|
ovarian neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Survival analyses disclosed RIG-I as an independent marker of poor outcome in OC.
|
31800094 |
2020 |
|
Malignant neoplasm of ovary
|
0.010 |
Biomarker
|
disease |
BEFREE |
Survival analyses disclosed RIG-I as an independent marker of poor outcome in OC.
|
31800094 |
2020 |
|
Immunosuppression
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We conclude that high RIG-I expression associates with poor outcome in OC, which is explainable by local immunosuppression in the tumor bed.
|
31800094 |
2020 |
|
Noonan Syndrome 1
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We also observed that wild-type NS1 is capable of binding directly to the tandem RIG-I CARDs while the R21Q mutation in NS1 significantly inhibits this interaction.
|
31843969 |
2020 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
Survival analyses disclosed RIG-I as an independent marker of poor outcome in OC.
|
31800094 |
2020 |
|
Chorioamnionitis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Interestingly, STING, RIG-I, and TLR3 are all involved in viral response pathways, suggesting that fetuses exposed to chorioamnionitis or fetal inflammatory reaction might respond differently to viruses postnatally.
|
31421529 |
2019 |
|
Lymphopenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we aimed to determine retinoic acid-inducible gene I (RIG-I) expression in peripheral T lymphocytes and explore the correlation between RIG-I and T cell lymphopenia in DM.
|
31142372 |
2019 |
|
Melanoma, Experimental
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overall, our data demonstrate the potency of a novel combinatorial vaccination strategy combining RIG-I-driven immunization with CTLA-4 blockade to prevent and treat experimental melanoma.
|
30852164 |
2019 |
|
Orchitis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Moreover, RIG-I and TLR3 contributed to the modulation of poly I:C-triggered inflammatory cytokine generation during orchitis in testicular cells.
|
31195953 |
2019 |
|
Pancreatic carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nanoparticle Delivery of RIG-I Agonist Enables Effective and Safe Adjuvant Therapy in Pancreatic Cancer.
|
30545600 |
2019 |
|
Malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
It implies that the therapeutic effect of lipo-ATRA in lung cancer was exhibited by ameliorating the TIG3 expression and by suppressing the expression of PPARγ.
|
31300983 |
2019 |
|
Malignant neoplasm of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nanoparticle Delivery of RIG-I Agonist Enables Effective and Safe Adjuvant Therapy in Pancreatic Cancer.
|
30545600 |
2019 |
|
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
It implies that the therapeutic effect of lipo-ATRA in lung cancer was exhibited by ameliorating the TIG3 expression and by suppressing the expression of PPARγ.
|
31300983 |
2019 |
|
Primary malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
It implies that the therapeutic effect of lipo-ATRA in lung cancer was exhibited by ameliorating the TIG3 expression and by suppressing the expression of PPARγ.
|
31300983 |
2019 |
|
Tumor Immunity
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Activation of the innate immune receptor retinoic acid-inducible gene I (RIG-I) by its specific ligand 5'-triphosphate RNA (3pRNA) triggers anti-tumor immunity, which is dependent on natural killer (NK) cell activation and cytokine induction.
|
30230526 |
2019 |
|
Sjogren's Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Identification of the first endogenous mammalian microRNA that binds to RIG-I inducing IFN production but also demonstrate a novel pathophysiological underlying mechanism in which miR-1248 overexpression links two major pathways associated with SS, namely activation of IFN production with modulation of calcium signaling.
|
31597594 |
2019 |
|
Chronic Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The findings suggest that Klotho can suppress CKD-associated systemic inflammation through inhibiting IS-induced RIG-1/NF-κB activation and monocyte inflammatory factor release.
|
31207307 |
2019 |
|
IMMUNE SUPPRESSION
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We review related studies on mouse Adar1 mutant phenotypes, their rescues by preventing signaling from the antiviral RIG-I-like Sensors (RLRs), as well as Adar1 mechanisms in innate immune suppression and other roles of Adar1, including editing-independent effects.
|
30391332 |
2019 |
|
Swine influenza virus (viruses that normally cause infections in pigs)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Knockdown of RIG-I dramatically impaired the induction of IFN-β and ISG56 in NS1 Y73F or S83A mutant-infected cells, indicating that RIG-I plays a role in the IFN-β response upon rSIV NS1 Y73F and rSIV NS1 S83A infection.
|
31805964 |
2019 |
|
Middle East Respiratory Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Middle East Respiratory Syndrome Coronavirus-Encoded ORF8b Inhibits RIG-I-Like Receptors in a Differential Mechanism.
|
31838791 |
2019 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
PI3Kδ contributes to ER stress-associated asthma through ER-redox disturbances: the involvement of the RIDD-RIG-I-NF-κB axis.
|
29504610 |
2018 |
|
Hand, Foot and Mouth Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The results indicated that RIG-1 (rs3739674 and rs9695310) polymorphisms are associated with an increased risk of EV71-induced HFMD in Chinese children, whereas RIG-1 rs3739674 and TLR3 rs5743305 polymorphisms are associated with disease severity.
|
29235129 |
2018 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockdown of RIG-I was achieved by RNAi technology to examine the contribution of RIG-I in the regulation of biological functions in the cell lines of human gastric cancer.
|
30250402 |
2018 |
|
Pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Infected RIG-I KO animals displayed similar lung inflammation profiles as did WT mice, in terms of the protein concentration, total cell count, and inflammatory cell composition in the bronchoalveolar lavage fluid.
|
30532653 |
2018 |
|
Kaposi Sarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
RIG-I Detects Kaposi's Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner.
|
29970461 |
2018 |