|
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Rearrangements of the bcl-2 gene, associated with the t(14;18)(q32;q21) are present in more than 75% of follicular and 30% of diffuse lymphomas of B-cell origin, suggesting that this translocation plays an important role in B-cell lymphomagenesis.
|
1632463 |
1992 |
|
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This results in a deregulated transcription rate of bcl-2, suggesting a major role of the t(14;18) translocation in lymphomagenesis.
|
1766674 |
1991 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results imply that the bcl-2 gene is preferentially linked to the IgL genes in CLL and could function in leukemogenesis.
|
2106002 |
1990 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The close association between translocation of the proto-oncogene bcl-2 and follicular lymphomas has been well established in Caucasian patients and the de-regulation of bcl-2 has been implicated in follicular lymphomagenesis.
|
2223650 |
1990 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The rearrangement of bcl-2 gene was studied in 56 Japanese B cell lymphoma cases to investigate the contribution of bcl-2 gene to lymphomagenesis in Japan.
|
2511176 |
1989 |
|
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The bcl-2 gene has been identified as a gene directly involved in the consistent chromosome translocation t(14;18), which is found in approximately 90% of human follicular lymphoma cases, and is a prime candidate for the oncogene playing a crucial role in follicular lymphomagenesis.
|
2704746 |
1989 |
|
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data suggest the usefulness of this transgenic system for analysis of lymphomagenesis involving the activated bcl-2 gene.
|
7478600 |
1995 |
|
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The clonality and persistence of BCL2 mutations suggests two specific testable mechanisms of lymphomagenesis.
|
7565870 |
1995 |
|
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In AIDS-related primary brain lymphomas, this correlation between LMP1 and BCL-2 overexpression may have a major implication in lymphomagenesis.
|
7605982 |
1995 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Relevant strains of genetically engineered mice, including bcl-2-Ig and E mu-myc transgenic mice and p53 knockout mice, have been used to prospectively examine the regulation of apoptotic cell death by these genes, individually and in combination, and their contribution to in vivo lymphomagenesis.
|
7621440 |
1995 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic complementation of c-myc and bcl-2 during lymphomagenesis resulted from the suppression of c-myc-associated apoptosis.
|
7698223 |
1995 |
|
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The t(14,18) chromosomal translocation, which results in a fusion messenger RNA containing the entire coding region of BCL-2 and a portion of the immunoglobulin heavy chain gene, is commonly found in follicular lymphoma and appears to play a role in lymphomagenesis by inhibiting cell death.
|
8528964 |
1995 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The usual absence of bcl-2 rearrangement in the HIV-associated B-cell lymphomas suggests that the bcl-2 oncogene in the rearranged B cells of FLH is not cooperating with other oncogenes during HIV lymphomagenesis.
|
8826897 |
1996 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review will attempt to summarize our current understanding regarding the contributions of BCL1 and BCL2 to lymphomagenesis and diagnosis.
|
8852399 |
1995 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate an IGL-mediated rearrangement of an unknown gene at 9q34 that together with BCL2 and MYC might be involved in the lymphomagenesis of the present case of FCCL and perhaps in other cases of non-Hodgkin lymphoma in which t(9;22) is sporadically occurring.
|
9331562 |
1997 |
|
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To evaluate whether this enhancement is the primary role of AML1/ETO in leukemogenesis, effects of over-expression of Bcl-2 in the murine myeloid precursor cell line, 32Dcl3, were examined.
|
10435586 |
1999 |
|
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The sequence of mutations in the process of lymphomagenesis seems to be composed of at least 3 main hits which equip the cells with independence from external mitogenic signals (activation of Ras/Raf), resistance to inducers of apoptosis (activation of Bcl-2) and generation of cellular heterogeneity (deletion of p53) important in tumor progression.
|
10722231 |
2000 |
|
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Together, these data support the importance of anti-apoptotic pathways for BCR/ABL-dependent leukemogenesis and suggest that Bcl-2 expression promotes secondary changes leading to a more aggressive tumor phenotype.(Blood.2000;96:3915-3921)
|
11090078 |
2000 |
|
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We propose that subsequent changes of replication and transcriptional patterns for the translocated BCL2 allele result from this exchange and represent important early steps in lymphomagenesis.
|
11318606 |
2001 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A synergistic interaction of Bcl-2 and c-Myc plays a role in lymphomagenesis in mice and in some patients as well.
|
11431360 |
2001 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
It results in overexpression of the Bcl-2 protein, which inhibits apoptosis and plays a role in lymphomagenesis.
|
11948143 |
2002 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using a mouse model harboring primary, genetically modified myc-driven lymphomas, we show that disruption of apoptosis downstream of p53 by Bcl2 or a dominant-negative caspase 9 confers-like p53 loss-a selective advantage, and completely alleviates pressure to inactivate p53 during lymphomagenesis.
|
12086865 |
2002 |
|
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Although the t(14;18)-induced over-expression of BCL-2 is an important step in lymphomagenesis, this aberration alone is not sufficient to produce malignant lymphoma.
|
12169673 |
2002 |
|
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Finally, these results provide additional evidence that BCL2-IGH translocation measurements could be a measure of acquired genetic instability in relation to genotoxic exposure in a gene directly relevant in term of lymphomagenesis.
|
15026372 |
2004 |
|
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Enforced expression of the antiapoptotic Bcl-2 family protein Mcl-1 promotes lymphomagenesis in the mouse; however, the functional role of Mcl-1 in human B-cell lymphoma remains unclear.
|
15122313 |
2004 |