|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Pre-clinical observation highlighted that triple negative (estrogen receptor/progesterone receptor/human epidermal growth factor receptor)-breast cancer cells displayed resistance to retinoids due to the RARγ high expression profile.
|
29849791 |
2018 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Potential role for retinoic acid receptor-gamma in the inhibition of breast cancer cells by selective retinoids and interferons.
|
8603404 |
1996 |
|
Childhood Leukemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
The regulation of the subcellular content of CDK1 and RARγ by ATRA is an important process for achieving an effective response in treatment of leukemia.
|
23518499 |
2013 |
|
Childhood Leukemia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Critical role of retinoid/rexinoid signaling in mediating transformation and therapeutic response of NUP98-RARG leukemia.
|
25510432 |
2015 |
|
Childhood Leukemia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
RARA and RARG gene downregulation associated with EZH2 mutation in acute promyelocytic-like morphology leukemia.
|
29530751 |
2018 |
|
Liver carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Oncogenic potential of retinoic acid receptor-gamma in hepatocellular carcinoma.
|
20197465 |
2010 |
|
Liver carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Given the implication of AKT-p53 dysregulation in most HCC, targeting the non-genomic signaling of RARγ that switches AKT-p53 from a pro-survival to a pro-apoptotic program in cancer cells should be a promising strategy for developing novel anti-HCC drugs.
|
28336971 |
2017 |
|
Liver carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Retinoic acid receptor γ (RARγ), a unique member of the nuclear receptor superfamily, plays an important role in the progression of several cancers such as hepatocellular carcinoma, esophageal cancer, and cholangiocarcinoma.
|
28272990 |
2017 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Collectively, these results suggested that overexpression of RARγ contributed to the multidrug chemoresistance of CRC cells, at least in part due to upregulation of MDR1 via activation of the Wnt/β-catenin pathway, indicating that RARγ might serve as a potential therapeutic target for chemoresistant CRC patients.
|
28272990 |
2017 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Collectively, our results defined RARγ as tumor suppressor in colorectal cancer that acts by restricting oncogenic signaling by the Hippo-Yap pathway, with potential implications for new approaches to colorectal cancer therapy.
|
27325643 |
2016 |
|
Fibrodysplasia Ossificans Progressiva
|
0.020 |
Biomarker
|
disease |
BEFREE |
Palovarotene, a retinoic acid receptor-gamma (RARγ) agonist, has been proposed as a possible treatment for fibrodysplasia ossificans progressiva (FOP) and is a potent inhibitor of HEO in mouse models.
|
28963080 |
2018 |
|
Fibrodysplasia Ossificans Progressiva
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In addition, an RAR-γ agonist blocked heterotopic ossification in transgenic mice expressing activin receptor-like kinase-2 (ALK2) Q207D, a constitutively active form of the receptor that is related to ALK2 R206H found in individuals with fibrodysplasia ossificans progressiva.
|
21460849 |
2011 |
|
Neuroblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that retinoic acid receptor gamma (RARG) expression was decreased, whereas miR-124 expression was increased during neural differentiation in mouse Neuroblastoma (N2a) Cells, P19 embryonal carcinoma (P19) cells, and mouse brain, as detected by immunoblotting or RT-qPCR.
|
31170403 |
2020 |
|
Neuroblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We, firstly, examined primary NB tumor tissue for a correlation between endogenous RAR gamma expression and clinical stage of the tumor and secondly, the effects of exogenous over-expression of the RAR gamma gene on a human NB tumor cell line.
|
7630632 |
1995 |
|
Cholangiocarcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Retinoic acid receptor γ (RARγ), a unique member of the nuclear receptor superfamily, plays an important role in the progression of several cancers such as hepatocellular carcinoma, esophageal cancer, and cholangiocarcinoma.
|
28272990 |
2017 |
|
Cholangiocarcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
However, the role of RARγ in cholangiocarcinoma (CCA), chemoresistant bile duct carcinoma with a poor prognosis, remains unclear.
|
23798555 |
2013 |
|
Papillary thyroid carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
A similar effect of AIT was observed with a decrease in RARγ expression in PTC/AIT+ patients.
|
31579073 |
2019 |
|
Papillary thyroid carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Moreover, we found significantly increased expression of RARα and RARγ in the overall group of PTC.
|
23969901 |
2013 |
|
Leukemogenesis
|
0.020 |
Biomarker
|
disease |
BEFREE |
These uncovered fusion genes strongly suggested their contributions to leukemogenesis as driver alternations and APL phenotype may arise by abnormalities of other members of the nuclear receptor superfamily involved in retinoid signaling (RARB or RARG) or even by mechanisms distinct from the formation of aberrant retinoid receptors.
|
30575821 |
2019 |
|
Leukemogenesis
|
0.020 |
Biomarker
|
disease |
BEFREE |
These data suggest that RAR alpha is necessary for appropriate response of the RAR beta and RAR gamma genes to physiologic changes and deregulation of the RAR alpha in transgenic mice, which resulted in upregulation of RAR beta and RAR gamma, can be associated with lymphomagenesis.
|
9116296 |
1997 |
|
Central neuroblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We, firstly, examined primary NB tumor tissue for a correlation between endogenous RAR gamma expression and clinical stage of the tumor and secondly, the effects of exogenous over-expression of the RAR gamma gene on a human NB tumor cell line.
|
7630632 |
1995 |
|
Central neuroblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that retinoic acid receptor gamma (RARG) expression was decreased, whereas miR-124 expression was increased during neural differentiation in mouse Neuroblastoma (N2a) Cells, P19 embryonal carcinoma (P19) cells, and mouse brain, as detected by immunoblotting or RT-qPCR.
|
31170403 |
2020 |
|
Childhood Neuroblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that retinoic acid receptor gamma (RARG) expression was decreased, whereas miR-124 expression was increased during neural differentiation in mouse Neuroblastoma (N2a) Cells, P19 embryonal carcinoma (P19) cells, and mouse brain, as detected by immunoblotting or RT-qPCR.
|
31170403 |
2020 |
|
Childhood Neuroblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We, firstly, examined primary NB tumor tissue for a correlation between endogenous RAR gamma expression and clinical stage of the tumor and secondly, the effects of exogenous over-expression of the RAR gamma gene on a human NB tumor cell line.
|
7630632 |
1995 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
Collectively, our results defined RARγ as tumor suppressor in colorectal cancer that acts by restricting oncogenic signaling by the Hippo-Yap pathway, with potential implications for new approaches to colorectal cancer therapy.
|
27325643 |
2016 |