|
Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
BCL6 is overexpressed in the majority of patients with aggressive diffuse large B-cell lymphoma (DLBCL), the most common lymphoma in adulthood, and transgenic mice constitutively expressing BCL6 in B cells develop DLBCLs similar to the human disease.
|
22113614 |
2012 |
|
Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Immunophenotypic and genotypic markers used to suggest a FCC origin for a lymphoma (bcl-6 and CD10 expression, lack of CD138 expression, bcl-2 rearrangements [R]) or to subdivide DLBCL (bcl-2 expression, bcl-6 R) were therefore investigated in 22 FL and 44 DLBCL using paraffin section immunostains and Southern blot/polymerase chain reaction analysis.
|
11106080 |
2000 |
|
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, 50% of the BCL-6 rearrangement positive lymphoma cases had coexisting gene rearrangements involving all of the aforementioned gene loci.
|
9184180 |
1997 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Reasoning that disruption of POZ domain-mediated interactions may be an effective route to antagonizing the effects of BCL-6 in lymphoma, we screened a library for peptide aptamers that specifically bind to BCL-6 POZ and not the POZ domains of related proteins and describe here the first of these reagents, Apt48.
|
16331266 |
2006 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chromosomal alterations involving 3q27 seem to be responsible for this increased Bcl6 expression, which needs to be considered when Bcl6 is used in lymphoma diagnosis.
|
15252312 |
2004 |
|
Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here we show that the murine lymphoma cell line A20 resembles primary GCB cells in expression of GC-specific surface markers and the master transcription factor BCL6 and may serve as a useful system to model certain GCB cell behaviors in vitro.
|
29154209 |
2018 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
BCL6 as a therapeutic target for lymphoma.
|
29262721 |
2018 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Double-color FISH with IgH (Y6) and BCL6 (cosB5-1) showed fusion of BCL6 and IgH genes on der(3)t(3;14) in all nine patients, suggesting that der(3) may play a critical role in the development of lymphoma carrying complex as well as standard t(3;14) translocations.
|
9398863 |
1997 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A significant association was seen between lymphoma stage and BCL6 (p=0.045) but not MUM1 expression (p=0.09).
|
25640395 |
2015 |
|
Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Somatic hypermutation of the BCL6 gene and its expression in lymphoma represent specific markers for B-cell transit through the germinal center.
|
15377470 |
2004 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several experiments and mouse models mimicking BCL6 translocation occurring in human lymphoma have demonstrated the oncogenic role of BCL6 and constitute a rational to consider BCL6 as a new therapeutic target in NHL.
|
16815642 |
2007 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Following a broad panel of immunohistochemical stains, the strong positive staining of the spindle cells for LCA (CD45), CD20, and Bcl-6 confirmed the diagnosis of follicle center cell lymphoma.
|
31693188 |
2020 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, tandem targeting of the overlapping BCL6 and p53 transcriptional programs can correct aberrant survival pathways in DLBCL and might provide an effective therapeutic approach to lymphoma therapy.
|
18451163 |
2008 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We speculate that the poor outcome of primary adrenal lymphoma might be related to the bulky tumor size at presentation, non-germinal center B-cell phenotype, and frequent BCL-6 gene rearrangement.
|
19525926 |
2009 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
They were subclassified using CD10, mum-1, bcl-6 as germinal center B-cell like (GCB) lymphoma (30%) and non-GCB lymphoma (70%).
|
19298719 |
2009 |
|
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Follicular lymphoma without t(14;18) and with BCL-6 rearrangement: a lymphoma subtype with distinct pathological, molecular and clinical characteristics.
|
12399977 |
2002 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Simple karyotyping revealed key translocations involving MYC, BCL2, and BCL6 that have impacted lymphoma classification in the World Health Organization classification scheme.
|
30213388 |
2018 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our studies identify PRMT5 as a novel regulator of the GC reaction and highlight the mechanistic rationale of cotargeting PRMT5 and BCL6 in lymphoma.
|
30082494 |
2018 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data confirm ITM2B as a target of BCL6 repression in lymphoma.
|
25557390 |
2015 |
|
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There were 47 DTHLs, 36 cases with MYC and BCL2 and/or BCL6 extra signals (ES) and/or rearrangements (ES group, excludes DTHLs), 9 with MYC rearrangements only (single-hit lymphoma), and 95 with no MYC abnormalities (NM).
|
28614202 |
2017 |
|
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic modifications of the BCL6 gene in lymphoma include translocations, deletions, and somatic mutations (SM) of the 5' noncoding region.
|
16094416 |
2005 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus BCL6 is considered to be involved in germinal center (GC)-derived lymphoma.
|
31063496 |
2019 |
|
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Analysis of the bcl6 noncoding first exon showed somatic mutations in two of four cases analyzed, as would be expected in lymphoma deriving from the germinal center.
|
11420458 |
2001 |
|
Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Hypermethylation of the Bcl6 locus followed by BCL6 upregulation was thought to be the key event for lymphoma development in mice.
|
27921272 |
2017 |
|
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations of BCL-6 proto-oncogene, a zinc finger transcription factor implicated in lymphoma development, represent a histogenetic marker of B cell transit through the germinal center (GC) and occur frequently in B cell malignancies derived from GC or post-GC B cells.
|
10803511 |
2000 |