|
Colorectal Carcinoma
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Meckel-Gruber syndrome
|
0.100 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
Polycystic Kidney, Autosomal Dominant
|
0.010 |
Biomarker
|
disease |
BEFREE |
At the same time, sec6 and sec8, components of a complex critical for basolateral cargo delivery normally arrayed at the apico-lateral apex, were depleted from the ADPKD cell plasma membrane.
|
10747091 |
2000 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We propose that SEC8L1, which encodes a component of the exocyst complex, is a candidate susceptibility gene for RA in the Japanese population.
|
15880602 |
2005 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart Study.
|
18498660 |
2008 |
|
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Exocyst complex component Sec8: a presumed component in the progression of human oral squamous-cell carcinoma by secretion of matrix metalloproteinases.
|
23207790 |
2013 |
|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Sec8 protein expression in primary OSCCs also was significantly (p < 0.05) greater than in normal counterparts, and higher Sec8 expression was correlated with tumor size (p = 0.03).
|
23207790 |
2013 |
|
Alzheimer's Disease
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
|
23535033 |
2014 |
|
Alzheimer's Disease
|
0.110 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
|
23535033 |
2014 |
|
Alzheimer's Disease
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
Among the European Hispanics, a consensus region at the EXOC4 locus was significantly associated with AD even after correction for multiple testing (empirical P value 1 [EMP1], .0001; EMP2, .002; 21 AD cases vs 2 controls).
|
23978990 |
2013 |
|
Malignant neoplasm of prostate
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
FRK rs171866 remained as a significant predictor for disease progression; DAB2 rs268091 and EXOC4 rs1149558 remained as significant predictors for prostate cancer-specific mortality (PCSM); and EXOC4 rs1149558 remained as a significant predictor for all-cause mortality after ADT in multivariate models that included clinicopathologic predictors.
|
24448834 |
2014 |
|
Prostate carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
FRK rs171866 remained as a significant predictor for disease progression; DAB2 rs268091 and EXOC4 rs1149558 remained as significant predictors for prostate cancer-specific mortality (PCSM); and EXOC4 rs1149558 remained as a significant predictor for all-cause mortality after ADT in multivariate models that included clinicopathologic predictors.
|
24448834 |
2014 |
|
Malignant Peripheral Nerve Sheath Tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that Sec6 and Sec8 are therapeutic target molecules in MPNST.
|
26892009 |
2016 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence.
|
28530673 |
2017 |
|
Allergy to peanuts
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
An SNP near integrin α6 (ITGA6) reached genome-wide significance with PA (P = 1.80 × 10<sup>-8</sup>), whereas SNPs associated with Src kinase-associated phosphoprotein 1 (SKAP1), matrix metallopeptidase 12 (MMP12)/MMP13, catenin α3 (CTNNA3), rho GTPase-activating protein 24 (ARHGAP24), angiopoietin 4 (ANGPT4), chromosome 11 open reading frame (C11orf30/EMSY), and exocyst complex component 4 (EXOC4) reached a threshold suggestive of association (P ≤ 1.49 × 10<sup>-6</sup>).
|
29030101 |
2018 |
|
IgE-mediated food allergy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
When a phenotype of any food allergy was used for meta-analysis, the C11orf30 locus reached genome-wide significance (P = 7.50 × 10<sup>-11</sup>), whereas SNPs associated with ITGA6, ANGPT4, MMP12/MMP13, and EXOC4 and additional C11orf30 SNPs were suggestive (P ≤ 1.49 × 10<sup>-6</sup>).
|
29030101 |
2018 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets.
|
29186694 |
2017 |
|
QT interval feature (observable entity)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
GWAS of the electrocardiographic QT interval in Hispanics/Latinos generalizes previously identified loci and identifies population-specific signals.
|
29213071 |
2017 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.
|
29326435 |
2019 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals.
|
29520040 |
2019 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
|
29844566 |
2018 |
|
Physical Activity Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE.
|
29899525 |
2018 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.
|
29942086 |
2018 |
|
mathematical ability
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
|
30038396 |
2018 |
|
Smoking
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.
|
30643258 |
2019 |