|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Control of aldosterone secretion in the spontaneously hypertensive rat.
|
1149188 |
1975 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
In six additional patients with high renin levels induced by prior sodium depletion (10 mEq/day sodium diet), clonidine did not reduce blood pressure or renin, thus indicating that the suppressive action of this agent on renin pressor mechanisms occurs only in patients whose elevated renin levels are intrinsic to hypertension and unrelated to sodium depletion.
|
998518 |
1976 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Reduced plasma renin activity in essential hypertension: effects of blood pressure, age and sodium.
|
1071603 |
1976 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
High blood pressure and elevated plasma renin activity have been normalized with a unilateral revascularization in the elder patient, and with the treatment of propranolol in the younger one.
|
951017 |
1976 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Low renin hypertension. A distinct entity.
|
62162 |
1976 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Further investigation of a family with normaldosteronemic hyperpotassemia and low-renin hypertension showed seven members from three generations, who ranged in age from 4 to 56 years, to be affected.
|
718349 |
1978 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Hypertension and hyperpotassemia that were accompanied by normal plasma aldosterone and low renin levels and were responsive to chlorothiazide administration were found in a 29-year-old patient and two decades later in his 21-year-old son.
|
718348 |
1978 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Estrogens and hypertension: effect of discontinuing estrogens on blood pressure, exchangeable sodium, and the renin-aldosterone system.
|
45830 |
1979 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Lateralization of renal vein renins and exaggerated hyperreninemia following captopril suggested renin-mediated hypertension in 1 case, which responded well to nephrectomy.
|
6381767 |
1984 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Calf muscle haemodynamics and the renin-angiotensin-aldosterone system in normotensive subjects with a familial predisposition to hypertension: changes during increased salt intake.
|
6397530 |
1984 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Comparison of the kidney function of normotensive subjects likely to develop hypertension with that of matched controls resistant to hypertension showed, in the former, a higher glomerular filtration rate (GFR), greater tubular reabsorption, larger 24-h urinary output, larger fraction of cardiac output to the kidney, and lower plasma renin activity.
|
6204136 |
1984 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Changes in blood pressure, pulse rate, and plasma catecholamines, renin activity, cortisol, and calcium were studied in 16 normotensive subjects (eight with a family history of hypertension) for 5 hours following ingestion of alcohol-free and alcohol-loaded beer.
|
3522422 |
1986 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Furthermore, an association of any renin allele with hypertension was not apparent.
|
3319438 |
1987 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
In subjects with a family history of hypertension, the renal vascular response to diltiazem was enhanced (p less than 0.01) despite similar values of plasma renin activity, angiotensin II concentration, and sodium excretion.
|
2435657 |
1987 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
After changing to the high sodium diet, body weight, exchangeable sodium, and sodium clearance increased and renin decreased significantly (P less than 0.05) and to a similar extent in the two groups; systolic blood pressure increased only in subjects with a family history of hypertension.
|
3429871 |
1987 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
In a preliminary report, a study of the TaqI polymorphism of the human renin gene did not reveal a significant difference between hypertensive patients with a family history of hypertension and normotensive controls.
|
2467101 |
1988 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Body sodium, the cardiovascular pressor reactivity to infused noradrenaline or angiotensin II, plasma levels of noradrenaline, adrenalin, renin, angiotensin II, aldosterone and atrial natriuretic peptide were measured on a low or high sodium diet in 10 normotensive young subjects without and 13 normotensive subjects with familial predisposition to hypertension.
|
3065505 |
1988 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
This newly identified form of endocrine hypertension is strongly linked to excessive body weight but is associated with alterations in the renin-aldosterone and sympathetic nervous systems that are distinct from those encountered in obesity-related hypertension in the general population.
|
2848415 |
1988 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
These results suggested that schoolchildren with a family history of hypertension might have an enhanced renin-aldosterone (R-A) system, resulting in elevation of blood pressure.
|
3045203 |
1988 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Although we found no genetic linkage in this set of study subjects, the characterization of the restriction fragment length polymorphisms for the renin gene may be useful in future studies of other selected pedigrees for the presence of one or more of these to be a genetic marker in hypertension.
|
2573574 |
1989 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Blood pressure values were lower in the former and, conversely, Counter "+" hypertensives showed a higher prevalence of moderate or severe hypertension (65.5% vs. 32.6%; P = 0.0059) and higher values of stimulated plasma renin activity (1.63 +/- 0.52 vs. 0.81 +/- 0.15; P = 0.0443).
|
2811053 |
1989 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
The increased renin release, perhaps due to renal ischemia caused by cyst expansion, probably contributes to the early development of hypertension in polycystic kidney disease.
|
2215576 |
1990 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
She presented all the features of the classical severe form of the disease: complete female phenotype; hypertension; hypokalemia; elevated levels of plasma progesterone, 11-deoxycorticosterone, corticosterone (B), and ACTH; and suppression of renin and aldosterone production.
|
2166072 |
1990 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
This review discusses the impact of the availability of these clones in three clinically relevant areas--the role of the renin-angiotensin system in hypertension, the role of tissue renin-angiotensin systems, and the development of renin inhibitors.
|
1725015 |
1991 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Since the renin gene is a member of a conserved synteny group that in humans spans chromosome 1q21.3-32.3 and includes the gene for antithrombin III (AT3), we used linkage studies to examine the relationship between alleles of AT3 and hypertension in a family having 10 affected members.2.
|
1676620 |
1991 |