|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The molecular genetic screening for MEN2-associated RET germline mutations should be carried out in all patients with an apparently sporadic medullary thyroid carcinoma or pheochromocytoma.
|
15630638 |
2004 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
RET exon 11 (G691S) polymorphism is significantly more frequent in sporadic medullary thyroid carcinoma than in the general population.
|
15240649 |
2004 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The newly detected mutations in the RET proto-oncogene in exon 16 as a cause of sporadic medullary thyroid carcinoma.
|
14618242 |
2003 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A founding locus within the RET proto-oncogene may account for a large proportion of apparently sporadic Hirschsprung disease and a subset of cases of sporadic medullary thyroid carcinoma.
|
12474140 |
2003 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
However, according to the published overrepresentation of the RET polymorphism S836S in patients suffering from apparent sporadic medullary thyroid carcinoma, it is conceivable that it also plays a role in multiglandular endocrine disease.
|
12410354 |
2002 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Because RET variants seem to be associated with MTC, it is plausible that variants in genes encoding for RET coreceptors may play a role in the pathogenesis of sMTC.
|
12490080 |
2002 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Prognostic value of codon 918 (ATG-->ACG) RET proto-oncogene mutations in sporadic medullary thyroid carcinoma.
|
11241313 |
2001 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, familial medullary thyroid carcinoma with noncysteine RET mutations are not infrequent and are overrepresented in presumed sporadic medullary thyroid carcinoma, suggesting that RET analysis should routinely be extended to exons 13, 14, and 15.
|
11502806 |
2001 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Germline sequence variant S836S in the RET proto-oncogene is associated with low level predisposition to sporadic medullary thyroid carcinoma in the Spanish population.
|
11589684 |
2001 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Over-representation of a germline variant in the gene encoding RET co-receptor GFRalpha-1 but not GFRalpha-2 or GFRalpha-3 in cases with sporadic medullary thyroid carcinoma.
|
11360200 |
2001 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Some cases of sporadic medullary thyroid carcinoma (MTC) have also been reported to have mutations in the RET gene.
|
11429053 |
2001 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Screening for somatic mutations in RET exons 16, 13 and 15 was performed in a patient with a sporadic medullary thyroid carcinoma.
|
10822219 |
2000 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Unilateral surgery supported by germline RET oncogene mutation analysis in patients with sporadic medullary thyroid carcinoma.
|
11038208 |
2000 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
Biomarker
|
disease |
BEFREE |
Activating mutations of the RET proto-oncogene were found in multiple endocrine neoplasia (MEN) 2 and in sporadic medullary thyroid carcinoma and pheochromocytoma of neuroendocrine origin.
|
10426588 |
1999 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
No correlation between RET immunostaining and the codon 918 mutation in sporadic medullary thyroid carcinoma.
|
10367632 |
1999 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To investigate whether other RET sequence variants may be associated with or predispose to the development of sporadic medullary thyroid carcinoma, we analysed genomic DNA from the germline and corresponding tumour from 50 patients to identify RET sequence variants.
|
10022819 |
1999 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Several mutations were identified in the kinase domain of the RET proto-oncogene in patients with multiple endocrine neoplasia (MEN) 2B, familial medullary thyroid carcinoma (FMTC) or sporadic medullary thyroid carcinoma.
|
10445857 |
1999 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Some cases of sporadic medullary thyroid carcinoma (sporadic MTC) are reported to have specific codon 918, 883 and 768 mutations of the RET gene in tumor tissues.
|
9617347 |
1998 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
RET protooncogene mutations in patients with apparently sporadic medullary thyroid carcinoma.
|
9747064 |
1998 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
Biomarker
|
disease |
BEFREE |
Mutation of the RET proto-oncogene is correlated with RET immunostaining in subpopulations of cells in sporadic medullary thyroid carcinoma.
|
9851769 |
1998 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The presence of germline and somatic mutations in the RET proto-oncogene (RET) in patients with hereditary and sporadic medullary thyroid carcinoma (MTC) may have important ramifications for patient management.
|
9824378 |
1998 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Mutation of RET proto-oncogene in Japanese patients with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma.
|
9447290 |
1997 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Somatic RET mutations have been identified in a variable proportion (about 30-70%) of sporadic Medullary Thyroid Carcinoma (MTC) cases.
|
9191060 |
1997 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Germ-like and somatic mutations in the RET proto-oncogene are associated with inherited and sporadic medullary thyroid carcinoma (MTC).
|
9223675 |
1997 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A complex nine base pair deletion in RET exon 11 common in sporadic medullary thyroid carcinoma.
|
9160884 |
1997 |