|
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We have recently reported the frequency amplification of the bcl-1 locus in squamous cell carcinomas of head and neck origin, and increased copy number also has been found in some breast adenocarcinomas.
|
2170896 |
1990 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We report here that overexpression of cyclin D1 resulted in abnormal mammary cell proliferation including the development of mammary adenocarcinomas.
|
8208295 |
1994 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
These studies suggest that increased expression of cyclin D1 is an early event in the tumorigenic process of esophageal adenocarcinomas and that the increased expression of this gene might predispose the epithelium to malignant transformation.
|
8781742 |
1996 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Absence of cyclin D1 expression may be a useful prognosticator for shortened survival in primary, resected NSCLCs with particular significance for adenocarcinomas.
|
9815783 |
1997 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
In addition, cyclin D1 amplification is associated with esophageal carcinoma of squamous cell type, being totally absent in adenocarcinomas (p < 0.01).
|
9759649 |
1998 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Paired tumour and normal DNA samples from 26 oesophageal adenocarcinomas and 19 squamous cell carcinomas were analysed by Southern blotting with specific DNA probes for cyclin D1 and MDM-2, and for a control gene (alpha-lactalbumin).
|
10419705 |
1999 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
The SIs of Ki-67 and cyclin D1 in poorly differentiated adenocarcinomas were significantly higher than in the other tumor types.
|
10371338 |
1999 |
|
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Prospective study of cyclin D1 overexpression in Barrett's esophagus: association with increased risk of adenocarcinoma.
|
10944553 |
2000 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Moderately to poorly differentiated adenocarcinomas showed a higher incidence of nuclear cyclin D1 overexpression than papillary to well differentiated carcinomas.
|
10680670 |
2000 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin.
|
12209953 |
2002 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin.
|
12209953 |
2002 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Gastrin-induced gastric adenocarcinoma growth is mediated through cyclin D1.
|
12606305 |
2003 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Increased copy number of the ERBB2 (1 of 22), GATA4 (1 of 22), KRAS (2 of 22), C-MYC (1 of 22), CCNE1 (2 of 22), and CCND1 (2 of 22) genes was also observed in one or more Barrett's adenocarcinomas with HGD.
|
14581353 |
2003 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Cyclin D1 overexpression was found to be present in only 42% of colorectal adenocarcinomas.
|
14592662 |
2003 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Proteins of cyclin D1 were detected by immunohistochemistry in 42 cases of advanced gastric carcinoma with their follow-up data available, 27 cases of early stage carcinoma, 21 cases of gastric adenoma, 22 cases of hyperplastic polyp and 20 cases of normal mucosa adjacent to adenocarcinomas.
|
15378768 |
2004 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Cyclin D1 protein expression was checked in the same group of adenocarcinoma cases.
|
15993030 |
2005 |
|
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Using PCR based restriction fragment length polymorphism and single strand conformational polymorphism, we determined single nucleotide exchanges in the p16 and cyclin D1 genes among 56 esophageal adenocarcinomas (ADC) arising in Barrett's esophagus, 95 cardiac gastric ADC, and in 191 distal gastric ADC.
|
16163549 |
2005 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
LHGDN |
CCND1, EMS1, PIK3CA, and ERBB1 amplifications are uncommon and appear to be late events in the development of ethmoid sinus adenocarcinoma.
|
16815198 |
2006 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The CCND1/GAPDH mRNA levels were significantly higher in adenocarcinoma (35.125 +/- 37.387) than in non-adenocarcinoma (15.2 +/- 24.699; P = .0158), and CCND1/GAPDH mRNA levels were not significantly different among smoking status, sex, or pathologic stage.
|
17922974 |
2007 |
|
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Simultaneous deregulation of p16 and cyclin D1 genes in pancreatic ductal adenocarcinoma: a combined immunohistochemistry and image analysis study based on tissue microarrays.
|
17600882 |
2007 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Association between CCND1 G/A870 polymorphism, allele-specific amplification, cyclin D1 expression, and survival in esophageal and lung carcinoma.
|
19047108 |
2008 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
First, relative expression of both cyclin D1 isoforms was determined in prostate adenocarcinomas.
|
19706803 |
2009 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Further evaluations indicated that phospho-Stat3, phospho-Akt, phospho-nuclear factor κB, cyclin D1, and Ki67 were upregulated in adenocarcinomas from ARR(2)Pb.Stat3C x PTEN(+/-) mice.
|
21390188 |
2011 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Expression of PPARβ/δ mRNA and protein was lower and expression of CYCLIN D1 protein higher in human colon adenocarcinomas compared to matched non-transformed tissue.
|
21400612 |
2011 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We didn't reveal differences in cyclin D1 and galectin-3 expression in SCC and adenocarcinoma patients.
|
22024187 |
2011 |