|
Abnormality of blood and blood-forming tissues
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Abnormality of bone marrow cell morphology
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Abnormality of the bladder
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormality of the gastrointestinal tract
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormality of the liver
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormality of vitamin B12 metabolism
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Achondroplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Chondrocytes in cartilage biopsies of ACH children were characterized by the presence of growth arrest mediated by STAT activation (both STAT1 and STAT5) and increased expression of p21 and cyclin D1, whereas no expression of either p53 or cyclin D3 could be detected.
|
19802676 |
2009 |
|
Acinar Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Ten patients with high-grade transformation of acinic cell carcinomas: Expression profiling of β-catenin and cyclin D1 is useful.
|
31812438 |
2020 |
|
Acoustic Neuroma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Vestibular schwannomas in both age groups show increased expression of cyclin D1 and cyclin D3.
|
26165351 |
2016 |
|
Acoustic Neuroma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Merlin's subcellular distribution linked cell cycle in VS was analyzed and compared with cyclin D1 expression evaluated with confocal microscopy.
|
17989580 |
2008 |
|
Acoustic Neuroma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Cyclin D1 expression and histopathologic features in vestibular schwannomas.
|
17704717 |
2007 |
|
Acoustic Neuroma
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
The CCND1 Ex4-1G>A variant was associated with increased risk for glioma, and the Ex8+49T>C variant of CCNH was associated with increased risk of glioma and acoustic neuroma.
|
17684142 |
2007 |
|
Acoustic Neuroma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Here we show that merlin deficient tumors exhibited loss of p21, concomitant with elevated CDKs/cyclin D1 levels in sporadic vestibular schwannomas (VS) from clinic patients.
|
20600642 |
2010 |
|
ACTH-Secreting Pituitary Adenoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Tumor tissues from 28 corticotroph adenomas (female 26, male 2, mean age 39.21 ± 10.39 years) were subject to immunohistochemical study using the following antibodies: pituitary tumor-transforming gene 1 (PTTG1), cyclin D1, p16, p27, brahma related-gene 1 (Brg1), and Ki-67.
|
30474823 |
2019 |
|
ACTH-Secreting Pituitary Adenoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Upregulation of CDKN2A and suppression of cyclin D1 gene expressions in ACTH-secreting pituitary adenomas.
|
20616110 |
2010 |
|
Actinic cheilitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Cyclin D1, a target gene of Wnt signaling, was also up-regulated in the AC tumors as compared with the NA samples.
|
24755523 |
2014 |
|
Acute kidney injury
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Acute leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Over expression of cyclin D1 protein has been reported in several solid tumors and certain lymphoid malignancies, but little is known about the involvement of cyclin D1 in acute leukemia.
|
16522546 |
2006 |
|
Acute lymphocytic leukemia
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The AA genotype of CCND1 showed a tendency to increase ALL risk 3.2898-fold compared with the AG + GG genotype (P = .0207).
|
16207592 |
2005 |
|
Acute lymphocytic leukemia
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Homozygosity for CCND1 A allele was associated with ALL patients and was a risk factor for ALL development, while the presence of the A allele, whether in homozygous or heterozygous state was associated with breast cancer cases and was a risk for breast cancer .Homozygosity for CCND1 G allele was associated with the control group.
|
23613410 |
2013 |
|
Acute lymphocytic leukemia
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Cyclin D1-mRNA was detectable in 42 out of 58 patients with de novo ALL (72%) and in 26 out of 28 relapsed patients (93%).
|
10216470 |
1999 |
|
Acute lymphocytic leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
Patients with ALL who were strongly positive for cyclin D1 had a lower probability of remaining in first continuous remission than ALL patients who were negative or weakly positive for this trait.
|
9355972 |
1997 |
|
Acute lymphocytic leukemia
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
This study shows that children with acute lymphoblastic leukaemia (ALL) who are homozygous for the CCND1 A variant have a lower probability of event-free survival (P = 0.006) compared to carriers of the G variant.
|
12972956 |
2003 |
|
Acute lymphocytic leukemia
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
The expression of CD5 and cyclin D1 may need to be routinely determined on ALL cases with mature B-cell phenotype and non-L3 morphology to facilitate timely diagnosis of blastoid MCL and institution of suitable management.
|
12537975 |
2003 |
|
Acute lymphocytic leukemia
|
0.090 |
PosttranslationalModification
|
disease |
BEFREE |
We have demonstrated that WNT5A, a putative tumour suppressor gene in ALL, is silenced by methylation in this disease and that this epigenetic event is associated with upregulation of CYCLIN D1 expression and confers poor prognosis in this group of patients.
|
18032022 |
2007 |