|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
BCL2/MYC DH lymphomas constituted the majority of these DH lymphomas (17 cases; 77%), followed by BCL6/MYC (2 cases; 9%) lymphomas.
|
26224092 |
2015 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
High-grade B-cell lymphomas (HGBLs) with MYC and BCL2 and/or BCL6 rearrangements, so-called "double-hit" lymphomas (HGBL-DH), are aggressive lymphomas that form a separate provisional entity in the 2016 revised World Health Organization Classification of Lymphoid Tumors.
|
27821509 |
2017 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Lymphomas with MYC and either BLC2 or BCL6 rearrangements or MYC and BCL-2 protein overexpression, classified as double-hit (DHL) or double-expressor (DEL) lymphomas, respectively, are associated with poorer response to standard immunochemotherapy.
|
29722657 |
2018 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Rearrangement of the bcl-6 gene correlated with a favorable clinical outcome in DLLC and may thus serve as a prognostic marker in patients with this form of malignant lymphoma.
|
8208268 |
1994 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The median cytogenetic complexity score was 2.5 (range, 0 to 14) in 14 evaluable mature aggressive lymphomas with an immunoglobulin gene partner for MYC in 9/14 and for BCL6 in 7/14 cases.
|
23348205 |
2013 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Rearrangement of the BCL6 gene in B-cell lymphoid neoplasms: comparison with lymphomas associated with BCL2 rearrangement.
|
8703825 |
1996 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Bcl-6 p53 mutations in lymphomas carrying the bcl-2/Jh rearrangement.
|
12217802 |
2002 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Therefore, identification of the normal B cell subset with the most similar gene expression pattern to a particular type of B cell lymphoma has been instrumental to deduce the precise cell of origin of lymphomas.We present here protocols to analyze human B cell lymphomas for a potential origin from GC B cells by determining the presence of mutations in rearranged IgV genes and the BCL6 gene, and by comparing the gene expression pattern of lymphoma cells with those of normal B cell subsets by genechip or RNA-sequencing analysis.
|
28589362 |
2017 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Double/triple-hit lymphomas (DHL/THL) account for 5-10% of diffuse large B cell lymphoma (DLBCL) with rearrangement of MYC and BCL2 and/or BCL6 resulting in MYC overexpression.
|
31288832 |
2019 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Twelve B-cell non-Hodgkin's lymphomas with BCL6/LAZ3 rearrangement selected from a series of 30 lymphomas with cytogenetically detectable 3qter abnormalities were characterized at the histological, clinical, and cytogenetic levels, including fluorescence in situ hybridization (FISH) analysis, which was performed in all cases but one.
|
8527378 |
1995 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Recurrent chromosomal translocations in malignant lymphomas most commonly involve 18q21(bcl-2), 8q24 (c-myc) and 3q27 (bcl-6), with an incidence of 27%, 11% and 6%, respectively.
|
10233417 |
1999 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Here we report that PEL is associated with a high frequency of mutations of BCL6 5' noncoding regions, and we identify karyotypic abnormalities that may be recurrently involved in these lymphomas.
|
9892104 |
1999 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Genetic modifications of the BCL6 gene in lymphoma include translocations, deletions, and somatic mutations (SM) of the 5' noncoding region.
|
16094416 |
2005 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Mutations of BCL-6 proto-oncogene, a zinc finger transcription factor implicated in lymphoma development, represent a histogenetic marker of B cell transit through the germinal center (GC) and occur frequently in B cell malignancies derived from GC or post-GC B cells.
|
10803511 |
2000 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Aggressive lymphomas with MYC and BCL2 and/or BCL6 translocations ("double hit" lymphomas, DHL) represent a distinct diagnostic category in the updated World Health Organization (WHO) classification.
|
29629947 |
2019 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Analysis of the bcl6 noncoding first exon showed somatic mutations in two of four cases analyzed, as would be expected in lymphoma deriving from the germinal center.
|
11420458 |
2001 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
In this review, we summarize two sessions dedicated to "high-grade B cell lymphomas, with MYC and BCL2 and/or BCL6 rearrangements (so-called double/triple-hit lymphomas)" and "high-grade B cell lymphomas, NOS" as defined in the 2016 update of the WHO lymphoma classification, Burkitt lymphoma and related neoplasms, and terminally differentiated aggressive B cell lymphomas.
|
28844114 |
2017 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Follicular lymphoma without t(14;18) and with BCL-6 rearrangement: a lymphoma subtype with distinct pathological, molecular and clinical characteristics.
|
12399977 |
2002 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Hypermutations at the E1.11 segment of bcl-6 gene were detectable in 16/22 (73%) primary gastric and 4/18 (22%) primary nodal lymphoma (P<0.01).
|
9401082 |
1997 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Conversely, mutations of the 5' noncoding region of BCL-6 occur at sustained frequency throughout the clinico-pathologic spectrum of AIDS-NHL and represent the most common genetic alteration presently detectable in these lymphomas.
|
9720713 |
1998 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Lymphomas with BCL6- and BCL2-translocations were very similar to t(14;18)-positive lymphomas without BCL6-translocations.
|
20032416 |
2009 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
To evaluate this further, we compared mutations occurring within the major mutation cluster region of the translocated and untranslocated BCL-6 alleles in 7 t(3;14)(q27;14q32) lymphomas.
|
12775568 |
2003 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The frequent BCL6 mutation in these tumors is consistent with our previous observation of hypermutation of the 5' noncoding region of the gene in lymphomas arising in the germinal-center B-cells.
|
9824205 |
1998 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
There were 47 DTHLs, 36 cases with MYC and BCL2 and/or BCL6 extra signals (ES) and/or rearrangements (ES group, excludes DTHLs), 9 with MYC rearrangements only (single-hit lymphoma), and 95 with no MYC abnormalities (NM).
|
28614202 |
2017 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The heterogeneity in partner sites is distinct from other lymphoma subgroups and may suggest that the genetic events are not uniform among patients with BCL6 rearrangements.
|
9402330 |
1997 |