|
Arthritis, Psoriatic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Results showed that PA significantly increased ROS generation and the levels of pro-apoptotic protein Bax, and decreased the levels of anti-apoptotic protein Bcl-2 and the mRNA expression and secretion of endothelin-1.
|
31770577 |
2020 |
|
Bronchospasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
β2-Adrenergic receptor (β2AR) agonists are clinically used to elicit rapid bronchodilation for the treatment of bronchospasms in pulmonary diseases such as asthma and COPD, both of which exhibit characteristically high levels of reactive oxygen species (ROS); likely secondary to over-expression of ROS generating enzymes and chronically heightened inflammation.
|
31697929 |
2020 |
|
Secondary malignant neoplasm of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
ROS1-rearranged tumors were also more likely to present with distant nodal metastases (ROS1, 15%; EGFR, 2%; P < .01) and sclerotic-type bone metastases (ROS1, 17%; EGFR, 6%; P < .01).
|
31708389 |
2020 |
|
Lymphangitis carcinomatosa
|
0.010 |
Biomarker
|
disease |
BEFREE |
Compared with EGFR-mutant NSCLC, ROS1-rearranged tumors were more likely to exhibit imaging features of lymphangitic carcinomatosis (ROS1, 42%; EGFR, 12%; P < .01) and less likely to have air bronchograms in the primary tumor (ROS1, 2%; EGFR, 28%; P < .01).
|
31708389 |
2020 |
|
Erectile dysfunction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Given that nitrite is described to display antioxidant effects, we hypothesized that treatment with nitrite would exert antioxidant effects attenuating both reactive oxygen species (ROS) generation in the corpora cavernosa (CC) and ED induced by hypertension.
|
31610241 |
2020 |
|
Cavitation
|
0.010 |
Biomarker
|
disease |
BEFREE |
Subsequently, GSH-triggered MnO degradation simultaneously released smaller Au NPs as numerous cavitation nucleation sites and Mn<sup>2+</sup> for chemodynamic therapy (CDT), resulting in enhanced reactive oxygen species (ROS) generation.
|
31710768 |
2020 |
|
Venous Thromboembolism
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Among 48 patients with ROS1-rearranged NSCLC enrolled in the METROS study, 20 (41.6%) of 48 had at least 1 VTE event.
|
31607443 |
2020 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, when Nrf2-knockout (Nrf2<sup>-/-</sup>) mice and cells were used to further assess the effect of the Nrf2/HO-1 pathway, we found that Nrf2 expression knockdown partially eliminated the effect of LXA4 on the reductions in inflammatory factor levels while abrogating the inhibitory effect of LXA4 on the ROS generation stimulated by AP-ALI.
|
31781326 |
2019 |
|
Anemia, Sickle Cell
|
0.010 |
Biomarker
|
disease |
BEFREE |
We hypothesized that, in SCD, TSP1-CD47 signaling promotes PH, in part, by increasing reactive oxygen species (ROS) generation.
|
30892078 |
2019 |
|
Brain Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The mitochondrial complex I enzyme is one of the main sites of ROS generation and is implicated in many BD pathophysiologies.
|
31452047 |
2019 |
|
Bronchitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggested that HY showed potential antiviral activities against IBV infection involving the inhibition of apoptosis and ROS generation in CEK cells.
|
31399732 |
2019 |
|
Endometriosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, little is known about how mitochondria regulate ROS generation and energy metabolism in endometriosis.
|
30926565 |
2019 |
|
Fatigue
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In contrast, mitochondrial respiratory function was preserved alongside lower ROS generation, which may play a compensatory role to preserve fatigue resistance in the diaphragm.<b>NEW & NOTEWORTHY</b> Diaphragm weakness is a hallmark of diseases in which oxygen delivery is compromised.
|
31487223 |
2019 |
|
Fatty Liver, Alcoholic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nicotine and cotinine enhance alcoholic fatty liver in wild type (WT) mice but not in CYP2A5 knockout (KO) mice, and reactive oxygen species (ROS) generated during the CYP2A5-mediated metabolism contributes to the enhancing effect.
|
30876690 |
2019 |
|
Lymphoma
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Crizotinib is a tyrosine kinase inhibitor (TKI) approved for the treatment of non-small cell lung cancers (NSLCL) and lymphomas expressing activating translocations or mutations of oncogenic tyrosine kinases (in particular ALK and ROS1).
|
31143519 |
2019 |
|
Mediastinal Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
ROS1-rearranged high-PD-L1-expressing lung adenocarcinoma manifesting as mediastinal tumor: A case report.
|
30655791 |
2019 |
|
Neuralgia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Pro-inflammatory microglial activation with aberrant reactive oxygen species (ROS) generation in the spinal cord plays a critical role in the development of neuropathic pain.
|
31475711 |
2019 |
|
Retinal Vein Occlusion
|
0.010 |
Biomarker
|
disease |
BEFREE |
The inflammation, angiogenesis and ROS generation was increased in RVO-ME mice, conbercept partly inhibited these effects.
|
30558792 |
2019 |
|
Retinoblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
(3) Results: Treatment with Rb1 significantly increased the cell viability and mtDNA copy number, and inhibited ROS generation.
|
31590397 |
2019 |
|
Vascular ring
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Incubation of the adipose tissue samples and vascular rings with the MAO-A inhibitor (clorgyline, 30 min) improved vascular reactivity and decreased ROS generation.
|
31051081 |
2019 |
|
Fibrillation
|
0.010 |
Biomarker
|
disease |
BEFREE |
CFDNPs surface charge, dynamic magnetic susceptibility, iron content and redox activity contribute to ROS generation, neurovascular unit (NVU), mitochondria, and endoplasmic reticulum (ER) damage, and are catalysts for protein misfolding, aggregation and fibrillation.
|
31299618 |
2019 |
|
Age related macular degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, the mitochondrial DNA damage reaction (mtDDR) is important in AMD prevention and in slowing down its progression as is ROS-targeting AMD therapy.
|
31091656 |
2019 |
|
stage, non-small cell lung cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Rearrangements of ALK/ROS1 were quantified using CTC mRNA and matched with those identified in biopsy specimens from 12 patients with late-stage non-small cell lung cancer.
|
31392269 |
2019 |
|
Immune thrombocytopenic purpura
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, ROS inhibition or blocking FcγRIIa attenuated the decrease in GPIbα surface expression, platelet activation and ROS generation (for blocking FcγRIIa) in ITP plasma-treated platelets.
|
30445311 |
2019 |
|
Alveolitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cgp91ds-TAT treatment significantly attenuated airway inflammation, including neutrophil influx, the degree of alveolitis and inflammatory cell ROS generation.
|
30884042 |
2019 |