|
Diverticulitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Colonic specimens of adult controls and patients with diverticulitis were subjected to quantitative polymerase chain reaction for Phox2b and dual-label immunochemistry for Phox2b and the neuronal markers RET and tyrosine hydroxylase or the glial marker S100β.
|
31019703 |
2019 |
|
Patent ductus arteriosus
|
0.010 |
Biomarker
|
disease |
BEFREE |
To assess the role of RET as a co-driver of PDA, we generated a novel triple mutant transgenic mouse based on the cre-activated p53<sup>R172H</sup> gene and a constitutively active RET <sup>M919T</sup> mutant (PRC).
|
30515799 |
2019 |
|
Histiocytosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we uncovered activating mutations in CSF1R and rearrangements in RET and ALK that conferred dramatic responses to selective inhibition of RET (selpercatinib) and crizotinib, respectively, in patients with histiocytosis.
|
31768065 |
2019 |
|
Acinar Cell Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We postulated that given its unique molecular profile, RET gene rearrangements may be common in acinar cell carcinomas.
|
31558784 |
2019 |
|
Metastatic melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Genetic IL4I1 invalidation increases the number of tumor-associated B cells and delays development of spontaneous metastatic melanoma in mice that are transgenic for the RET oncogene, without impairing tumor-specific antibody response.
|
31679193 |
2019 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data support RET as a potential target and GPNMB as a diagnostic marker for TFE3-RCC.
|
31043488 |
2019 |
|
Inflammatory Myofibroblastic Tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
The IMTs were classified as the ALK (n=29), ROS1 (n=2), NTRK3 (n=2), RET (n=0), and 'quadruple-negative' (n=7) genotypes by molecular analyses.
|
31578734 |
2019 |
|
Secretory breast carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Advances in molecular profiling of SC have led to the discovery of novel fusion partners such as RET and now MAML3.
|
30130630 |
2019 |
|
Hyperganglionosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mice conditionally expressing RET(C618F) mutation display C cell hyperplasia and hyperganglionosis of the enteric nervous system.
|
30884088 |
2019 |
|
Irritable bowel syndrome with diarrhea
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We suggest that modulating the cholinergic control of the colon via a RET inhibitor may represent a novel target for the treatment of intestinal disorders associated with increased secretion and accelerated GI transit such as irritable bowel syndrome with diarrhea (IBS-D).
|
30311722 |
2019 |
|
Histiocytic syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we uncovered activating mutations in CSF1R and rearrangements in RET and ALK that conferred dramatic responses to selective inhibition of RET (selpercatinib) and crizotinib, respectively, in patients with histiocytosis.
|
31768065 |
2019 |
|
Ewings sarcoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Ewing sarcoma (ES), a common pediatric primary bone neoplasm, has a well-defined genomic landscape with various predisposing genomic elements including TP53, PMS2 and RET.
|
31072725 |
2019 |
|
Tumor Initiation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Strikingly, serial in vivo re-transplantation assays demonstrated a marked reduction in tumor initiation ability of recurrent MB cells upon re-transplantation of PTC-028-treated cells into secondary recipient mouse brains.
|
30348991 |
2019 |
|
invasive cancer
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Study of human PDA specimens and Pdx-1-Cre/Kras<sup>G12D</sup> /p53<sup>R172H</sup> (KPC) mice revealed that RET is upregulated during pancreas tumorigenesis, from inception through precursor lesions, to invasive cancer.
|
30515799 |
2019 |
|
Poorly differentiated carcinoma
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Histology was reviewed, and the patients were divided in the following three groups: poorly differentiated carcinoma [PDTC; group 1 (n = 27)]; papillary thyroid carcinoma with PDA [PTC with PDA; group 2 (n = 27)]; and follicular thyroid carcinoma with PDA [FTC with PDA; group 3 (n = 88)].
|
30673845 |
2019 |
|
Ductal Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The presence of tumor-type-specific NCOA4-RET or TRIM27-RET translocations in a subset of widely invasive carcinomas with intercalated duct-like immunoprofiles suggests that a recharacterization of IC including its redesignation as "intercalated duct carcinoma, invasive or noninvasive" may be appropriate.
|
31162284 |
2019 |
|
Spindle Cell Neoplasm
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
S100 and CD34 positive spindle cell tumor with prominent perivascular hyalinization and a novel NCOA4-RET fusion.
|
30938880 |
2019 |
|
Cardiomyopathy, Familial Idiopathic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
57% IDCs (16 LG-IDCs, 1 HG-IDC) showed RET rearrangements, including NCOA4-RET (8 intercalated, 2 unclassifiable IDCs) and TRIM27-RET fusions (2 mixed IDCs).
|
31697865 |
2019 |
|
Ductal Breast Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The presence of tumor-type-specific NCOA4-RET or TRIM27-RET translocations in a subset of widely invasive carcinomas with intercalated duct-like immunoprofiles suggests that a recharacterization of IC including its redesignation as "intercalated duct carcinoma, invasive or noninvasive" may be appropriate.
|
31162284 |
2019 |
|
Insulin-Like Growth Factor I Deficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Results show that the mere IGF-1 deficiency seems to be responsible for an altered expression of genes coding for neurotrophic factors (particularly ciliary neurotrophic factor and mesencephalic astrocyte-derived neurotrophic factor), their receptors and signaling pathways (specially RET).
|
30708048 |
2019 |
|
Unspecified visual loss
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
A 48-year-old patient affected by MEN2B complained of progressive visual loss in his right eye and severe red, dry and itchy eyes.
|
31205161 |
2019 |
|
PATENT DUCTUS ARTERIOSUS 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
To assess the role of RET as a co-driver of PDA, we generated a novel triple mutant transgenic mouse based on the cre-activated p53<sup>R172H</sup> gene and a constitutively active RET <sup>M919T</sup> mutant (PRC).
|
30515799 |
2019 |
|
Triple-Negative Breast Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Using targeted sequencing, we detected somatic mutation-related discordant breast cancer including the VHL gene in the HR+/HER2- group (31% in concordant group, 0% in discordant group, p=0.03) and the IDH and RET genes (7% vs. 12%, p=0.02 and 0% vs. 25%, p=0.02, respectively) in the TNBC group.
|
30189722 |
2019 |
|
Amyloidosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Herein, electrochemiluminescence resonance energy transfer (ECL-RET) was employed to determine Aβ concentration, which can be attributed to the quenching effect from RET between Ru(bpy)<sub>3</sub><sup>2+</sup> and gold nanorods (GNRs) acting as ECL-RET electron donor and acceptor, respectively.
|
28938186 |
2018 |
|
Hyperparathyroidism, Secondary
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RET was affected in HPT1 hyperplasia, whereas CaSR and VDR transcripts were downregulated in HPT2 hyperplastic PG tissue.
|
29659895 |
2018 |