8, RAD51B, VEGFA and COL8A1 were significantly associated with the risk of AMD in the Italian cohort.
|
29197628 |
2018 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results serve as a foundation for the investigation of the role of RAD51B in NSCLC, which may lead to potential therapeutic innovations.
|
29207658 |
2017 |
|
Parkinson Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
The protein-product of RAD51B interacts with that of its paralogue RAD51, which is associated with congenital mirror movements phenotypes, a phenotype also comorbid with PD.
|
28117402 |
2017 |
|
Myocardial Ischemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This longitudinal study thus analyses whether four common polymorphisms (rs2155209, rs7963551, rs17105278, rs2735383) in four selected DSB repair genes (MRE11A, RAD52, RAD51B, NBS1) influence the hazard of age-adjusted death in a cohort of patients with typical symptoms of ischemic heart disease.
|
29024686 |
2017 |
|
Superficial ulcer
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of RAD51B are associated with rheumatoid arthritis and erosion in rheumatoid arthritis patients.
|
28361912 |
2017 |
|
Mirror movements disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
The protein-product of RAD51B interacts with that of its paralogue RAD51, which is associated with congenital mirror movements phenotypes, a phenotype also comorbid with PD.
|
28117402 |
2017 |
|
Coronary Artery Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Of only 5 RA-associated SNP showing p values for CAD < 0.05, 4 loci (C5orf30, IL-6R, PTPN22, and RAD51B) showed directionality-consistent effects on CAD, and 1 (rs10774624, locus SH2B3) reached study-wide significance (p = 7.29E-06).
|
27744395 |
2017 |
|
Skin Erosion
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of RAD51B are associated with rheumatoid arthritis and erosion in rheumatoid arthritis patients.
|
28361912 |
2017 |
|
Female Breast Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Common variation on 14q24.1, close to RAD51B, has been associated with breast cancer: rs999737 and rs2588809 with the risk of female breast cancer and rs1314913 with the risk of male breast cancer.
|
27149063 |
2016 |
|
Malignant tumor of cervix
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In summary, our study suggested that miRNA-binding site genetic variants of RAD51B may modify the susceptibility to cervical cancer, which is important to identify individuals with differential risk for this malignancy and to improve the effectiveness of preventive intervention.
|
27334422 |
2016 |
|
Fibroid Tumor
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RAD51 paralog B (RAD51B), the preferential translocation partner of HMGA2, was up-regulated in MED12 mutant lesions, suggesting a role for this gene in the genesis of leiomyomas.
|
26787895 |
2016 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
To evaluate clinicopathological and prognostic significance of RAD51B in GC, we examined messenger RNA (mRNA) and protein expression via quantitative real-time polymerase chain reaction (qRT-PCR) from 69 and tissue microarray from 144 GC patients, respectively.
|
27651161 |
2016 |
|
Malignant neoplasm of female breast
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Common variation on 14q24.1, close to RAD51B, has been associated with breast cancer: rs999737 and rs2588809 with the risk of female breast cancer and rs1314913 with the risk of male breast cancer.
|
27149063 |
2016 |
|
Breast Cancer, Familial
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that loss-of-function mutations in RAD51B are rare, but common variation at the RAD51B region is significantly associated with familial breast cancer risk.
|
27149063 |
2016 |
|
Hyperactive behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, RAD51B may act as an oncogene during GC progression, and its hyper-expression may be a potential biomarker for early detection and poor prognosis of GC.
|
27651161 |
2016 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, high level of RAD51B protein was correlated with advanced stage (P = 0.009), aggressive differentiation (P = 0.022), and lymph node metastasis (P = 0.001).
|
27651161 |
2016 |