|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
All 1292 reactive lymph nodes from unselected consecutive surgical specimens of 131 patients without a history of lymphoma obtained over a 3-month period were stained for cyclin D1.
|
22790016 |
2012 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These results indicate that rearrangement of the BCL1 locus may be closely associated with ILL and could be considered as a genotypic marker of this lymphoma subtype.
|
2078513 |
1990 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunophenotypic analysis showed that the lymphoma cells were positive for cyclin D1 (n=16/16), Myc (9/11), and P53 (n=9/9).
|
27776009 |
2017 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
B-cell chronic lymphocytic leukemias (10 of 10), follicular lymphomas (9 of 9), mucosa-associated lymphoid tissue lymphomas (5 of 5) and reactive lymphoid tissues with the exception of normal spleen had no or very low cyclin D1 expression.
|
12231535 |
2002 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These results indicated that positive nuclear staining of lymphoma cells by 5D4 antibody reflects PRAD1/cyclin D1 mRNA expression, and showed that this monoclonal antibody has diagnostic value for differentiating MCL from other types of lymphomas.
|
7591969 |
1995 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, bcl-1 and PRAD1 rearrangement is strongly associated with centrocytic lymphoma, providing a useful molecular marker for classifying this subtype of lymphoma and suggesting an important role for PRAD1 cyclin D1 in the pathogenesis of this neoplasm.
|
1394169 |
1992 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemistry revealed CCND1 to be negative in all lymphomas.
|
11291051 |
2001 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
We identified 25 cases (48 samples) of bcl-1+ and CD5- lymphoma.
|
12162681 |
2002 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The PRAD1 gene, located at 11q13, has been implicated in the pathogenesis of a variety of tumors, including parathyroid adenomas, t(11;14) bearing B-lymphoid tumors (particularly centrocytic lymphomas) where it is highly likely to be the BCL1 oncogene, and possibly in breast carcinomas and squamous cell cancers of the head and neck as well.
|
8426754 |
1993 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The range of cyclin D1 expression among 20 MCLs was substantially higher than that in other lymphomas and reactive lymph nodes.
|
11159766 |
2001 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
CYCLIN D1, a cell-cycle control gene, recently has been shown to be identical to an oncogene alternatively known as BCL-1 and PRAD1 and implicated in centrocytic lymphomas and parathyroid adenomas, respectively.
|
7812927 |
1995 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Current knowledge of cyclin D1 overexpression in malignant lymphomas, with emphasis on its clinicopathologic significance, is reviewed.
|
9234379 |
1997 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A cohort comprising 156 patients with B-cell neoplasms harboring an MYC rearrangement was analyzed with respect to phenotypic presentation, molecular markers (TP53, MYC and ID3) and additional cytogenetic abnormalities (concomitantly occurring BCL2, BCL6 and/or CCND1 rearrangements; double, triple or quadruple hit lymphomas = multiple hit lymphomas).
|
27810071 |
2016 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We managed a peculiar case of lymphoma showing immunohistochemical overexpression of cyclin D1.
|
15239399 |
2004 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
None of the known lymphoma-associated chromosomal changes or rearrangements of the BCL1, BCL2, BCL3, BCL6, and CMYC genes were detected.
|
8547655 |
1996 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We previously showed that p27 expression in MCL, as assessed by immunohistochemistry (IHC), does not show the usual inverse relationship to proliferate seen in most other lymphomas that do not overexpress cyclin D1.
|
12515730 |
2003 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
It was shown that bcl-2 gene rearrangements were exclusively confined to centroblastic-centrocytic lymphomas. bcl-1 rearrangements were found in two cases of chronic lymphocytic leukaemia.
|
1757070 |
1991 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The coincidence of anaplastic and sometimes blast-like morphology of the tumour cells, high proliferation index and a rearranged bcl-1 gene in nearly all cases of anaplastic centrocytic lymphoma support their classification as high-grade malignant variants of centrocytic lymphoma and suggest a possible role for the bcl-1 locus not only in the origin but also in the progression of centrocytic lymphomas.
|
8045522 |
1994 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Its distinction from other lymphomas is important for prognosis and appropriate therapy, but occasional cases may fail to express CCND1 and morphologic simulators may express CD20 and CD5 but not CD23.
|
17934069 |
2008 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Bcl-1/cyclin D1 in malignant lymphoma.
|
9209653 |
1997 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Cyclin D1, an oncogene that has a critical role in G1 progression of the cell cycle, has been observed to be amplified in carcinomas of the breast and head and neck, and translocated in parathyroid adenomas and centrocytic lymphomas.
|
8625145 |
1995 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Cyclin D1 overexpression is a hallmark of mantle cell lymphoma, whereas cyclins D2 and D3 have not been shown to be closely associated with any particular subtype of lymphoma.
|
21790895 |
2011 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The protein synthesis inhibitor silvestrol has potent activity in B-cell leukemias via the mitochondrial pathway of apoptosis, and also reduces cyclin D1 expression in breast cancer and lymphoma cell lines.
|
22791882 |
2012 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Cyclin D1 positive diffuse large B-cell lymphoma is a post-germinal center-type lymphoma without alterations in the CCND1 gene locus.
|
21281227 |
2011 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Rearrangement of bcl-1 has yet to be associated with a specific group of lymphoma.
|
2250191 |
1990 |