|
Chronic Fatigue Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Identification of actin network proteins, talin-1 and filamin-A, in circulating extracellular vesicles as blood biomarkers for human myalgic encephalomyelitis/chronic fatigue syndrome.
|
31759091 |
2020 |
|
Cardiac Arrest
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although there was functional recovery with normalization of GFR two weeks after CA/CPR, deposition of tubulointerstitial matrix proteins α-smooth muscle actin and fibrillin-1 progressed, along with a significantly reduced mean GFR (623 in sham vs. 409 μL/min/100g in CA/CPR animals), proteinuria, increased tissue transforming growth factor-β, and fibrosis establishing the development of CKD seven weeks after CA/CPR.
|
31623859 |
2020 |
|
Jaundice, Obstructive
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
All these data demonstrated that p38 MAPK-pHsp27 mediates vascular hyporesponsiveness in rats with obstructive jaundice by modulating the expression level of pHsp27 and F-actin, and that inhibition of p38 MAPK signaling could remodel the vascular activity.
|
31810142 |
2020 |
|
Marfan Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MFS-VSMC proteomic profile diverged from that of WT-VSMC particularly regarding lower expression of actin cytoskeleton-regulatory proteins.
|
31678158 |
2020 |
|
Epstein-Barr Virus Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
From two independent proteomic analyses using circulating EVs from ME/CFS, healthy controls, idiopathic chronic fatigue, and depression, proteins identified from ME/CFS patients are involved in focal adhesion, actin skeletal regulation, PI3K-Akt signaling pathway, and Epstein-Barr virus infection.
|
31759091 |
2020 |
|
Periosteal Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Alpha-smooth muscle actin (αSMA) is a marker of early osteoprogenitor cells in the periosteum, and we hypothesized that the new osteoblasts that are activated by loading could originate from αSMA-expressing cells.
|
31673746 |
2020 |
|
Rhinovirus infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, we identify Arpin as a central actin regulator during phagocytosis that it is targeted by human rhinovirus 16, allowing the virus to perturb bacterial internalisation and phagocytosis in macrophages.
|
31721415 |
2020 |
|
Ischemic stroke
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
ACTB rs852426 was significantly associated with alcohol consumption on stroke risk, and the expression of ACTB mRNA in IS who had a drinking habit was significantly down-regulated.
|
31327802 |
2020 |
|
ACTIVATED PI3K-DELTA SYNDROME
|
0.010 |
Biomarker
|
disease |
BEFREE |
EBV-transformed lymphoblastoid cells (EBV-LCLs) from patients with APDS exhibit increased polymerized actin and increased apoptosis, suggesting a contribution of impaired actin dynamics to this disease.
|
31760094 |
2020 |
|
Signet-ring stromal tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
The immunohistochemical profile-positive steroidogenic factor 1, calretinin, and smooth muscle actin, and negative epithelial membrane antigen-supported the diagnosis of SRST.
|
30676431 |
2020 |
|
Immunosuppression
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RNA interference (RNAi) of SePGDS expression resulted in immunosuppression of cellular immune responses by suppressing the expression of actin polymerization-associated genes.
|
31794733 |
2020 |
|
Alcohol Use Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data show that Rac1 and cofilin activity are key to determining the rate of acquisition of alcohol preference, revealing a critical role of actin dynamics regulation in the development of voluntary self-administration in <i>Drosophila</i><b>SIGNIFICANCE STATEMENT</b> The risks for developing an alcohol use disorder (AUD) are strongly determined by genetic factors.
|
31558618 |
2019 |
|
Ameloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
All three factors were heterogeneously detected in ameloblastoma samples (α-SMA, n=71/76, 93.4%; osteonectin, n=72/76, 94.7%; N-cadherin, n=24/76, 31.6%).
|
31262562 |
2019 |
|
Bloom Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results showed that SAC dose-dependently reduced the infiltration of inflammatory cells, pulmonary lesions and collagen deposition in BLM treated mice with downregulated mRNA expression levels of fibrotic genes including alpha smooth muscle actin (α-SMA), fibronectin, collagen I and collagen III as well as the protein level of α-SMA.
|
30928090 |
2019 |
|
Bone neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
A subpopulation of osteoblasts was identified in the bone tumor microenvironment in vivo of both humans and mice with bone metastatic breast cancer that express RUNX2/OCN/OPN but is negative for IL-6 and alpha-smooth muscle actin.
|
30813947 |
2019 |
|
Borna Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Intracellular dynamics of actin affects Borna disease virus replication in the nucleus.
|
30769121 |
2019 |
|
Carcinosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nevertheless, immunohistochemistry is the gold standard for the diagnosis of carcinosarcomas, since it has been demonstrated that CEA, EMA, pancreatin, chromogranin A, CD56 and synaptophysin staining are highly specific markers for the carcinomatous components, while desmin, vimentin and smooth muscle/sarcomeric actin show affinity for the sarcomatous elements.
|
30570870 |
2019 |
|
Cocaine Abuse
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Cytoskeletal changes initiated following cocaine abuse are regulated by the Rho family of GTPases with significant downstream activity in key actin binding proteins.
|
30623590 |
2019 |
|
Conn Adenoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We show that RHOC, a GTPase controlling actin organization in response to extracellular stimuli, is upregulated in APA and promotes expression of the aldosterone synthase gene CYP11B2.
|
30580688 |
2019 |
|
Dehydration
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Periodic acid-Schiff and alpha-smooth muscle actin (α-SMA) staining before dehydration and after rehydration were performed to determine the presence of keratocytes and expression of α-SMA.
|
30681513 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present study aims to explore whether the common variants at the <i>ACTB</i> gene contribute to diabetic kidney disease (DKD) susceptibility in patients with type 2 diabetes mellitus (T2DM).
|
31396261 |
2019 |
|
Eosinophilia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Eosinophils increased α-smooth muscle actin expression in airway epithelial cells, which was attenuated by SPD treatment.
|
29663427 |
2019 |
|
Hand, Foot and Mouth Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
In summary, Our results showed that SAA and human β-actin (ACTB) may be served as a potential biomarker of the clinical diagnosis of severe HFMD.
|
30817906 |
2019 |
|
Hirschsprung Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study of the Actin G2 gene in patients with Hirschsprung disease explores a possible molecular basis abnormal muscle function and post-surgical pseudo-obstruction in a group of patients.
|
30885557 |
2019 |
|
Lymphohistiocytosis, Hemophagocytic
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Abbreviations</b> ACTB: actin, beta; CTSB: cathepsin B; EEA1: early endosome antigen 1; ESCRT: endosomal sorting complex required for transport; FHL3: familial hemophagocytic; lymphohistiocytosis type 3; HEX: hexosaminidase; HLH: hemophagocytic lymphohistiocytosis; LSD: lysosomal storage disorder; MEF: mouse embryonic fibroblast; SEM: standard errors of the mean; SNARE: soluble n-ethylmaleimide-sensitive-factor attachment receptor; STX: syntaxin; SYT7: synaptotagmin VII; TFE3: transcription factor E3; TFEB: transcription factor EB; TIRF: total internal reflection fluorescence ULK1: unc-51 like kinase 1; UNC13D: unc-13 homolog d; VAMP: vesicle-associate membrane protein; WT: wild-type.
|
30892133 |
2019 |