|
Multiple Myeloma
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
|
Multiple Myeloma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
(3) Cyclin D1 overexpression in MM is correlated positively with higher histologic grade and stage.
|
11601138 |
2001 |
|
Multiple Myeloma
|
0.700 |
Biomarker
|
disease |
BEFREE |
14q32 (IgH) translocations are highly prevalent in both sPCL and pPCL (82-87%); in pPCL IgH translocations almost exclusively involve 11q13 (CCND1), supporting a central etiological role, while in sPCL multiple partner oncogenes are involved, including 11q13, 4p16 (FGFR3/MMSET) and 16q23 (MAF), recapitulating MM.
|
18216867 |
2008 |
|
Multiple Myeloma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Cyclin D1 expression is deregulated by chromosome translocation in mantle cell lymphoma and a subset of multiple myeloma.
|
15226187 |
2004 |
|
Multiple Myeloma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Cyclin D1, D2, or D3 expression appears to be increased and/or dysregulated in virtually all MM tumors despite their low proliferative capacity.
|
15755896 |
2005 |
|
Multiple Myeloma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Cyclin D1 mRNA isoforms a and b were expressed in mantle cell lymphoma (MCL) and multiple myeloma (MM).
|
17022831 |
2006 |
|
Multiple Myeloma
|
0.700 |
AlteredExpression
|
disease |
LHGDN |
Cyclin D1 mRNA isoforms a and b were expressed in mantle cell lymphoma (MCL) and multiple myeloma (MM).
|
17022831 |
2006 |
|
Multiple Myeloma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Cyclin D1 is detectable in up to one third of MM patients and plays crucial role in the regulation of G1-S transition in cell cycle.
|
17284370 |
2007 |
|
Multiple Myeloma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Cyclin D1 gene amplification was found in 20% of myeloma patients and was associated with higher percentage of plasma cell infiltration of the bone marrow and increased liability for multiple osteolytic lesions.
|
24468132 |
2014 |
|
Multiple Myeloma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Cyclin D1 is a more prominent driver in AL amyloidosis than in MM, but the links to aggregation of light chains need to be demonstrated.
|
28025584 |
2017 |
|
Multiple Myeloma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
A total of 156 genes, including FGFR3 and CCND1, exhibited highly elevated ("spiked") expression in at least 4 of the 74 MM cases (range, 4-25 spikes).
|
11861292 |
2002 |
|
Multiple Myeloma
|
0.700 |
Biomarker
|
disease |
BEFREE |
A variety of patterns of the IgH deletion were identified by interphase FISH using IgH break-apart and IgH/CCND1 probes in patients with MM and CLL.
|
21272268 |
2011 |
|
Multiple Myeloma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Alterations of the cyclin D1/pRb/p16(INK4A) pathway in multiple myeloma.
|
12200702 |
2002 |
|
Multiple Myeloma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Although cyclin D1 overexpression represents a characteristic feature of all MM cell lines with t(11;14), our results demonstrate aberrant expression of a second putative oncogene in a subset of these cases, due to juxtaposition to IgH enhancers.
|
10753852 |
2000 |
|
Multiple Myeloma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Although cyclin D1 is not expressed in normal hematopoietic cells, one-third of MM tumors ectopically express cyclin D1 in the absence of t(11;14).
|
12846810 |
2003 |
|
Multiple Myeloma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Among recurrent IGH translocations in MM, the frequency of t(4;14) (IGH and FGFR3) or t(11;14) (IGH and CCND1) is greater than the frequency of t(14;16) (IGH and MAF).
|
23460268 |
2013 |
|
Multiple Myeloma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Among the recently discovered myeloma-specific gene alterations associated with chromosomal translocations, cyclin D1/PRAD1/Bcl-1 overexpression caused by t(11;14)(q13;q32) is considered to be the most frequent in myeloma patients and cell lines, and may be a prognostic factor clinically.
|
11552984 |
2001 |
|
Multiple Myeloma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Both methods were applied to isolate VH genes from murine B cell lymphoma (A20 and BCL1), myeloma (NS1) and hybridoma (SP6) cell lines and from freshly isolated human chronic lymphocytic leukemia and lymphoma cells.
|
9324302 |
1997 |
|
Multiple Myeloma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Close relation between 14q32/IGH translocations and chromosome 13 abnormalities in multiple myeloma: a high incidence of 11q13/CCND1 and 16q23/MAF.
|
18274833 |
2008 |
|
Multiple Myeloma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Combination of seliciclib with flavopiridol effectively reduced CCNE1 and CCND1 protein levels, increased subG1 apoptotic fraction and promoted MM cell death in BMSCs co-culture conditions, therefore over-coming stroma-mediated protection.
|
22558078 |
2012 |
|
Multiple Myeloma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Detection of cyclin D1 may be used as a highly specific marker of MCL because it is expressed in virtually all of these tumors, but in only a few reported cases of aggressive variants of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and a small percentage of cases of multiple myeloma.
|
10319380 |
1999 |
|
Multiple Myeloma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Detection of PRAD1 expression may offer an easier alternative to cytogenetic analysis in myeloma and is a potentially useful indicator of a poor prognosis.
|
8610478 |
1995 |
|
Multiple Myeloma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Dysregulation of cyclin D1 by a t(11;14)(q13;q32) translocation occurs in most cases of mantle-cell lymphoma and in approximately 30% of multiple myeloma (MM) tumors in which a 14q32 translocation can be detected.
|
8695815 |
1996 |
|
Multiple Myeloma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Ectopic cyclin D1 overexpression increases chemosensitivity but not cell proliferation in multiple myeloma.
|
19020753 |
2008 |
|
Multiple Myeloma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Finally, a significant proportion of translocation breakpoints in band 11q13 may not be detected by the BCL1 MTC probe in MM, as is true in lymphomas.
|
1415486 |
1992 |