|
Diastolic blood pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
|
30224653 |
2018 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association meta-analysis of functional outcome after ischemic stroke.
|
30796134 |
2019 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
|
Alzheimer's Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We found statistically significant association with AAO for three genes (WRN, NTN4 and LAMC3) with common associated variants, and for four genes (SLC8A3, SLC19A3, MADD and LRRK2) with multiple rare-associated variants that have a plausible biological function related to AD.
|
26394601 |
2015 |
|
IGA Glomerulonephritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In the Lee's grade III-V subgroup, the rs1369270 in NTN4 was significantly correlated with the risk of IgAN (p = 0.004).
|
30928649 |
2019 |
|
Secondary malignant neoplasm of liver
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
NT-4 overexpression also markedly decreased colorectal cancer progression in terms of tumor number and volume of liver metastases in the NT-4 group of the orthotopic liver metastasis model (25 vs. 90% and 4±1 vs. 709±190 mm3, p<0.001 and p<0.05).
|
23124703 |
2013 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Recent studies have indicated that netrin-4 also participates in the development of nonneural tissues and modulates tumor cell proliferation and tumor metastasis.
|
22496621 |
2012 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Netrin-4 (NTN4), a laminin-related protein, has been proposed as a key factor to target NB metastasis, although there is controversy about its function.
|
30160193 |
2019 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Nerve guidance factor 4 (Netrin-4, NTN4) is reduced in variety of malignancies and involved in tumor metastasis.
|
27840993 |
2017 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Together, these data provide evidence that Netrin-4 is a lymphangiogenic factor contributing to tumor dissemination and represents a potential target to inhibit metastasis formation.
|
20407033 |
2010 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
In vivo analysis, using the chicken embryo chorioallantoic membrane (CAM) model, showed that NEO1 and endogenous NTN4 are involved in tumor extravasation and metastasis.
|
28038459 |
2017 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Our study suggests that PXDN, NTN4 and GLIS3 play a functional role in promoting melanoma cellular invasion, and therapeutic approaches directed toward inhibiting the action of these proteins may reduce the incidence or progression of metastasis in melanoma patients.
|
27172792 |
2016 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Introduction of NTN4 into MCF7 cells suppressed cell growth, indicating that NTN4 has tumor suppressive activity.
|
19859801 |
2010 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Together, these data provide evidence that Netrin-4 is a lymphangiogenic factor contributing to tumor dissemination and represents a potential target to inhibit metastasis formation.
|
20407033 |
2010 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Public databases contain extensive information regarding the expression of NEO1 and its ligands Netrin-1 (NTN1) and Netrin-4 (NTN4) in primary neuroblastoma (NB) tumors.
|
28038459 |
2017 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Recent studies have indicated that netrin-4 also participates in the development of nonneural tissues and modulates tumor cell proliferation and tumor metastasis.
|
22496621 |
2012 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Together, these data suggest a potential role for netrin-4 in regulating tumor growth.
|
19094984 |
2009 |
|
Breast Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Some top DEP-responsive genes are novel for breast cancer mortality, such as ABHD14B [for high-vs-low expression, HR 0.36, 95% CI: 0.2-0.5] and TMC4 [HR 0.37, 95% CI: 0.3-0.5]; top hits for MPB (SLC40A1 [HR 0.37, 95% CI: 0.3-0.5] and NTN4 [HR 0.39, 95% CI: 0.3-0.6]) are well-known predictors of breast cancer survival.
|
31593922 |
2019 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
Some top DEP-responsive genes are novel for breast cancer mortality, such as ABHD14B [for high-vs-low expression, HR 0.36, 95% CI: 0.2-0.5] and TMC4 [HR 0.37, 95% CI: 0.3-0.5]; top hits for MPB (SLC40A1 [HR 0.37, 95% CI: 0.3-0.5] and NTN4 [HR 0.39, 95% CI: 0.3-0.6]) are well-known predictors of breast cancer survival.
|
31593922 |
2019 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Nerve guidance factor 4 (Netrin-4, NTN4) is reduced in variety of malignancies and involved in tumor metastasis.
|
27840993 |
2017 |
|
Glioblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
We report here that the suppression of either ITGB4 or NTN4 in glioblastoma cell lines significantly enhances cellular senescence.
|
24265816 |
2013 |
|
Glioblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
EGF/EGFR upregulates and cooperates with Netrin-4 to protect glioblastoma cells from DNA damage-induced senescence.
|
30514230 |
2018 |
|
Adult Glioblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
We report here that the suppression of either ITGB4 or NTN4 in glioblastoma cell lines significantly enhances cellular senescence.
|
24265816 |
2013 |
|
Adult Glioblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
EGF/EGFR upregulates and cooperates with Netrin-4 to protect glioblastoma cells from DNA damage-induced senescence.
|
30514230 |
2018 |